Coronavirus Immunoreactivity in Individuals With a Recent Onset of Psychotic Symptoms
Prenatal influenza exposure increases the risk for schizophrenia and brings to question how other respiratory viruses may contribute to neuropsychiatric disease etiopathology. Human coronaviruses cause respiratory infections that range in seriousness from common colds to severe acute respiratory syn...
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Veröffentlicht in: | Schizophrenia bulletin 2011-01, Vol.37 (1), p.101-107 |
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description | Prenatal influenza exposure increases the risk for schizophrenia and brings to question how other respiratory viruses may contribute to neuropsychiatric disease etiopathology. Human coronaviruses cause respiratory infections that range in seriousness from common colds to severe acute respiratory syndrome. Like influenza, coronaviruses can be neurotropic. To test for associations between coronaviruses and serious mental disorders, we utilized a recently developed assay and measured immunoglobulin G (IgG) response against 4 human coronavirus strains (229E, HKU1, NL63, and OC43) in 106 patients with a recent onset of psychotic symptoms and 196 nonpsychiatric controls. We expressed results quantitatively as antibody levels and qualitatively as seroprevalence relative to a defined seropositivity cutoff value. Patient IgG levels were higher than controls for HKU1, NL63, and OC43, with HKU1 and NL63 both showing highly significant patient-to-control differences (HKU1, P ≤ .002; NL63, P ≤ .00001). All 4 coronaviruses were more seroprevalent in patients vs controls, with greatest intergroup differences observed for HKU1 (93% vs 77%, P ≤ .0001). HKU1 and NL63 associations with the patient group were further supported by multivariate analyses that controlled for age, gender, race, socioeconomic status, and smoking status (HKU1, odds ratio [OR] = 1.32, 95% confidence interval [CI] = 1.03-1.67, P ≤ .027; NL63, OR = 2.42, 95% CI = 1.25-4.66, P ≤ .008). Among patients, NL63 was associated with schizophrenia-spectrum (OR = 3.10, 95% CI = 1.27-7.58, P ≤ .013) but not mood disorders. HKU1 and NL63 coronavirus exposures may represent comorbid risk factors in neuropsychiatric disease. Future studies should explore links between the timing of coronavirus infections and subsequent development of schizophrenia and other disorders with psychotic symptoms. |
doi_str_mv | 10.1093/schbul/sbp052 |
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Human coronaviruses cause respiratory infections that range in seriousness from common colds to severe acute respiratory syndrome. Like influenza, coronaviruses can be neurotropic. To test for associations between coronaviruses and serious mental disorders, we utilized a recently developed assay and measured immunoglobulin G (IgG) response against 4 human coronavirus strains (229E, HKU1, NL63, and OC43) in 106 patients with a recent onset of psychotic symptoms and 196 nonpsychiatric controls. We expressed results quantitatively as antibody levels and qualitatively as seroprevalence relative to a defined seropositivity cutoff value. Patient IgG levels were higher than controls for HKU1, NL63, and OC43, with HKU1 and NL63 both showing highly significant patient-to-control differences (HKU1, P ≤ .002; NL63, P ≤ .00001). All 4 coronaviruses were more seroprevalent in patients vs controls, with greatest intergroup differences observed for HKU1 (93% vs 77%, P ≤ .0001). HKU1 and NL63 associations with the patient group were further supported by multivariate analyses that controlled for age, gender, race, socioeconomic status, and smoking status (HKU1, odds ratio [OR] = 1.32, 95% confidence interval [CI] = 1.03-1.67, P ≤ .027; NL63, OR = 2.42, 95% CI = 1.25-4.66, P ≤ .008). Among patients, NL63 was associated with schizophrenia-spectrum (OR = 3.10, 95% CI = 1.27-7.58, P ≤ .013) but not mood disorders. HKU1 and NL63 coronavirus exposures may represent comorbid risk factors in neuropsychiatric disease. Future studies should explore links between the timing of coronavirus infections and subsequent development of schizophrenia and other disorders with psychotic symptoms.