Review: Magnetic Resonance Spectroscopy Studies of Pediatric Major Depressive Disorder
Introduction. This paper focuses on the application of Magnetic Resonance Spectroscopy (MRS) to the study of Major Depressive Disorder (MDD) in children and adolescents. Method. A literature search using the National Institutes of Health's PubMed database was conducted to identify indexed peer-...
Gespeichert in:
| Veröffentlicht in: | Depression Research and Treatment 2011, Vol.2011 (2011), p.340-352 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 352 |
|---|---|
| container_issue | 2011 |
| container_start_page | 340 |
| container_title | Depression Research and Treatment |
| container_volume | 2011 |
| creator | Kondo, Douglas G. Hellem, Tracy L. Sung, Young-Hoon Kim, Namkug Jeong, Eun-Kee DelMastro, Kristen K. Shi, Xianfeng Renshaw, Perry F. |
| description | Introduction. This paper focuses on the application of Magnetic Resonance Spectroscopy (MRS) to the study of Major Depressive Disorder (MDD) in children and adolescents. Method. A literature search using the National Institutes of Health's PubMed database was conducted to identify indexed peer-reviewed MRS studies in pediatric patients with MDD. Results. The literature search yielded 18 articles reporting original MRS data in pediatric MDD. Neurochemical alterations in Choline, Glutamate, and N-Acetyl Aspartate are associated with pediatric MDD, suggesting pathophysiologic continuity with adult MDD. Conclusions. The MRS literature in pediatric MDD is modest but growing. In studies that are methodologically comparable, the results have been consistent. Because it offers a noninvasive and repeatable measurement of relevant in vivo brain chemistry, MRS has the potential to provide insights into the pathophysiology of MDD as well as the mediators and moderators of treatment response. |
| doi_str_mv | 10.1155/2011/650450 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3003951</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><airiti_id>P20151224003_201112_201706230022_201706230022_340_352</airiti_id><sourcerecordid>822363157</sourcerecordid><originalsourceid>FETCH-LOGICAL-a4490-57eea46188bed8416fa4eedebfa09d5b8d2821cc9235c36da01b23a242e969df3</originalsourceid><addsrcrecordid>eNqFkt9rFDEQxxdRbKl98llZ8EFQzmYmyf7wQZBW28IVS6viW8gms22Ou82a7F7pf2-uW0_ti3mZhPnw5TvzTZY9B_YOQMoDZAAHhWRCskfZLrKazYDzH4-3d4SdbD_GBUtHiJIV7Gm2gwB1yepyN_t-QWtHN-_zM33V0eBMfkHRd7ozlF_2ZIbgo_H9bX45jNZRzH2bn5N1egiJPdMLH_Ij6gPF6NaUH7nog6XwLHvS6mWk_fu6l337_Onr4cls_uX49PDjfKaFSPZkSaRFAVXVkK0EFK0WRJaaVrPayqayWCEYUyOXhhdWM2iQaxRIdVHblu9lHybdfmxWZA11Q9BL1Qe30uFWee3Uv53OXasrv1acMV5LSAKv7wWC_zlSHNTKRUPLpe7Ij1FViLzgIMtEvnpALvwYujSdghJYiUmtTtTbiTJpcTFQu_UCTG0SU5vE1JRYol_-bX_L_s4nAW8m4Np1Vt-4_6i9mGBKCLV6C4sqjbHpz6e-dsEN7o__86QiAVGkpdwpAm5K-iyY9oQPHlwwxSXyXw8Vu90</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1710725139</pqid></control><display><type>article</type><title>Review: Magnetic Resonance Spectroscopy Studies of Pediatric Major Depressive Disorder</title><source>Wiley-Blackwell Open Access Titles</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><source>PubMed Central Open Access</source><creator>Kondo, Douglas G. ; Hellem, Tracy L. ; Sung, Young-Hoon ; Kim, Namkug ; Jeong, Eun-Kee ; DelMastro, Kristen K. ; Shi, Xianfeng ; Renshaw, Perry F.</creator><contributor>Piko, Bettina F.</contributor><creatorcontrib>Kondo, Douglas G. ; Hellem, Tracy L. ; Sung, Young-Hoon ; Kim, Namkug ; Jeong, Eun-Kee ; DelMastro, Kristen K. ; Shi, Xianfeng ; Renshaw, Perry F. ; Piko, Bettina F.