Final adult height of children with inflammatory bowel disease is predicted by parental height and patient minimum height Z‐score
Background: This study was designed to elucidate the contribution of parental height to the stature of children with inflammatory bowel disease (IBD), who often exhibit growth impairment. Accordingly, we compared patients' final adult heights and target heights based on measured parental height...
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| Veröffentlicht in: | Inflammatory bowel diseases 2010-10, Vol.16 (10), p.1669-1677 |
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| creator | Lee, Jessica J. Escher, Johanna C. Shuman, Melissa J. Forbes, Peter W. Delemarre, Luçan C. Harr, Brian W. Kruijer, Marjan Moret, Marlous Allende‐Richter, Sophie Grand, Richard J. |
| description | Background:
This study was designed to elucidate the contribution of parental height to the stature of children with inflammatory bowel disease (IBD), who often exhibit growth impairment. Accordingly, we compared patients' final adult heights and target heights based on measured parental heights and examined predictors of final adult height in pediatric IBD patients.
Methods:
We prospectively analyzed the growth of 295 patients diagnosed between ages 1 and 18 (211 Crohn's disease [CD], 84 ulcerative colitis [UC]) and their family members (283 mothers, 231 fathers, 55 siblings).
Results:
Twenty‐two percent had growth impairment (height for age Z‐score |
| doi_str_mv | 10.1002/ibd.21214 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3005189</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1017977761</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4474-d9126b6d35ec327493e6da875c450f8f190d08a8a9274b2b52839c3c20e7ed3e3</originalsourceid><addsrcrecordid>eNp9kc9uFSEUhydGY2t14QsYdupiWmBggI1Jbe2fpIkb3bghDJzpYJjhCjPe3J1JX8Bn9EmkvbeNLjQsIOd8fDknv6p6SfAhwZge-c4dUkIJe1TtE960NZOMPS5vLGSNlZJ71bOcvxa0HPW02qOYUKEU369uzvxkAjJuCTMawF8PM4o9soMPLsGE1n4ekJ_6YMbRzDFtUBfXEJDzGUwG5DNaJXDezuBQt0ErU37NxbhzmcmV2uxLEY1-8uMy3re-_PrxM9uY4Hn1pDchw4vdfVB9Pvvw6eSivvp4fnlyfFVbxgSrnSK07VrXcLANFUw10DojBbeM4172RGGHpZFGlWZHO05lo2xjKQYBroHmoHq39a6WbgRny0zJBL1KfjRpo6Px-u_O5Ad9Hb_rBmNOpCqC1ztBit8WyLMefbYQgpkgLlkLzhnGkstCvvkvSTARSgjRkoK-3aI2xZwT9A8DEaxv49UlXn0Xb2Ff_bnBA3mfZwGOtsDaB9j826Qv359ulb8B0TeyJA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1017977761</pqid></control><display><type>article</type><title>Final adult height of children with inflammatory bowel disease is predicted by parental height and patient minimum height Z‐score</title><source>Wiley Online Library - AutoHoldings Journals</source><source>MEDLINE</source><source>Oxford University Press Journals All Titles (1996-Current)</source><creator>Lee, Jessica J. ; Escher, Johanna C. ; Shuman, Melissa J. ; Forbes, Peter W. ; Delemarre, Luçan C. ; Harr, Brian W. ; Kruijer, Marjan ; Moret, Marlous ; Allende‐Richter, Sophie ; Grand, Richard J.</creator><creatorcontrib>Lee, Jessica J. ; Escher, Johanna C. ; Shuman, Melissa J. ; Forbes, Peter W. ; Delemarre, Luçan C. ; Harr, Brian W. ; Kruijer, Marjan ; Moret, Marlous ; Allende‐Richter, Sophie ; Grand, Richard J.</creatorcontrib><description>Background:
This study was designed to elucidate the contribution of parental height to the stature of children with inflammatory bowel disease (IBD), who often exhibit growth impairment. Accordingly, we compared patients' final adult heights and target heights based on measured parental heights and examined predictors of final adult height in pediatric IBD patients.
Methods:
We prospectively analyzed the growth of 295 patients diagnosed between ages 1 and 18 (211 Crohn's disease [CD], 84 ulcerative colitis [UC]) and their family members (283 mothers, 231 fathers, 55 siblings).
