Inhibitory Effect of Silibinin against Azoxymethane-Induced Colon Tumorigenesis in A/J Mice

Colorectal cancer is the second leading cause of cancer-associated deaths, which suggests that more effort is needed to prevent/control this disease. Herein, for the first time, we investigate in vivo the efficacy of silibinin against azoxymethane-induced colon tumorigenesis in A/J mice. Five-week-o...

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Veröffentlicht in:	Clinical cancer research 2010-09, Vol.16 (18), p.4595-4606
Hauptverfasser:	RAVICHANDRAN, Kameswaran, VELMURUGAN, Balaiya, GU, Mallikarjuna, SINGH, Rana P, AGARWAL, Rajesh
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenic Proteins - metabolism Animals Antineoplastic agents Antineoplastic Agents - pharmacology Antioxidants - pharmacology Antioxidants - therapeutic use Apoptosis - drug effects Azoxymethane Biological and medical sciences Carcinogens Carcinoma - chemically induced Carcinoma - pathology Carcinoma - prevention & control Cell Proliferation - drug effects Colonic Neoplasms - chemically induced Colonic Neoplasms - pathology Colonic Neoplasms - prevention & control Cytoprotection - drug effects Dose-Response Relationship, Drug Down-Regulation - drug effects Drug Evaluation, Preclinical Inflammation Mediators - metabolism Male Medical sciences Mice Mice, Inbred Strains Pharmacology. Drug treatments Silymarin - pharmacology Silymarin - therapeutic use
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