Rapid Intradermal Delivery of Liquid Formulations Using a Hollow Microstructured Array
Purpose The purpose of this work is to demonstrate rapid intradermal delivery of up to 1.5 mL of formulation using a hollow microneedle delivery device designed for self-application. Methods 3M's hollow Microstructured Transdermal System (hMTS) was applied to domestic swine to demonstrate deliv...
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| Veröffentlicht in: | Pharmaceutical research 2011-01, Vol.28 (1), p.31-40 |
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| creator | Burton, Scott A Ng, Chin-Yee Simmers, Ryan Moeckly, Craig Brandwein, David Gilbert, Tom Johnson, Nathan Brown, Ken Alston, Tesha Prochnow, Gayatri Siebenaler, Kris Hansen, Kris |
| description | Purpose The purpose of this work is to demonstrate rapid intradermal delivery of up to 1.5 mL of formulation using a hollow microneedle delivery device designed for self-application. Methods 3M's hollow Microstructured Transdermal System (hMTS) was applied to domestic swine to demonstrate delivery of a variety of formulations including small molecule salts and proteins. Blood samples were collected after delivery and analyzed via HPLC or ELISA to provide a PK profile for the delivered drug. Site evaluations were conducted post delivery to determine skin tolerability. Results Up to 1.5 mL of formulation was infused into swine at a max rate of approximately 0.25 mL/min. A red blotch, the size of the hMTS array, was observed immediately after patch removal, but had faded so as to be almost indistinguishable 10 min post-patch removal. One-mL deliveries of commercial formulations of naloxone hydrochloride and human growth hormone and a formulation of equine anti-tetanus toxin were completed in swine. With few notable differences, the resulting PK profiles were similar to those achieved following subcutaneous injection of these formulations. Conclusions 3M's hMTS can provide rapid, intradermal delivery of 300-1,500 µL of liquid formulations of small molecules salts and proteins, compounds not typically compatible with passive transdermal delivery. |
| doi_str_mv | 10.1007/s11095-010-0177-8 |
| format | Article |
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Methods 3M's hollow Microstructured Transdermal System (hMTS) was applied to domestic swine to demonstrate delivery of a variety of formulations including small molecule salts and proteins. Blood samples were collected after delivery and analyzed via HPLC or ELISA to provide a PK profile for the delivered drug. Site evaluations were conducted post delivery to determine skin tolerability. Results Up to 1.5 mL of formulation was infused into swine at a max rate of approximately 0.25 mL/min. A red blotch, the size of the hMTS array, was observed immediately after patch removal, but had faded so as to be almost indistinguishable 10 min post-patch removal. One-mL deliveries of commercial formulations of naloxone hydrochloride and human growth hormone and a formulation of equine anti-tetanus toxin were completed in swine. With few notable differences, the resulting PK profiles were similar to those achieved following subcutaneous injection of these formulations. Conclusions 3M's hMTS can provide rapid, intradermal delivery of 300-1,500 µL of liquid formulations of small molecules salts and proteins, compounds not typically compatible with passive transdermal delivery.</description><identifier>ISSN: 0724-8741</identifier><identifier>EISSN: 1573-904X</identifier><identifier>DOI: 10.1007/s11095-010-0177-8</identifier><identifier>PMID: 20582455</identifier><language>eng</language><publisher>Boston: Boston : Springer US</publisher><subject>Animals ; Antibodies, Monoclonal - administration & dosage ; Antibodies, Monoclonal - immunology ; Bioavailability ; Biochemistry ; Biomedical and Life Sciences ; Biomedical Engineering and Bioengineering ; Biomedicine ; Chemistry, Pharmaceutical ; Chromatography, High Pressure Liquid ; Drug Delivery Systems - instrumentation ; Drug Delivery Systems - methods ; Enzyme-Linked Immunosorbent