Inflammation-induced tumorigenesis in the colon is regulated by caspase-1 and NLRC4

Chronic inflammation is a known risk factor for tumorigenesis, yet the precise mechanism of this association is currently unknown. The inflammasome, a multiprotein complex formed by NOD-like receptor (NLR) family members, has recently been shown to orchestrate multiple innate and adaptive immune res...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2010-12, Vol.107 (50), p.21635-21640
Hauptverfasser:	Hu, Bo, Elinav, Eran, Huber, Samuel, Booth, Carmen J., Strowig, Till, Jin, Chengcheng, Eisenbarth, Stephanie C., Flavell, Richard A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Apoptosis Regulatory Proteins - genetics Apoptosis Regulatory Proteins - metabolism Biological Sciences Calcium-Binding Proteins - genetics Calcium-Binding Proteins - metabolism Cancer Caspase 1 - genetics Caspase 1 - metabolism Cellular biology Colitis Colitis - chemically induced Colitis - metabolism Colitis - pathology Colon - metabolism Colon - pathology Colonic Neoplasms - metabolism Colonic Neoplasms - pathology Colorectal cancer Colorectal carcinoma Dextran Sulfate - adverse effects Epithelial cells Humans Immune system Inflammation Inflammation - metabolism Inflammation - pathology Inflammatory diseases Messenger RNA Mice Mice, Inbred C57BL Mice, Knockout Proteins Risk factors Rodents Sodium sulfate T lymphocytes Tumor burden Tumors
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