Design of a minimal silencer for the silent mating-type locus HML of Saccharomyces cerevisiae

The silent mating-type loci HML and HMR of Saccharomyces cerevisiae contain mating-type information that is permanently repressed. This silencing is mediated by flanking sequence elements, the E- and I-silencers. They contain combinations of binding sites for the proteins Rap1, Abf1 and Sum1 as well...

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Veröffentlicht in:	Nucleic acids research 2010-12, Vol.38 (22), p.7991-8000
Hauptverfasser:	Weber, Jan M, Ehrenhofer-Murray, Ann E
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Sites Gene Expression Regulation, Fungal Gene Regulation, Chromatin and Epigenetics Gene Silencing Genes, Mating Type, Fungal Genetic Loci Histone-Lysine N-Methyltransferase - genetics Mutation Nuclear Proteins - genetics Oligonucleotides - chemistry Origin Recognition Complex - metabolism Saccharomyces cerevisiae Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae Proteins - genetics Saccharomyces cerevisiae Proteins - metabolism Silencer Elements, Transcriptional Silent Information Regulator Proteins, Saccharomyces cerevisiae - genetics Telomere-Binding Proteins - metabolism Transcription Factors - metabolism
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