Assay ; Equipment Design ; Female ; Guinea Pigs ; Hogs ; hollow microstructures ; Injections, Intradermal ; intradermal ; Male ; Medical Law ; Microinjections - instrumentation ; Microinjections - methods ; microneedles ; Microstructure ; MTS ; Needles ; Pharmaceutical Preparations - administration & dosage ; Pharmaceutical Preparations - blood ; Pharmaceutical Preparations - chemistry ; Pharmaceutical sciences ; Pharmacology/Toxicology ; Pharmacy ; Research Paper ; Skin - drug effects ; Skin - metabolism ; Swine ; Time Factors ; transdermal drug delivery ; Transdermal medication</subject><ispartof>Pharmaceutical research, 2011-01, Vol.28 (1), p.31-40</ispartof><rights>The Author(s) 2010</rights><rights>Springer Science+Business Media, LLC 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c558t-c49e478c032bde56a977ed83c4cd9bcb49578fde8d1db545de0c82b1c0227f173</citedby><cites>FETCH-LOGICAL-c558t-c49e478c032bde56a977ed83c4cd9bcb49578fde8d1db545de0c82b1c0227f173</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11095-010-0177-8$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11095-010-0177-8$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,315,781,785,886,27926,27927,41490,42559,51321</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20582455$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Burton, Scott A</creatorcontrib><creatorcontrib>Ng, Chin-Yee</creatorcontrib><creatorcontrib>Simmers, Ryan</creatorcontrib><creatorcontrib>Moeckly, Craig</creatorcontrib><creatorcontrib>Brandwein, David</creatorcontrib><creatorcontrib>Gilbert, Tom</creatorcontrib><creatorcontrib>Johnson, Nathan</creatorcontrib><creatorcontrib>Brown, Ken</creatorcontrib><creatorcontrib>Alston, Tesha</creatorcontrib><creatorcontrib>Prochnow, Gayatri</creatorcontrib><creatorcontrib>Siebenaler, Kris</creatorcontrib><creatorcontrib>Hansen, Kris</creatorcontrib><title>Rapid Intradermal Delivery of Liquid Formulations Using a Hollow Microstructured Array</title><title>Pharmaceutical research</title><addtitle>Pharm Res</addtitle><addtitle>Pharm Res</addtitle><description>Purpose The purpose of this work is to demonstrate rapid intradermal delivery of up to 1.5 mL of formulation using a hollow microneedle delivery device designed for self-application. Methods 3M's hollow Microstructured Transdermal System (hMTS) was applied to domestic swine to demonstrate delivery of a variety of formulations including small molecule salts and proteins. Blood samples were collected after delivery and analyzed via HPLC or ELISA to provide a PK profile for the delivered drug. Site evaluations were conducted post delivery to determine skin tolerability. Results Up to 1.5 mL of formulation was infused into swine at a max rate of approximately 0.25 mL/min. A red blotch, the size of the hMTS array, was observed immediately after patch removal, but had faded so as to be almost indistinguishable 10 min post-patch removal. One-mL deliveries of commercial formulations of naloxone hydrochloride and human growth hormone and a formulation of equine anti-tetanus toxin were completed in swine. With few notable differences, the resulting PK profiles were similar to those achieved following subcutaneous injection of these formulations. Conclusions 3M's hMTS can provide rapid, intradermal delivery of 300-1,500 µL of liquid formulations of small molecules salts and proteins, compounds not typically compatible with passive transdermal delivery.</description><subject>Animals</subject><subject>Antibodies, Monoclonal - administration & dosage</subject><subject>Antibodies, Monoclonal - immunology</subject><subject>Bioavailability</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedical Engineering and Bioengineering</subject><subject>Biomedicine</subject><subject>Chemistry, Pharmaceutical</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Drug Delivery Systems - instrumentation</subject><subject>Drug Delivery Systems - methods</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Equipment Design</subject><subject>Female</subject><subject>Guinea Pigs</subject><subject>Hogs</subject><subject>hollow