</description><identifier>ISSN: 0586-7614</identifier><identifier>EISSN: 1745-1701</identifier><identifier>DOI: 10.1093/schbul/sbp052</identifier><identifier>PMID: 19491313</identifier><identifier>CODEN: SCZBB3</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Adolescent ; Adult ; Adult and adolescent clinical studies ; Age ; Aged ; Biological and medical sciences ; Bipolar disorders ; Common cold ; Comorbidity ; Coronavirus - immunology ; Coronavirus Infections - complications ; Coronavirus Infections - diagnosis ; Coronavirus Infections - immunology ; Female ; Humans ; Immunoglobulin G ; Immunoglobulin G - blood ; Immunoreactivity ; Infection ; Influenza ; Male ; Medical sciences ; Mental disorders ; Middle Aged ; Mood ; Mood disorders ; Multivariate analysis ; Prenatal experience ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Psychoses ; Psychotic Disorders - immunology ; Psychotic Disorders - virology ; Races ; Regular ; Risk factors ; SARS coronavirus ; Schizophrenia ; Severe acute respiratory syndrome ; Smoking ; Socio-economic aspects ; Young Adult</subject><ispartof>Schizophrenia bulletin, 2011-01, Vol.37 (1), p.101-107</ispartof><rights>2015 INIST-CNRS</rights><rights>The Author 2009. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved. For permissions, please email: journals.permissions@oxfordjournals.org. 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c477t-b0001d7b5479a8bcf29e5f5ff705670e153a142b5d4af812d7c5a4c36c9e4d743</citedby><cites>FETCH-LOGICAL-c477t-b0001d7b5479a8bcf29e5f5ff705670e153a142b5d4af812d7c5a4c36c9e4d743</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3004184/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3004184/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23876099$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19491313$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SEVERANCE, Emily G</creatorcontrib><creatorcontrib>DICKERSON, Faith B</creatorcontrib><creatorcontrib>VISCIDI, Raphael P</creatorcontrib><creatorcontrib>BOSSIS, Ioannis</creatorcontrib><creatorcontrib>STALLINGS, Cassie R</creatorcontrib><creatorcontrib>ORIGONI, Andrea E</creatorcontrib><creatorcontrib>SULLENS, Anne</creatorcontrib><creatorcontrib>YOLKEN, Robert H</creatorcontrib><title>Coronavirus Immunoreactivity in Individuals With a Recent Onset of Psychotic Symptoms</title><title>Schizophrenia bulletin</title><addtitle>Schizophr Bull</addtitle><description>Prenatal influenza exposure increases the risk for schizophrenia and brings to question how other respiratory viruses may contribute to neuropsychiatric disease etiopathology. Human coronaviruses cause respiratory infections that range in seriousness from common colds to severe acute respiratory syndrome. Like influenza, coronaviruses can be neurotropic. To test for associations between coronaviruses and serious mental disorders, we utilized a recently developed assay and measured immunoglobulin G (IgG) response against 4 human coronavirus strains (229E, HKU1, NL63, and OC43) in 106 patients with a recent onset of psychotic symptoms and 196 nonpsychiatric controls. We expressed results quantitatively as antibody levels and qualitatively as seroprevalence relative to a defined seropositivity cutoff value. Patient IgG levels were higher than controls for HKU1, NL63, and OC43, with HKU1 and NL63 both showing highly significant patient-to-control differences (HKU1, P ≤ .002; NL63, P ≤ .00001). All 4 coronaviruses were more seroprevalent in patients vs controls, with greatest intergroup differences observed for HKU1 (93% vs 77%, P ≤ .0001). HKU1 and NL63 associations with the patient group were further supported by multivariate analyses that controlled for age, gender, race, socioeconomic status, and smoking status (HKU1, odds ratio [OR] = 1.32, 95% confidence interval [CI] = 1.03-1.67, P ≤ .027; NL63, OR = 2.42, 95% CI = 1.25-4.66, P ≤ .008). Among patients, NL63 was associated with schizophrenia-spectrum (OR = 3.10, 95% CI = 1.27-7.58, P ≤ .013) but not mood disorders. HKU1 and NL63 coronavirus exposures may represent comorbid risk factors in neuropsychiatric disease. Future studies should explore links between the timing of coronavirus infections and subsequent development of schizophrenia and other disorders with psychotic symptoms.