Manipulating Protein Acetylation in Breast Cancer : A Promising Approach in Combination with Hormonal Therapies?

Estrogens play an essential role in the normal physiology of the breast as well as in mammary tumorigenesis. Their effects are mediated by two nuclear estrogen receptors, ERα and β, which regulate transcription of specific genes by interacting with multiprotein complexes, including histone deacetyla...

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Veröffentlicht in:	BioMed research international 2011-01, Vol.2011 (2011), p.1-15
Hauptverfasser:	Linares, Aurélien, Dalenc, Florence, Balaguer, Patrick, Boulle, Nathalie, Cavailles, Vincent
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Antineoplastic Agents, Hormonal - pharmacology Antineoplastic Agents, Hormonal - therapeutic use Apoptosis Biochemistry, Molecular Biology Biomarkers Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - metabolism Cancer Cancer therapies Care and treatment Development and progression DNA repair Drug Resistance, Neoplasm Epigenetics Female Genetic aspects Health aspects Histone Deacetylase Inhibitors - pharmacology Histone Deacetylase Inhibitors - therapeutic use Hormone therapy Humans Kinases Life Sciences Neoplasm Proteins - metabolism Protein folding Review Signal Transduction - drug effects Tumors
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