microstructures</subject><subject>Injections, Intradermal</subject><subject>intradermal</subject><subject>Male</subject><subject>Medical Law</subject><subject>Microinjections - instrumentation</subject><subject>Microinjections - methods</subject><subject>microneedles</subject><subject>Microstructure</subject><subject>MTS</subject><subject>Needles</subject><subject>Pharmaceutical Preparations - administration & dosage</subject><subject>Pharmaceutical Preparations - blood</subject><subject>Pharmaceutical Preparations - chemistry</subject><subject>Pharmaceutical sciences</subject><subject>Pharmacology/Toxicology</subject><subject>Pharmacy</subject><subject>Research Paper</subject><subject>Skin - drug effects</subject><subject>Skin - metabolism</subject><subject>Swine</subject><subject>Time Factors</subject><subject>transdermal drug delivery</subject><subject>Transdermal medication</subject><issn>0724-8741</issn><issn>1573-904X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9UU1vFSEUJUZjn9Uf4EaJG1djLwwUZmPS1NY2eY2J-ow7wgDzpGGGV5hp8_69TKbWj4ULAsn5uPdwEHpJ4B0BEEeZEGh4BQTKEaKSj9CKcFFXDbDvj9EKBGWVFIwcoGc5XwOAJA17ig4ocEkZ5yv07bPeeYsvhzFp61KvA_7ggr91aY9jh9f-ZirweUz9FPTo45DxJvthizW-iCHEO3zlTYp5TJMZp-QsPklJ75-jJ50O2b24vw_R5vzs6-lFtf708fL0ZF0ZzuVYGdY4JqSBmrbW8WPdCOGsrA0ztmlNyxouZGedtMS2nHHrwEjaEgOUio6I-hC9X3x3U9s7a9ycI6hd8r1OexW1V38jg_-htvFW1QC1pLPB23uDFG8ml0fV-2xcCHpwccpKUhDNPK0w3_zDvI5TGko6JYkUkhwTWkhkIc1_kpPrHlYhoObO1NKZKp2puTMli-bVnxkeFL9KKgS6EHKBhq1Lvyf_z_X1Iup0VHqbfFabLxRIDaShdH78BIUzrI0</recordid><startdate>20110101</startdate><enddate>20110101</enddate><creator>Burton, Scott A</creator><creator>Ng, Chin-Yee</creator><creator>Simmers, Ryan</creator><creator>Moeckly, Craig</creator><creator>Brandwein, David</creator><creator>Gilbert, Tom</creator><creator>Johnson, Nathan</creator><creator>Brown, Ken</creator><creator>Alston, Tesha</creator><creator>Prochnow, Gayatri</creator><creator>Siebenaler, Kris</creator><creator>Hansen, Kris</creator><general>Boston : Springer US</general><general>Springer US</general><general>Springer Nature B.V</general><scope>FBQ</scope><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20110101</creationdate><title>Rapid Intradermal Delivery of Liquid Formulations Using a Hollow Microstructured Array</title><author>Burton, Scott A ; Ng, Chin-Yee ; Simmers, Ryan ; Moeckly, Craig ; Brandwein, David ; Gilbert, Tom ; Johnson, Nathan ; Brown, Ken ; Alston, Tesha ; Prochnow, Gayatri ; Siebenaler, Kris ; Hansen, Kris</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c558t-c49e478c032bde56a977ed83c4cd9bcb49578fde8d1db545de0c82b1c0227f173</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Animals</topic><topic>Antibodies, Monoclonal - administration & dosage</topic><topic>Antibodies, Monoclonal - immunology</topic><topic>Bioavailability</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedical Engineering and Bioengineering</topic><topic>Biomedicine</topic><topic>Chemistry, Pharmaceutical</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Drug Delivery Systems - instrumentation</topic><topic>Drug Delivery Systems - methods</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Equipment Design</topic><topic>Female</topic><topic>Guinea Pigs</topic><topic>Hogs</topic><topic>hollow microstructures</topic><topic>Injections, Intradermal</topic><topic>intradermal</topic><topic>Male</topic><topic>Medical Law</topic><topic>Microinjections - instrumentation</topic><topic>Microinjections - methods</topic><topic>microneedles</topic><topic>Microstructure</topic><topic>MTS</topic><topic>Needles</topic><topic>Pharmaceutical Preparations - administration & dosage</topic><topic>Pharmaceutical Preparations - blood</topic><topic>Pharmaceutical Preparations - chemistry</topic><topic>Pharmaceutical sciences</topic><topic>Pharmacology/Toxicology</topic><topic>Pharmacy</topic><topic>Research Paper</topic><topic>Skin - drug effects</topic><topic>Skin - metabolism</topic><topic>Swine</topic><topic>Time Factors</topic><topic>transdermal drug delivery</topic><topic>Transdermal