In vitro activity of cethromycin against Burkholderia pseudomallei and investigation of mechanism of resistance

most Burkholderia pseudomallei strains are intrinsically resistant to macrolides, mainly due to AmrAB-OprA- and/or BpeAB-OprB-mediated efflux. We assessed the in vitro anti-B. pseudomallei efficacy of cethromycin, a novel ketolide with broad-spectrum activity against Gram-negative and Gram-positive...

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Veröffentlicht in:	Journal of antimicrobial chemotherapy 2011-01, Vol.66 (1), p.73-78
Hauptverfasser:	MIMA, Takehiko, SCHWEIZER, Herbert P, XU, Ze-Qi
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - pharmacology Antibiotics Antibiotics. Antiinfectious agents. Antiparasitic agents Bacteria Bacterial diseases Biological and medical sciences Burkholderia pseudomallei Burkholderia pseudomallei - drug effects DNA Mutational Analysis Drug resistance Drug Resistance, Bacterial Gene Deletion Gene Expression Regulation, Bacterial Genetic Complementation Test Human bacterial diseases Humans Infectious diseases Ketolides - pharmacology Medical sciences Melioidosis Membrane Transport Proteins - genetics Microbial Sensitivity Tests Microbial Viability - drug effects Mutation Original Research Pharmacology Pharmacology. Drug treatments Tropical bacterial diseases
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