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Age</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Bipolar disorders</subject><subject>Common cold</subject><subject>Comorbidity</subject><subject>Coronavirus - immunology</subject><subject>Coronavirus Infections - complications</subject><subject>Coronavirus Infections - diagnosis</subject><subject>Coronavirus Infections - immunology</subject><subject>Female</subject><subject>Humans</subject><subject>Immunoglobulin G</subject><subject>Immunoglobulin G - blood</subject><subject>Immunoreactivity</subject><subject>Infection</subject><subject>Influenza</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mental disorders</subject><subject>Middle Aged</subject><subject>Mood</subject><subject>Mood disorders</subject><subject>Multivariate analysis</subject><subject>Prenatal experience</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Psychoses</subject><subject>Psychotic Disorders - immunology</subject><subject>Psychotic Disorders - virology</subject><subject>Races</subject><subject>Regular</subject><subject>Risk factors</subject><subject>SARS coronavirus</subject><subject>Schizophrenia</subject><subject>Severe acute respiratory syndrome</subject><subject>Smoking</subject><subject>Socio-economic aspects</subject><subject>Young Adult</subject><issn>0586-7614</issn><issn>1745-1701</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU2LFDEURYMoTs_o0q1kI86mnJdKUkk2gjR-NAyMqIPLkEoldqQqaZNUQ_97q-lm1I2rF3gnl_s4CL0g8IaAojfFbvt5vCn9Dnj7CK2IYLwhAshjtAIuu0Z0hF2gy1J-AhCmuvYpuiCKKUIJXaH7dcopmn3Ic8GbaZpjys7YGvahHnCIeBOH5T3MZiz4e6hbbPAXZ12s-C4WV3Hy-HM52G2qweKvh2lX01SeoSd--eCen-cVuv_w_tv6U3N793GzfnfbWCZEbXpYKg2i50woI3vrW-W4594L4J0ARzg1hLU9H5jxkrSDsNwwSzurHBsEo1fo7Sl3N_eTG461shn1LofJ5INOJuh_NzFs9Y-01xSAEXkMeH0OyOnX7ErVUyjWjaOJLs1FyxaEop0QC3n9X5IAlVxJqWBBmxNqcyolO_9QiIA-StMnafokbeFf_n3FH_psaQFenQFTrBl9NtGG8sC1VIoOlKK_Acrho6s</recordid><startdate>20110101</startdate><enddate>20110101</enddate><creator>SEVERANCE, Emily G</creator><creator>DICKERSON, Faith B</creator><creator>VISCIDI, Raphael P</creator><creator>BOSSIS, Ioannis</creator><creator>STALLINGS, Cassie R</creator><creator>ORIGONI, Andrea E</creator><creator>SULLENS, Anne</creator><creator>YOLKEN, Robert H</creator><general>Oxford University Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20110101</creationdate><title>Coronavirus Immunoreactivity in Individuals With a Recent Onset of Psychotic Symptoms</title><author>SEVERANCE, Emily G ; DICKERSON, Faith B ; VISCIDI, Raphael P ; BOSSIS, Ioannis ; STALLINGS, Cassie R ; ORIGONI, Andrea E ; SULLENS, Anne ; YOLKEN, Robert H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c477t-b0001d7b5479a8bcf29e5f5ff705670e153a142b5d4af812d7c5a4c36c9e4d743</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Adult and adolescent clinical studies</topic><topic>Age</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Bipolar disorders</topic><topic>Common cold</topic><topic>Comorbidity</topic><topic>Coronavirus - immunology</topic><topic>Coronavirus Infections - complications</topic><topic>Coronavirus Infections - diagnosis</topic><topic>Coronavirus Infections - immunology</topic><topic>Female</topic><topic>Humans</topic><topic>Immunoglobulin G</topic><topic>Immunoglobulin G - blood</topic><topic>Immunoreactivity</topic><topic>Infection</topic><topic>Influenza</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mental disorders</topic><topic>Middle Aged</topic><topic>Mood</topic><topic>Mood disorders</topic><topic>Multivariate analysis</topic><topic>Prenatal experience</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Psychoses</topic><topic>Psychotic Disorders - immunology</topic><topic>Psychotic Disorders - virology</topic><topic>Races</topic><topic>Regular</topic><topic>Risk factors</topic><topic>SARS coronavirus</topic><topic>Schizophrenia</topic><topic>Severe acute respiratory