Manipulating Protein Acetylation in Breast Cancer : A Promising Approach in Combination with Hormonal Therapies?
Estrogens play an essential role in the normal physiology of the breast as well as in mammary tumorigenesis. Their effects are mediated by two nuclear estrogen receptors, ERα and β, which regulate transcription of specific genes by interacting with multiprotein complexes, including histone deacetyla...
Gespeichert in:
| Veröffentlicht in: | BioMed research international 2011-01, Vol.2011 (2011), p.1-15 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 15 |
|---|---|
| container_issue | 2011 |
| container_start_page | 1 |
| container_title | BioMed research international |
| container_volume | 2011 |
| creator | Linares, Aurélien Dalenc, Florence Balaguer, Patrick Boulle, Nathalie Cavailles, Vincent |
| description | Estrogens play an essential role in the normal physiology of the breast as well as in mammary tumorigenesis. Their effects are mediated by two nuclear estrogen receptors, ERα and β, which regulate transcription of specific genes by interacting with multiprotein complexes, including histone deacetylases (HDACs). During the past few years, HDACs have raised great interest as therapeutic targets in the field of cancer therapy. In breast cancer, several experimental arguments suggest that HDACs are involved at multiple levels in mammary tumorigenesis: their expression is deregulated in breast tumors; they interfere with ER signaling in intricate ways, restoring hormone sensitivity in models of estrogen resistance, and they clinically represent new potential targets for HDACs inhibitors (HDIs) in combination with hormonal therapies. In this paper, we will describe these different aspects and underline the clinical interest of HDIs in the context of breast cancer resistance to hormone therapies (HTs). |
| doi_str_mv | 10.1155/2011/856985 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3004450</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A266630001</galeid><sourcerecordid>A266630001</sourcerecordid><originalsourceid>FETCH-LOGICAL-c606t-647569bcff4e5c2f39690561b8575a0445e3979c2dabaf5a8cbd62c3f9414dfa3</originalsourceid><addsrcrecordid>eNqFksFv0zAUxiMEYmNw4gyKxgFp0M1OYjvmAMoqoEhFcBhny3GeW0-JHexk0_57HKVUbKpEcohj_77v2Z9fkrzE6BxjQi4yhPFFSSgvyaPkGGOMFiwj-PF-XORHybMQrhHCrKT8aXKUYVyWmOXHSf9dWtOPrRyM3aQ_vRvA2LRSMNxNc86m8ffSgwxDupRWgU8_pNUEdiZMkqrvvZNqO3FL19XGzrJbM2zTlfOds7JNr7bgZW8gfHqePNGyDfBi9z1Jfn35fLVcLdY_vn5bVuuFoogOC1qweKJaaV0AUZnOOeWIUFyXhBGJioJAzhlXWSNrqYksVd3QTOWaF7hotMxPko-zbz_WHTQK7OBlK3pvOunvhJNG3F-xZis27kbkaHJH0eD9bLB9IFtVa2FsAN8JhMj05Dc44m939bz7PUIYRAxIQdtKC24Mosww4QxxFsnTB-S1G31MKULxzKzkvIjQmxnayBZiOe3iJtVkKaqMUhp3iaaiiwPUBmxMu3UWtInT9_jzA3x8G-iMOih4NwuUdyF40PskMBJT94mp-8TcfZF-_W_me_Zvu0XgbJepsY28Nf9xezXDEBHQcg_Hy2GM5X8ApCDpdQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>856978994</pqid></control><display><type>article</type><title>Manipulating Protein Acetylation in Breast Cancer : A Promising Approach in Combination with Hormonal Therapies?</title><source>PubMed Central 开放获取</source><source>MEDLINE</source><source>Wiley Online Library Open Access</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>Linares, Aurélien ; Dalenc, Florence ; Balaguer, Patrick ; Boulle, Nathalie ; Cavailles, Vincent</creator><contributor>Yoshida, Minoru</contributor><creatorcontrib>Linares, Aurélien ; Dalenc, Florence ; Balaguer, Patrick ; Boulle, Nathalie ; Cavailles, Vincent ; Yoshida, Minoru</creatorcontrib><description>Estrogens play an essential role in the normal physiology of the breast as well as in mammary tumorigenesis. Their effects are mediated by two nuclear estrogen receptors, ERα and β, which regulate transcription of specific genes by interacting with multiprotein complexes, including histone deacetylases (HDACs). During the past few years, HDACs have raised great interest as therapeutic targets in the field of cancer therapy. In breast cancer, several experimental arguments suggest that HDACs are involved at multiple levels in mammary tumorigenesis: their expression is deregulated in breast tumors; they interfere with ER signaling in intricate ways, restoring hormone sensitivity in models of estrogen resistance, and they clinically represent new potential targets for HDACs inhibitors (HDIs) in combination with hormonal therapies. In this paper, we will describe these different aspects and underline the clinical interest of HDIs in the context of breast cancer resistance to hormone therapies (HTs).