</creatorcontrib><description>Introduction. This paper focuses on the application of Magnetic Resonance Spectroscopy (MRS) to the study of Major Depressive Disorder (MDD) in children and adolescents. Method. A literature search using the National Institutes of Health's PubMed database was conducted to identify indexed peer-reviewed MRS studies in pediatric patients with MDD. Results. The literature search yielded 18 articles reporting original MRS data in pediatric MDD. Neurochemical alterations in Choline, Glutamate, and N-Acetyl Aspartate are associated with pediatric MDD, suggesting pathophysiologic continuity with adult MDD. Conclusions. The MRS literature in pediatric MDD is modest but growing. In studies that are methodologically comparable, the results have been consistent. Because it offers a noninvasive and repeatable measurement of relevant in vivo brain chemistry, MRS has the potential to provide insights into the pathophysiology of MDD as well as the mediators and moderators of treatment response.</description><identifier>ISSN: 2090-1321</identifier><identifier>EISSN: 2090-133X</identifier><identifier>DOI: 10.1155/2011/650450</identifier><identifier>PMID: 21197097</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Limiteds</publisher><subject>Academic failure ; Biomarkers ; Brain research ; Child & adolescent psychiatry ; Child development ; Clinical trials ; Emotional disorders ; Medical imaging ; Medicine ; Mental depression ; Metabolites ; Mortality ; Neurobiology ; Neurosciences ; NMR ; Nuclear magnetic resonance ; Pediatrics ; Review ; Studies</subject><ispartof>Depression Research and Treatment, 2011, Vol.2011 (2011), p.340-352</ispartof><rights>Copyright © 2011 Douglas G. Kondo et al.</rights><rights>Copyright © 2011 Douglas G. Kondo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright © 2011 Douglas G. Kondo et al. 2011 Copyright © 2011 Douglas G. Kondo et al.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a4490-57eea46188bed8416fa4eedebfa09d5b8d2821cc9235c36da01b23a242e969df3</citedby><cites>FETCH-LOGICAL-a4490-57eea46188bed8416fa4eedebfa09d5b8d2821cc9235c36da01b23a242e969df3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3003951/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3003951/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,4010,27900,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21197097$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Piko, Bettina F.</contributor><creatorcontrib>Kondo, Douglas G.</creatorcontrib><creatorcontrib>Hellem, Tracy L.</creatorcontrib><creatorcontrib>Sung, Young-Hoon</creatorcontrib><creatorcontrib>Kim, Namkug</creatorcontrib><creatorcontrib>Jeong, Eun-Kee</creatorcontrib><creatorcontrib>DelMastro, Kristen K.</creatorcontrib><creatorcontrib>Shi, Xianfeng</creatorcontrib><creatorcontrib>Renshaw, Perry F.</creatorcontrib><title>Review: Magnetic Resonance Spectroscopy Studies of Pediatric Major Depressive Disorder</title><title>Depression Research and Treatment</title><addtitle>Depress Res Treat</addtitle><description>Introduction. This paper focuses on the application of Magnetic Resonance Spectroscopy (MRS) to the study of Major Depressive Disorder (MDD) in children and adolescents. Method. A literature search using the National Institutes of Health's PubMed database was conducted to identify indexed peer-reviewed MRS studies in pediatric patients with MDD. Results. The literature search yielded 18 articles reporting original MRS data in pediatric MDD. Neurochemical alterations in Choline, Glutamate, and N-Acetyl Aspartate are associated with pediatric MDD, suggesting pathophysiologic continuity with adult MDD. Conclusions. The MRS literature in pediatric MDD is modest but growing. In studies that are methodologically comparable, the results have been consistent. Because it offers a noninvasive and repeatable measurement of relevant in vivo brain chemistry, MRS has the potential to provide insights into the pathophysiology of MDD as well as the mediators and moderators of treatment response.