syndrome</topic><topic>Smoking</topic><topic>Socio-economic aspects</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SEVERANCE, Emily G</creatorcontrib><creatorcontrib>DICKERSON, Faith B</creatorcontrib><creatorcontrib>VISCIDI, Raphael P</creatorcontrib><creatorcontrib>BOSSIS, Ioannis</creatorcontrib><creatorcontrib>STALLINGS, Cassie R</creatorcontrib><creatorcontrib>ORIGONI, Andrea E</creatorcontrib><creatorcontrib>SULLENS, Anne</creatorcontrib><creatorcontrib>YOLKEN, Robert H</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Schizophrenia bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SEVERANCE, Emily G</au><au>DICKERSON, Faith B</au><au>VISCIDI, Raphael P</au><au>BOSSIS, Ioannis</au><au>STALLINGS, Cassie R</au><au>ORIGONI, Andrea E</au><au>SULLENS, Anne</au><au>YOLKEN, Robert H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Coronavirus Immunoreactivity in Individuals With a Recent Onset of Psychotic Symptoms</atitle><jtitle>Schizophrenia bulletin</jtitle><addtitle>Schizophr Bull</addtitle><date>2011-01-01</date><risdate>2011</risdate><volume>37</volume><issue>1</issue><spage>101</spage><epage>107</epage><pages>101-107</pages><issn>0586-7614</issn><eissn>1745-1701</eissn><coden>SCZBB3</coden><abstract>Prenatal influenza exposure increases the risk for schizophrenia and brings to question how other respiratory viruses may contribute to neuropsychiatric disease etiopathology. Human coronaviruses cause respiratory infections that range in seriousness from common colds to severe acute respiratory syndrome. Like influenza, coronaviruses can be neurotropic. To test for associations between coronaviruses and serious mental disorders, we utilized a recently developed assay and measured immunoglobulin G (IgG) response against 4 human coronavirus strains (229E, HKU1, NL63, and OC43) in 106 patients with a recent onset of psychotic symptoms and 196 nonpsychiatric controls. We expressed results quantitatively as antibody levels and qualitatively as seroprevalence relative to a defined seropositivity cutoff value. Patient IgG levels were higher than controls for HKU1, NL63, and OC43, with HKU1 and NL63 both showing highly significant patient-to-control differences (HKU1, P ≤ .002; NL63, P ≤ .00001). All 4 coronaviruses were more seroprevalent in patients vs controls, with greatest intergroup differences observed for HKU1 (93% vs 77%, P ≤ .0001). HKU1 and NL63 associations with the patient group were further supported by multivariate analyses that controlled for age, gender, race, socioeconomic status, and smoking status (HKU1, odds ratio [OR] = 1.32, 95% confidence interval [CI] = 1.03-1.67, P ≤ .027; NL63, OR = 2.42, 95% CI = 1.25-4.66, P ≤ .008). Among patients, NL63 was associated with schizophrenia-spectrum (OR = 3.10, 95% CI = 1.27-7.58, P ≤ .013) but not mood disorders. HKU1 and NL63 coronavirus exposures may represent comorbid risk factors in neuropsychiatric disease. Future studies should explore links between the timing of coronavirus infections and subsequent development of schizophrenia and other disorders with psychotic symptoms.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>19491313</pmid><doi>10.1093/schbul/sbp052</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Adolescent Adult Adult and adolescent clinical studies Age Aged Biological and medical sciences Bipolar disorders Common cold Comorbidity Coronavirus - immunology Coronavirus Infections - complications Coronavirus Infections - diagnosis Coronavirus Infections - immunology Female Humans Immunoglobulin G Immunoglobulin G - blood Immunoreactivity Infection Influenza Male Medical sciences Mental disorders Middle Aged Mood Mood disorders Multivariate analysis Prenatal experience Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychoses Psychotic Disorders - immunology Psychotic Disorders - virology Races Regular Risk factors SARS coronavirus Schizophrenia Severe acute respiratory syndrome Smoking Socio-economic aspects Young Adult |
title | Coronavirus Immunoreactivity in Individuals With a Recent Onset of Psychotic Symptoms |
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