Interleukin 1 receptor signaling regulates DUBA expression and facilitates Toll-like receptor 9-driven antiinflammatory cytokine production

The interleukin 1 receptor (IL-1R) and the Toll-like receptors (TLRs) are highly homologous innate immune receptors that provide the first line of defense against infection. We show that IL-1R type I (IL-1RI) is essential for TLR9-dependent activation of tumor necrosis factor receptor-associated fac...

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Veröffentlicht in:	The Journal of experimental medicine 2010-12, Vol.207 (13), p.2799-2807
Hauptverfasser:	González-Navajas, Jose M, Law, Jason, Nguyen, Kim Phung, Bhargava, Meha, Corr, Mary Patricia, Varki, Nissi, Eckmann, Lars, Hoffman, Hal M, Lee, Jongdae, Raz, Eyal
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brief Definitive Report Cells, Cultured Colitis - chemically induced Colitis - genetics Colitis - metabolism Cytokines - metabolism Dendritic Cells - cytology Dendritic Cells - drug effects Dendritic Cells - metabolism Dextran Sulfate Endopeptidases - genetics Endopeptidases - metabolism Female Immediate-Early Proteins - genetics Immediate-Early Proteins - metabolism Immunoblotting Interferon Type I - genetics Interferon Type I - metabolism Interferon-beta - metabolism Interleukin-10 - metabolism Male Mice Mice, Inbred C57BL Mice, Knockout Oligodeoxyribonucleotides - pharmacology Receptors, Interleukin-1 - deficiency Receptors, Interleukin-1 - genetics Receptors, Interleukin-1 - physiology Reverse Transcriptase Polymerase Chain Reaction RNA Interference Signal Transduction TNF Receptor-Associated Factor 3 - genetics TNF Receptor-Associated Factor 3 - metabolism Toll-Like Receptor 9 - genetics Toll-Like Receptor 9 - metabolism
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