</description><identifier>ISSN: 1110-7243</identifier><identifier>ISSN: 2314-6133</identifier><identifier>EISSN: 1110-7251</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2011/856985</identifier><identifier>PMID: 21188173</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Puplishing Corporation</publisher><subject>Acetylation ; Antineoplastic Agents, Hormonal - pharmacology ; Antineoplastic Agents, Hormonal - therapeutic use ; Apoptosis ; Biochemistry, Molecular Biology ; Biomarkers ; Breast cancer ; Breast Neoplasms - drug therapy ; Breast Neoplasms - metabolism ; Cancer ; Cancer therapies ; Care and treatment ; Development and progression ; DNA repair ; Drug Resistance, Neoplasm ; Epigenetics ; Female ; Genetic aspects ; Health aspects ; Histone Deacetylase Inhibitors - pharmacology ; Histone Deacetylase Inhibitors - therapeutic use ; Hormone therapy ; Humans ; Kinases ; Life Sciences ; Neoplasm Proteins - metabolism ; Protein folding ; Review ; Signal Transduction - drug effects ; Tumors</subject><ispartof>BioMed research international, 2011-01, Vol.2011 (2011), p.1-15</ispartof><rights>Copyright © 2011 Aurélien Linares et al.</rights><rights>COPYRIGHT 2011 John Wiley & Sons, Inc.</rights><rights>Copyright © 2011 Aurélien Linares et al. Aurélien Linares et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><rights>Copyright © 2011 Aurélien Linares et al. 2011 Copyright © 2011 Aurélien Linares et al.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c606t-647569bcff4e5c2f39690561b8575a0445e3979c2dabaf5a8cbd62c3f9414dfa3</citedby><cites>FETCH-LOGICAL-c606t-647569bcff4e5c2f39690561b8575a0445e3979c2dabaf5a8cbd62c3f9414dfa3</cites><orcidid>0000-0002-7160-3074 ; 0000-0002-0990-4722 ; 0000-0002-3524-3622</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3004450/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3004450/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21188173$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://inserm.hal.science/inserm-00555553$$DView record in HAL$$Hfree_for_read</backlink></links><search><contributor>Yoshida, Minoru</contributor><creatorcontrib>Linares, Aurélien</creatorcontrib><creatorcontrib>Dalenc, Florence</creatorcontrib><creatorcontrib>Balaguer, Patrick</creatorcontrib><creatorcontrib>Boulle, Nathalie</creatorcontrib><creatorcontrib>Cavailles, Vincent</creatorcontrib><title>Manipulating Protein Acetylation in Breast Cancer : A Promising Approach in Combination with Hormonal Therapies?</title><title>BioMed research international</title><addtitle>J Biomed Biotechnol</addtitle><description>Estrogens play an essential role in the normal physiology of the breast as well as in mammary tumorigenesis. Their effects are mediated by two nuclear estrogen receptors, ERα and β, which regulate transcription of specific genes by interacting with multiprotein complexes, including histone deacetylases (HDACs). During the past few years, HDACs have raised great interest as therapeutic targets in the field of cancer therapy. In breast cancer, several experimental arguments suggest that HDACs are involved at multiple levels in mammary tumorigenesis: their expression is deregulated in breast tumors; they interfere with ER signaling in intricate ways, restoring hormone sensitivity in models of estrogen resistance, and they clinically represent new potential targets for HDACs inhibitors (HDIs) in combination with hormonal therapies. In this paper, we will describe these different aspects and underline the clinical interest of HDIs in the context of breast cancer resistance to hormone therapies (HTs).