Results:
Twenty‐two percent had growth impairment (height for age Z‐score <−1.64, equivalent to <5th percentile on growth curve) in more than 1 measurement since diagnosis; most growth‐impaired patients had CD (88% CD versus 12% UC). Parents of the growth‐impaired group had lower mean height Z‐scores compared to parents of nongrowth‐impaired patients (−0.67 versus 0.02 for mothers [P < 0.001]; −0.31 versus 0.22 for fathers [P = 0.002]). For 108 patients who reached adult heights and had available parental heights, the growth‐impaired group continued to demonstrate lower adult height Z‐scores (−1.38 versus 0.07; P < 0.001). Adult heights were within 1 SD of target heights even for the growth‐impaired group. Only 11.3% remained persistently growth‐impaired in adulthood. Multivariate regression analysis demonstrated lower parental height and minimum patient height Z‐score as significant predictors of lower final adult height in IBD.
Conclusions:
Parental height is a powerful determinant of linear growth even in the presence of chronic inflammation, and should be an integral part of the evaluation of growth in IBD children. (Inflamm Bowel Dis 2010)</description><identifier>ISSN: 1078-0998</identifier><identifier>ISSN: 1536-4844</identifier><identifier>EISSN: 1536-4844</identifier><identifier>DOI: 10.1002/ibd.21214</identifier><identifier>PMID: 20127995</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adolescent ; Adult ; Age ; Body height ; Body Height - physiology ; Bone growth ; Child ; Child, Preschool ; Children ; Cohort Studies ; Colitis, Ulcerative - physiopathology ; Crohn Disease - physiopathology ; Crohn's disease ; Female ; Growth Disorders - physiopathology ; growth retardation ; Humans ; Infant ; Inflammatory bowel diseases ; Intestine ; Male ; Parents ; pediatric ; Pediatrics ; Prognosis ; Prospective Studies ; Regression analysis ; Siblings ; Statistics, Nonparametric ; Ulcerative colitis ; Young Adult</subject><ispartof>Inflammatory bowel diseases, 2010-10, Vol.16 (10), p.1669-1677</ispartof><rights>Copyright © 2010 Crohn's & Colitis Foundation of America, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4474-d9126b6d35ec327493e6da875c450f8f190d08a8a9274b2b52839c3c20e7ed3e3</citedby><cites>FETCH-LOGICAL-c4474-d9126b6d35ec327493e6da875c450f8f190d08a8a9274b2b52839c3c20e7ed3e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fibd.21214$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fibd.21214$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,315,782,786,887,1419,27931,27932,45581,45582</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20127995$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, Jessica J.</creatorcontrib><creatorcontrib>Escher, Johanna C.</creatorcontrib><creatorcontrib>Shuman, Melissa J.</creatorcontrib><creatorcontrib>Forbes, Peter W.</creatorcontrib><creatorcontrib>Delemarre, Luçan C.</creatorcontrib><creatorcontrib>Harr, Brian W.</creatorcontrib><creatorcontrib>Kruijer, Marjan</creatorcontrib><creatorcontrib>Moret, Marlous</creatorcontrib><creatorcontrib>Allende‐Richter, Sophie</creatorcontrib><creatorcontrib>Grand, Richard J.</creatorcontrib><title>Final adult height of children with inflammatory bowel disease is predicted by parental height and patient minimum height Z‐score</title><title>Inflammatory bowel diseases</title><addtitle>Inflamm Bowel Dis</addtitle><description>Background:
This study was designed to elucidate the contribution of parental height to the stature of children with inflammatory bowel disease (IBD), who often exhibit growth impairment. Accordingly, we compared patients' final adult heights and target heights based on measured parental heights and examined predictors of final adult height in pediatric IBD patients.
Methods:
We prospectively analyzed the growth of 295 patients diagnosed between ages 1 and 18 (211 Crohn's disease [CD], 84 ulcerative colitis [UC]) and their family members (283 mothers, 231 fathers, 55 siblings).
Results:
Twenty‐two percent had growth impairment (height for age Z‐score <−1.64, equivalent to <5th percentile on growth curve) in more than 1 measurement since diagnosis; most growth‐impaired patients had CD (88% CD versus 12% UC). Parents of the growth‐impaired group had lower mean height Z‐scores compared to parents of nongrowth‐impaired patients (−0.67 versus 0.02 for mothers [P < 0.001]; −0.31 versus 0.22 for fathers [P = 0.002]). For 108 patients who reached adult heights and had available parental heights, the growth‐impaired group continued to demonstrate lower adult height Z‐scores (−1.38 versus 0.07; P < 0.001). Adult heights were within 1 SD of target heights even for the growth‐impaired group. Only 11.3% remained persistently growth‐impaired in adulthood. Multivariate regression analysis demonstrated lower parental height and minimum patient height Z‐score as significant predictors of lower final adult height in IBD.