</description><subject>Academic failure</subject><subject>Biomarkers</subject><subject>Brain research</subject><subject>Child & adolescent psychiatry</subject><subject>Child development</subject><subject>Clinical trials</subject><subject>Emotional disorders</subject><subject>Medical imaging</subject><subject>Medicine</subject><subject>Mental depression</subject><subject>Metabolites</subject><subject>Mortality</subject><subject>Neurobiology</subject><subject>Neurosciences</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Pediatrics</subject><subject>Review</subject><subject>Studies</subject><issn>2090-1321</issn><issn>2090-133X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkt9rFDEQxxdRbKl98llZ8EFQzmYmyf7wQZBW28IVS6viW8gms22Ou82a7F7pf2-uW0_ti3mZhPnw5TvzTZY9B_YOQMoDZAAHhWRCskfZLrKazYDzH4-3d4SdbD_GBUtHiJIV7Gm2gwB1yepyN_t-QWtHN-_zM33V0eBMfkHRd7ozlF_2ZIbgo_H9bX45jNZRzH2bn5N1egiJPdMLH_Ij6gPF6NaUH7nog6XwLHvS6mWk_fu6l337_Onr4cls_uX49PDjfKaFSPZkSaRFAVXVkK0EFK0WRJaaVrPayqayWCEYUyOXhhdWM2iQaxRIdVHblu9lHybdfmxWZA11Q9BL1Qe30uFWee3Uv53OXasrv1acMV5LSAKv7wWC_zlSHNTKRUPLpe7Ij1FViLzgIMtEvnpALvwYujSdghJYiUmtTtTbiTJpcTFQu_UCTG0SU5vE1JRYol_-bX_L_s4nAW8m4Np1Vt-4_6i9mGBKCLV6C4sqjbHpz6e-dsEN7o__86QiAVGkpdwpAm5K-iyY9oQPHlwwxSXyXw8Vu90</recordid><startdate>2011</startdate><enddate>2011</enddate><creator>Kondo, Douglas G.</creator><creator>Hellem, Tracy L.</creator><creator>Sung, Young-Hoon</creator><creator>Kim, Namkug</creator><creator>Jeong, Eun-Kee</creator><creator>DelMastro, Kristen K.</creator><creator>Shi, Xianfeng</creator><creator>Renshaw, Perry F.</creator><general>Hindawi Limiteds</general><general>Hindawi Puplishing Corporation</general><general>Hindawi Publishing Corporation</general><general>Hindawi Limited</general><scope>188</scope><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>4U-</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88G</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M2M</scope><scope>NAPCQ</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>2011</creationdate><title>Review: Magnetic Resonance Spectroscopy Studies of Pediatric Major Depressive Disorder</title><author>Kondo, Douglas G. ; Hellem, Tracy L. ; Sung, Young-Hoon ; Kim, Namkug ; Jeong, Eun-Kee ; DelMastro, Kristen K. ; Shi, Xianfeng ; Renshaw, Perry F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a4490-57eea46188bed8416fa4eedebfa09d5b8d2821cc9235c36da01b23a242e969df3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Academic failure</topic><topic>Biomarkers</topic><topic>Brain research</topic><topic>Child & adolescent psychiatry</topic><topic>Child development</topic><topic>Clinical trials</topic><topic>Emotional disorders</topic><topic>Medical imaging</topic><topic>Medicine</topic><topic>Mental depression</topic><topic>Metabolites</topic><topic>Mortality</topic><topic>Neurobiology</topic><topic>Neurosciences</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Pediatrics</topic><topic>Review</topic><topic>Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kondo, Douglas G.</creatorcontrib><creatorcontrib>Hellem, Tracy L.</creatorcontrib><creatorcontrib>Sung, Young-Hoon</creatorcontrib><creatorcontrib>Kim, Namkug</creatorcontrib><creatorcontrib>Jeong, Eun-Kee</creatorcontrib><creatorcontrib>DelMastro, Kristen K.</creatorcontrib><creatorcontrib>Shi, Xianfeng</creatorcontrib><creatorcontrib>Renshaw, Perry F.