Inactivation of eukaryotic initiation factor 5A (eIF5A) by specific acetylation of its hypusine residue by spermidine/spermine acetyltransferase 1 (SSAT1)

eIF5A (eukaryotic translation initiation factor 5A) is the only cellular protein containing hypusine [Nϵ-(4-amino-2-hydroxybutyl)lysine]. eIF5A is activated by the post-translational synthesis of hypusine and the hypusine modification is essential for cell proliferation. In the present study, we rep...

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Veröffentlicht in:	Biochemical journal 2011-01, Vol.433 (1), p.205-213
Hauptverfasser:	Lee, Seung Bum, Park, Jong Hwan, Folk, John E, Deck, Jason A, Pegg, Anthony E, Sokabe, Masaaki, Fraser, Christopher S, Park, Myung Hee
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Acetyltransferases - metabolism Animals Cattle Cell Line, Tumor Eukaryotic Translation Initiation Factor 5A Humans Lysine - analogs & derivatives Lysine - metabolism Peptide Initiation Factors - metabolism Protein Binding RNA-Binding Proteins - metabolism
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