Conclusions:
Parental height is a powerful determinant of linear growth even in the presence of chronic inflammation, and should be an integral part of the evaluation of growth in IBD children. (Inflamm Bowel Dis 2010)</description><subject>Adolescent</subject><subject>Adult</subject><subject>Age</subject><subject>Body height</subject><subject>Body Height - physiology</subject><subject>Bone growth</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>Cohort Studies</subject><subject>Colitis, Ulcerative - physiopathology</subject><subject>Crohn Disease - physiopathology</subject><subject>Crohn's disease</subject><subject>Female</subject><subject>Growth Disorders - physiopathology</subject><subject>growth retardation</subject><subject>Humans</subject><subject>Infant</subject><subject>Inflammatory bowel diseases</subject><subject>Intestine</subject><subject>Male</subject><subject>Parents</subject><subject>pediatric</subject><subject>Pediatrics</subject><subject>Prognosis</subject><subject>Prospective Studies</subject><subject>Regression analysis</subject><subject>Siblings</subject><subject>Statistics, Nonparametric</subject><subject>Ulcerative colitis</subject><subject>Young Adult</subject><issn>1078-0998</issn><issn>1536-4844</issn><issn>1536-4844</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc9uFSEUhydGY2t14QsYdupiWmBggI1Jbe2fpIkb3bghDJzpYJjhCjPe3J1JX8Bn9EmkvbeNLjQsIOd8fDknv6p6SfAhwZge-c4dUkIJe1TtE960NZOMPS5vLGSNlZJ71bOcvxa0HPW02qOYUKEU369uzvxkAjJuCTMawF8PM4o9soMPLsGE1n4ekJ_6YMbRzDFtUBfXEJDzGUwG5DNaJXDezuBQt0ErU37NxbhzmcmV2uxLEY1-8uMy3re-_PrxM9uY4Hn1pDchw4vdfVB9Pvvw6eSivvp4fnlyfFVbxgSrnSK07VrXcLANFUw10DojBbeM4172RGGHpZFGlWZHO05lo2xjKQYBroHmoHq39a6WbgRny0zJBL1KfjRpo6Px-u_O5Ad9Hb_rBmNOpCqC1ztBit8WyLMefbYQgpkgLlkLzhnGkstCvvkvSTARSgjRkoK-3aI2xZwT9A8DEaxv49UlXn0Xb2Ff_bnBA3mfZwGOtsDaB9j826Qv359ulb8B0TeyJA</recordid><startdate>201010</startdate><enddate>201010</enddate><creator>Lee, Jessica J.</creator><creator>Escher, Johanna C.</creator><creator>Shuman, Melissa J.</creator><creator>Forbes, Peter W.</creator><creator>Delemarre, Luçan C.</creator><creator>Harr, Brian W.</creator><creator>Kruijer, Marjan</creator><creator>Moret, Marlous</creator><creator>Allende‐Richter, Sophie</creator><creator>Grand, Richard J.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201010</creationdate><title>Final adult height of children with inflammatory bowel disease is predicted by parental height and patient minimum height Z‐score</title><author>Lee, Jessica J. ; Escher, Johanna C. ; Shuman, Melissa J. ; Forbes, Peter W. ; Delemarre, Luçan C. ; Harr, Brian W. ; Kruijer, Marjan ; Moret, Marlous ; Allende‐Richter, Sophie ; Grand, Richard J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4474-d9126b6d35ec327493e6da875c450f8f190d08a8a9274b2b52839c3c20e7ed3e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Age</topic><topic>Body height</topic><topic>Body Height - physiology</topic><topic>Bone growth</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Children</topic><topic>Cohort Studies</topic><topic>Colitis, Ulcerative - physiopathology</topic><topic>Crohn Disease - physiopathology</topic><topic>Crohn's disease</topic><topic>Female</topic><topic>Growth Disorders - physiopathology</topic><topic>growth retardation</topic><topic>Humans</topic><topic>Infant</topic><topic>Inflammatory bowel diseases</topic><topic>Intestine</topic><topic>Male</topic><topic>Parents</topic><topic>pediatric</topic><topic>Pediatrics</topic><topic>Prognosis</topic><topic>Prospective Studies</topic><topic>Regression analysis</topic><topic>Siblings</topic><topic>Statistics, Nonparametric</topic><topic>Ulcerative colitis</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Jessica J.</creatorcontrib><creatorcontrib>Escher, Johanna C.</creatorcontrib><creatorcontrib>Shuman, Melissa J.</creatorcontrib><creatorcontrib>Forbes, Peter W.</creatorcontrib><creatorcontrib>Delemarre, Luçan C.</creatorcontrib><creatorcontrib>Harr, Brian W.