</creatorcontrib><collection>Airiti Library</collection><collection>الدوريات العلمية والإحصائية - e-Marefa Academic and Statistical Periodicals</collection><collection>معرفة - المحتوى العربي الأكاديمي المتكامل - e-Marefa Academic Complete</collection><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>University Readers</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Psychology Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Depression Research and Treatment</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kondo, Douglas G.</au><au>Hellem, Tracy L.</au><au>Sung, Young-Hoon</au><au>Kim, Namkug</au><au>Jeong, Eun-Kee</au><au>DelMastro, Kristen K.</au><au>Shi, Xianfeng</au><au>Renshaw, Perry F.</au><au>Piko, Bettina F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Review: Magnetic Resonance Spectroscopy Studies of Pediatric Major Depressive Disorder</atitle><jtitle>Depression Research and Treatment</jtitle><addtitle>Depress Res Treat</addtitle><date>2011</date><risdate>2011</risdate><volume>2011</volume><issue>2011</issue><spage>340</spage><epage>352</epage><pages>340-352</pages><issn>2090-1321</issn><eissn>2090-133X</eissn><abstract>Introduction. This paper focuses on the application of Magnetic Resonance Spectroscopy (MRS) to the study of Major Depressive Disorder (MDD) in children and adolescents. Method. A literature search using the National Institutes of Health's PubMed database was conducted to identify indexed peer-reviewed MRS studies in pediatric patients with MDD. Results. The literature search yielded 18 articles reporting original MRS data in pediatric MDD. Neurochemical alterations in Choline, Glutamate, and N-Acetyl Aspartate are associated with pediatric MDD, suggesting pathophysiologic continuity with adult MDD. Conclusions. The MRS literature in pediatric MDD is modest but growing. In studies that are methodologically comparable, the results have been consistent. Because it offers a noninvasive and repeatable measurement of relevant in vivo brain chemistry, MRS has the potential to provide insights into the pathophysiology of MDD as well as the mediators and moderators of treatment response.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Limiteds</pub><pmid>21197097</pmid><doi>10.1155/2011/650450</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2090-1321 |
| ispartof | Depression Research and Treatment, 2011, Vol.2011 (2011), p.340-352 |
| issn | 2090-1321 2090-133X |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3003951 |
| source | Wiley-Blackwell Open Access Titles; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection; PubMed Central Open Access |
| subjects | Academic failure Biomarkers Brain research Child & adolescent psychiatry Child development Clinical trials Emotional disorders Medical imaging Medicine Mental depression Metabolites Mortality Neurobiology Neurosciences NMR Nuclear magnetic resonance Pediatrics Review Studies |
| title | Review: Magnetic Resonance Spectroscopy Studies of Pediatric Major Depressive Disorder |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-30T19%3A54%3A47IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Review:%20Magnetic%20Resonance%20Spectroscopy%20Studies%20of%20Pediatric%20Major%20Depressive%20Disorder&rft.jtitle=Depression%20Research%20and%20Treatment&rft.au=Kondo,%20Douglas%20G.&rft.date=2011&rft.volume=2011&rft.issue=2011&rft.spage=340&rft.epage=352&rft.pages=340-352&rft.issn=2090-1321&rft.eissn=2090-133X&rft_id=info:doi/10.1155/2011/650450&rft_dat=%3Cproquest_pubme%3E822363157%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1710725139&rft_id=info:pmid/21197097&rft_airiti_id=P20151224003_201112_201706230022_201706230022_340_352&rfr_iscdi=true |