Hdac1 and Hdac2 Act Redundantly to Control p63 and p53 Functions in Epidermal Progenitor Cells

Epidermal and hair follicle development from surface ectodermal progenitor cells requires coordinated changes in gene expression. Histone deacetylases alter gene expression programs through modification of chromatin and transcription factors. We find that deletion of ectodermal Hdac1 and Hdac2 resul...

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Veröffentlicht in:	Developmental cell 2010-12, Vol.19 (6), p.807-818
Hauptverfasser:	LeBoeuf, Matthew, Terrell, Anne, Trivedi, Sohum, Sinha, Satrajit, Epstein, Jonathan A., Olson, Eric N., Morrisey, Edward E., Millar, Sarah E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Animals Apoptosis - genetics Apoptosis - physiology Base Sequence Biological and medical sciences Cell Differentiation - genetics Cell Differentiation - physiology Cell differentiation, maturation, development, hematopoiesis Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Cyclin-Dependent Kinase Inhibitor p16 - deficiency Cyclin-Dependent Kinase Inhibitor p16 - genetics Cyclin-Dependent Kinase Inhibitor p16 - physiology Cyclin-Dependent Kinase Inhibitor p21 - genetics Cyclin-Dependent Kinase Inhibitor p21 - metabolism DNA Primers - genetics Embryonic Stem Cells - cytology Embryonic Stem Cells - metabolism Epidermis - abnormalities Epidermis - embryology Epidermis - metabolism Female Fundamental and applied biological sciences. Psychology Gene Expression Regulation, Developmental Hair Follicle - abnormalities Hair Follicle - embryology Hair Follicle - metabolism Histone Deacetylase 1 - deficiency Histone Deacetylase 1 - genetics Histone Deacetylase 1 - physiology Histone Deacetylase 2 - deficiency Histone Deacetylase 2 - genetics Histone Deacetylase 2 - physiology Humans Keratinocytes - cytology Keratinocytes - metabolism Mice Mice, Knockout Mice, Transgenic Models, Biological Molecular and cellular biology Phosphoproteins - genetics Phosphoproteins - physiology Pregnancy Tissue Distribution Trans-Activators - genetics Trans-Activators - physiology Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - physiology Up-Regulation
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