medication</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Burton, Scott A</creatorcontrib><creatorcontrib>Ng, Chin-Yee</creatorcontrib><creatorcontrib>Simmers, Ryan</creatorcontrib><creatorcontrib>Moeckly, Craig</creatorcontrib><creatorcontrib>Brandwein, David</creatorcontrib><creatorcontrib>Gilbert, Tom</creatorcontrib><creatorcontrib>Johnson, Nathan</creatorcontrib><creatorcontrib>Brown, Ken</creatorcontrib><creatorcontrib>Alston, Tesha</creatorcontrib><creatorcontrib>Prochnow, Gayatri</creatorcontrib><creatorcontrib>Siebenaler, Kris</creatorcontrib><creatorcontrib>Hansen, Kris</creatorcontrib><collection>AGRIS</collection><collection>Springer Nature OA/Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Pharmaceutical research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Burton, Scott A</au><au>Ng, Chin-Yee</au><au>Simmers, Ryan</au><au>Moeckly, Craig</au><au>Brandwein, David</au><au>Gilbert, Tom</au><au>Johnson, Nathan</au><au>Brown, Ken</au><au>Alston, Tesha</au><au>Prochnow, Gayatri</au><au>Siebenaler, Kris</au><au>Hansen, Kris</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Rapid Intradermal Delivery of Liquid Formulations Using a Hollow Microstructured Array</atitle><jtitle>Pharmaceutical research</jtitle><stitle>Pharm Res</stitle><addtitle>Pharm Res</addtitle><date>2011-01-01</date><risdate>2011</risdate><volume>28</volume><issue>1</issue><spage>31</spage><epage>40</epage><pages>31-40</pages><issn>0724-8741</issn><eissn>1573-904X</eissn><abstract>Purpose The purpose of this work is to demonstrate rapid intradermal delivery of up to 1.5 mL of formulation using a hollow microneedle delivery device designed for self-application. Methods 3M's hollow Microstructured Transdermal System (hMTS) was applied to domestic swine to demonstrate delivery of a variety of formulations including small molecule salts and proteins. Blood samples were collected after delivery and analyzed via HPLC or ELISA to provide a PK profile for the delivered drug. Site evaluations were conducted post delivery to determine skin tolerability. Results Up to 1.5 mL of formulation was infused into swine at a max rate of approximately 0.25 mL/min. A red blotch, the size of the hMTS array, was observed immediately after patch removal, but had faded so as to be almost indistinguishable 10 min post-patch removal. One-mL deliveries of commercial formulations of naloxone hydrochloride and human growth hormone and a formulation of equine anti-tetanus toxin were completed in swine. With few notable differences, the resulting PK profiles were similar to those achieved following subcutaneous injection of these formulations. Conclusions 3M's hMTS can provide rapid, intradermal delivery of 300-1,500 µL of liquid formulations of small molecules salts and proteins, compounds not typically compatible with passive transdermal delivery.</abstract><cop>Boston</cop><pub>Boston : Springer US</pub><pmid>20582455</pmid><doi>10.1007/s11095-010-0177-8</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; SpringerNature Journals |
| subjects | Animals Antibodies, Monoclonal - administration & dosage Antibodies, Monoclonal - immunology Bioavailability Biochemistry Biomedical and Life Sciences Biomedical Engineering and Bioengineering Biomedicine Chemistry, Pharmaceutical Chromatography, High Pressure Liquid Drug Delivery Systems - instrumentation Drug Delivery Systems - methods Enzyme-Linked Immunosorbent Assay Equipment Design Female Guinea Pigs Hogs hollow microstructures Injections, Intradermal intradermal Male Medical Law Microinjections - instrumentation Microinjections - methods microneedles Microstructure MTS Needles Pharmaceutical Preparations - administration & dosage Pharmaceutical Preparations - blood Pharmaceutical Preparations - chemistry Pharmaceutical sciences Pharmacology/Toxicology Pharmacy Research Paper Skin - drug effects Skin - metabolism Swine Time Factors transdermal drug delivery Transdermal medication |
| title | Rapid Intradermal Delivery of Liquid Formulations Using a Hollow Microstructured Array |
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