</creatorcontrib><creatorcontrib>Kruijer, Marjan</creatorcontrib><creatorcontrib>Moret, Marlous</creatorcontrib><creatorcontrib>Allende‐Richter, Sophie</creatorcontrib><creatorcontrib>Grand, Richard J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Inflammatory bowel diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Jessica J.</au><au>Escher, Johanna C.</au><au>Shuman, Melissa J.</au><au>Forbes, Peter W.</au><au>Delemarre, Luçan C.</au><au>Harr, Brian W.</au><au>Kruijer, Marjan</au><au>Moret, Marlous</au><au>Allende‐Richter, Sophie</au><au>Grand, Richard J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Final adult height of children with inflammatory bowel disease is predicted by parental height and patient minimum height Z‐score</atitle><jtitle>Inflammatory bowel diseases</jtitle><addtitle>Inflamm Bowel Dis</addtitle><date>2010-10</date><risdate>2010</risdate><volume>16</volume><issue>10</issue><spage>1669</spage><epage>1677</epage><pages>1669-1677</pages><issn>1078-0998</issn><issn>1536-4844</issn><eissn>1536-4844</eissn><abstract>Background:
This study was designed to elucidate the contribution of parental height to the stature of children with inflammatory bowel disease (IBD), who often exhibit growth impairment. Accordingly, we compared patients' final adult heights and target heights based on measured parental heights and examined predictors of final adult height in pediatric IBD patients.
Methods:
We prospectively analyzed the growth of 295 patients diagnosed between ages 1 and 18 (211 Crohn's disease [CD], 84 ulcerative colitis [UC]) and their family members (283 mothers, 231 fathers, 55 siblings).
Results:
Twenty‐two percent had growth impairment (height for age Z‐score <−1.64, equivalent to <5th percentile on growth curve) in more than 1 measurement since diagnosis; most growth‐impaired patients had CD (88% CD versus 12% UC). Parents of the growth‐impaired group had lower mean height Z‐scores compared to parents of nongrowth‐impaired patients (−0.67 versus 0.02 for mothers [P < 0.001]; −0.31 versus 0.22 for fathers [P = 0.002]). For 108 patients who reached adult heights and had available parental heights, the growth‐impaired group continued to demonstrate lower adult height Z‐scores (−1.38 versus 0.07; P < 0.001). Adult heights were within 1 SD of target heights even for the growth‐impaired group. Only 11.3% remained persistently growth‐impaired in adulthood. Multivariate regression analysis demonstrated lower parental height and minimum patient height Z‐score as significant predictors of lower final adult height in IBD.
Conclusions:
Parental height is a powerful determinant of linear growth even in the presence of chronic inflammation, and should be an integral part of the evaluation of growth in IBD children. (Inflamm Bowel Dis 2010)</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>20127995</pmid><doi>10.1002/ibd.21214</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1078-0998 |
| ispartof | Inflammatory bowel diseases, 2010-10, Vol.16 (10), p.1669-1677 |
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| language | eng |
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| source | Wiley Online Library - AutoHoldings Journals; MEDLINE; Oxford University Press Journals All Titles (1996-Current) |
| subjects | Adolescent Adult Age Body height Body Height - physiology Bone growth Child Child, Preschool Children Cohort Studies Colitis, Ulcerative - physiopathology Crohn Disease - physiopathology Crohn's disease Female Growth Disorders - physiopathology growth retardation Humans Infant Inflammatory bowel diseases Intestine Male Parents pediatric Pediatrics Prognosis Prospective Studies Regression analysis Siblings Statistics, Nonparametric Ulcerative colitis Young Adult |
| title | Final adult height of children with inflammatory bowel disease is predicted by parental height and patient minimum height Z‐score |
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