</description><subject>Acetylation</subject><subject>Antineoplastic Agents, Hormonal - pharmacology</subject><subject>Antineoplastic Agents, Hormonal - therapeutic use</subject><subject>Apoptosis</subject><subject>Biochemistry, Molecular Biology</subject><subject>Biomarkers</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - drug therapy</subject><subject>Breast Neoplasms - metabolism</subject><subject>Cancer</subject><subject>Cancer therapies</subject><subject>Care and treatment</subject><subject>Development and progression</subject><subject>DNA repair</subject><subject>Drug Resistance, Neoplasm</subject><subject>Epigenetics</subject><subject>Female</subject><subject>Genetic aspects</subject><subject>Health aspects</subject><subject>Histone Deacetylase Inhibitors - pharmacology</subject><subject>Histone Deacetylase Inhibitors - therapeutic use</subject><subject>Hormone therapy</subject><subject>Humans</subject><subject>Kinases</subject><subject>Life Sciences</subject><subject>Neoplasm Proteins - metabolism</subject><subject>Protein folding</subject><subject>Review</subject><subject>Signal Transduction - drug effects</subject><subject>Tumors</subject><issn>1110-7243</issn><issn>2314-6133</issn><issn>1110-7251</issn><issn>2314-6141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFksFv0zAUxiMEYmNw4gyKxgFp0M1OYjvmAMoqoEhFcBhny3GeW0-JHexk0_57HKVUbKpEcohj_77v2Z9fkrzE6BxjQi4yhPFFSSgvyaPkGGOMFiwj-PF-XORHybMQrhHCrKT8aXKUYVyWmOXHSf9dWtOPrRyM3aQ_vRvA2LRSMNxNc86m8ffSgwxDupRWgU8_pNUEdiZMkqrvvZNqO3FL19XGzrJbM2zTlfOds7JNr7bgZW8gfHqePNGyDfBi9z1Jfn35fLVcLdY_vn5bVuuFoogOC1qweKJaaV0AUZnOOeWIUFyXhBGJioJAzhlXWSNrqYksVd3QTOWaF7hotMxPko-zbz_WHTQK7OBlK3pvOunvhJNG3F-xZis27kbkaHJH0eD9bLB9IFtVa2FsAN8JhMj05Dc44m939bz7PUIYRAxIQdtKC24Mosww4QxxFsnTB-S1G31MKULxzKzkvIjQmxnayBZiOe3iJtVkKaqMUhp3iaaiiwPUBmxMu3UWtInT9_jzA3x8G-iMOih4NwuUdyF40PskMBJT94mp-8TcfZF-_W_me_Zvu0XgbJepsY28Nf9xezXDEBHQcg_Hy2GM5X8ApCDpdQ</recordid><startdate>20110101</startdate><enddate>20110101</enddate><creator>Linares, Aurélien</creator><creator>Dalenc, Florence</creator><creator>Balaguer, Patrick</creator><creator>Boulle, Nathalie</creator><creator>Cavailles, Vincent</creator><general>Hindawi Puplishing Corporation</general><general>Hindawi Publishing Corporation</general><general>John Wiley & Sons, Inc</general><general>Hindawi Limited</general><scope>ADJCN</scope><scope>AFFIF</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QO</scope><scope>7T7</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>CWDGH</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>1XC</scope><scope>VOOES</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-7160-3074</orcidid><orcidid>https://orcid.org/0000-0002-0990-4722</orcidid><orcidid>https://orcid.org/0000-0002-3524-3622</orcidid></search><sort><creationdate>20110101</creationdate><title>Manipulating Protein Acetylation in Breast Cancer : A Promising Approach in Combination with Hormonal Therapies?</title><author>Linares, Aurélien ; Dalenc, Florence ; Balaguer, Patrick ; Boulle, Nathalie ; Cavailles, Vincent</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c606t-647569bcff4e5c2f39690561b8575a0445e3979c2dabaf5a8cbd62c3f9414dfa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Acetylation</topic><topic>Antineoplastic Agents, Hormonal - pharmacology</topic><topic>Antineoplastic Agents, Hormonal - therapeutic use</topic><topic>Apoptosis</topic><topic>Biochemistry, Molecular Biology</topic><topic>Biomarkers</topic><topic>Breast cancer</topic><topic>Breast Neoplasms - drug therapy</topic><topic>Breast Neoplasms - metabolism</topic><topic>Cancer</topic><topic>Cancer therapies</topic><topic>Care and treatment</topic><topic>Development and progression</topic><topic>DNA repair</topic><topic>Drug Resistance, Neoplasm</topic><topic>Epigenetics</topic><topic>Female</topic><topic>Genetic aspects</topic><topic>Health aspects</topic><topic>Histone Deacetylase Inhibitors - pharmacology</topic><topic>Histone Deacetylase Inhibitors - therapeutic use</topic><topic>Hormone therapy</topic><topic>Humans</topic><topic>Kinases</topic><topic>Life Sciences</topic><topic>Neoplasm Proteins - metabolism</topic><topic>Protein folding</topic><topic>Review</topic><topic>Signal Transduction - drug effects</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Linares, Aurélien</creatorcontrib><creatorcontrib>Dalenc, Florence</creatorcontrib><creatorcontrib>Balaguer, Patrick</creatorcontrib><creatorcontrib>Boulle, Nathalie</creatorcontrib><creatorcontrib>Cavailles, Vincent</creatorcontrib><collection>الدوريات العلمية والإحصائية - e-Marefa Academic and Statistical Periodicals</collection><collection>قاعدة دراسات المرأة - e-Marefa Women Studies</collection><collection>معرفة - المحتوى العربي الأكاديمي المتكامل - e-Marefa Academic Complete</collection><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>ProQuest - Health & Medical Complete保健、医学与药学数据库</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Database (1962 - current)</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>Middle East & Africa Database</collection><collection>ProQuest Central</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biological Sciences</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>ProQuest advanced technologies & aerospace journals</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>Hyper Article en Ligne (HAL) (Open Access)</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BioMed research international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Linares, Aurélien</au><au>Dalenc, Florence</au><au>Balaguer, Patrick</au><au>Boulle, Nathalie</au><au>Cavailles, Vincent</au><au>Yoshida, Minoru</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Manipulating Protein Acetylation in Breast Cancer : A Promising Approach in Combination with Hormonal Therapies?</atitle><jtitle>BioMed research international</jtitle><addtitle>J Biomed Biotechnol</addtitle><date>2011-01-01</date><risdate>2011</risdate><volume>2011</volume><issue>2011</issue><spage>1</spage><epage>15</epage><pages>1-15</pages><issn>1110-7243</issn><issn>2314-6133</issn><eissn>1110-7251</eissn><eissn>2314-6141</eissn><abstract>Estrogens play an essential role in the normal physiology of the breast as well as in mammary tumorigenesis. Their effects are mediated by two nuclear estrogen receptors, ERα and β, which regulate transcription of specific genes by interacting with multiprotein complexes, including histone deacetylases (HDACs). During the past few years, HDACs have raised great interest as therapeutic targets in the field of cancer therapy. In breast cancer, several experimental arguments suggest that HDACs are involved at multiple levels in mammary tumorigenesis: their expression is deregulated in breast tumors; they interfere with ER signaling in intricate ways, restoring hormone sensitivity in models of estrogen resistance, and they clinically represent new potential targets for HDACs inhibitors (HDIs) in combination with hormonal therapies. In this paper, we will describe these different aspects and underline the clinical interest of HDIs in the context of breast cancer resistance to hormone therapies (HTs).</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Puplishing Corporation</pub><pmid>21188173</pmid><doi>10.1155/2011/856985</doi><tpages>15</tpages><orcidid>https://orcid.org/0000-0002-7160-3074</orcidid><orcidid>https://orcid.org/0000-0002-0990-4722</orcidid><orcidid>https://orcid.org/0000-0002-3524-3622</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1110-7243 |
| ispartof | BioMed research international, 2011-01, Vol.2011 (2011), p.1-15 |
| issn | 1110-7243 2314-6133 1110-7251 2314-6141 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3004450 |
| source | PubMed Central 开放获取; MEDLINE; Wiley Online Library Open Access; PubMed Central; Alma/SFX Local Collection |
| subjects | Acetylation Antineoplastic Agents, Hormonal - pharmacology Antineoplastic Agents, Hormonal - therapeutic use Apoptosis Biochemistry, Molecular Biology Biomarkers Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - metabolism Cancer Cancer therapies Care and treatment Development and progression DNA repair Drug Resistance, Neoplasm Epigenetics Female Genetic aspects Health aspects Histone Deacetylase Inhibitors - pharmacology Histone Deacetylase Inhibitors - therapeutic use Hormone therapy Humans Kinases Life Sciences Neoplasm Proteins - metabolism Protein folding Review Signal Transduction - drug effects Tumors |
| title | Manipulating Protein Acetylation in Breast Cancer : A Promising Approach in Combination with Hormonal Therapies? |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-01T08%3A52%3A01IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Manipulating%20Protein%20Acetylation%20in%20Breast%20Cancer%20:%20A%20Promising%20Approach%20in%20Combination%20with%20Hormonal%20Therapies?&rft.jtitle=BioMed%20research%20international&rft.au=Linares,%20Aur%C3%A9lien&rft.date=2011-01-01&rft.volume=2011&rft.issue=2011&rft.spage=1&rft.epage=15&rft.pages=1-15&rft.issn=1110-7243&rft.eissn=1110-7251&rft_id=info:doi/10.1155/2011/856985&rft_dat=%3Cgale_pubme%3EA266630001%3C/gale_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=856978994&rft_id=info:pmid/21188173&rft_galeid=A266630001&rfr_iscdi=true |