Rapid Intradermal Delivery of Liquid Formulations Using a Hollow Microstructured Array

Purpose The purpose of this work is to demonstrate rapid intradermal delivery of up to 1.5 mL of formulation using a hollow microneedle delivery device designed for self-application. Methods 3M's hollow Microstructured Transdermal System (hMTS) was applied to domestic swine to demonstrate deliv...

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Veröffentlicht in:	Pharmaceutical research 2011-01, Vol.28 (1), p.31-40
Hauptverfasser:	Burton, Scott A, Ng, Chin-Yee, Simmers, Ryan, Moeckly, Craig, Brandwein, David, Gilbert, Tom, Johnson, Nathan, Brown, Ken, Alston, Tesha, Prochnow, Gayatri, Siebenaler, Kris, Hansen, Kris
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - administration & dosage Antibodies, Monoclonal - immunology Bioavailability Biochemistry Biomedical and Life Sciences Biomedical Engineering and Bioengineering Biomedicine Chemistry, Pharmaceutical Chromatography, High Pressure Liquid Drug Delivery Systems - instrumentation Drug Delivery Systems - methods Enzyme-Linked Immunosorbent Assay Equipment Design Female Guinea Pigs Hogs hollow microstructures Injections, Intradermal intradermal Male Medical Law Microinjections - instrumentation Microinjections - methods microneedles Microstructure MTS Needles Pharmaceutical Preparations - administration & dosage Pharmaceutical Preparations - blood Pharmaceutical Preparations - chemistry Pharmaceutical sciences Pharmacology/Toxicology Pharmacy Research Paper Skin - drug effects Skin - metabolism Swine Time Factors transdermal drug delivery Transdermal medication
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