Receptor for activated C kinase 1 stimulates nascent polypeptide-dependent translation arrest
Nascent peptide‐dependent translation arrest is crucial for the quality control of eukaryotic gene expression. Here we show that the receptor for activated C kinase 1 (RACK1) participates in nascent peptide‐dependent translation arrest, and that its binding to the 40S subunit is crucial for this. Tr...
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| Veröffentlicht in: | EMBO reports 2010-12, Vol.11 (12), p.956-961 |
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| creator | Kuroha, Kazushige Akamatsu, Mayuko Dimitrova, Lyudmila Ito, Takehiko Kato, Yuki Shirahige, Katsuhiko Inada, Toshifumi |
| description | Nascent peptide‐dependent translation arrest is crucial for the quality control of eukaryotic gene expression. Here we show that the receptor for activated C kinase 1 (RACK1) participates in nascent peptide‐dependent translation arrest, and that its binding to the 40S subunit is crucial for this. Translation arrest by a nascent peptide results in Dom34/Hbs1‐independent endonucleolytic cleavage of mRNA, and this is stimulated by RACK1. We propose that RACK1 stimulates the translation arrest that is induced by basic amino‐acid sequences that leads to endonucleolytic cleavage of the mRNA, as well as to co‐translational protein degradation.
The receptor for activated C kinase (RACK1) participates in nascent peptide sequence‐dependent translation arrest and stimulates the endonucleolytic cleavage of translationally arrested mRNA. |
| doi_str_mv | 10.1038/embor.2010.169 |
| format | Article |
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The receptor for activated C kinase (RACK1) participates in nascent peptide sequence‐dependent translation arrest and stimulates the endonucleolytic cleavage of translationally arrested mRNA.</description><identifier>ISSN: 1469-221X</identifier><identifier>EISSN: 1469-3178</identifier><identifier>DOI: 10.1038/embor.2010.169</identifier><identifier>PMID: 21072063</identifier><identifier>CODEN: ERMEAX</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>Adaptor Proteins, Signal Transducing - chemistry ; Adaptor Proteins, Signal Transducing - genetics ; Adaptor Proteins, Signal Transducing - metabolism ; Amino Acid Sequence ; Base Sequence ; Biodegradation ; EMBO31 ; EMBO36 ; endonucleolytic cleavage ; Gene expression ; Gene Expression Regulation, Fungal ; GTP-Binding Proteins - chemistry ; GTP-Binding Proteins - genetics ; GTP-Binding Proteins - metabolism ; Kinases ; Molecular biology ; Molecular Sequence Data ; mRNA quality control ; nascent peptide ; Peptides - metabolism ; Polypeptides ; Protein Binding ; Protein Biosynthesis ; Quality control ; RACK1 ; Ribonucleic acid ; Ribosome Subunits - metabolism ; RNA ; RNA, Messenger - genetics ; RNA, Messenger - metabolism ; Saccharomyces cerevisiae - cytology ; Saccharomyces cerevisiae - genetics ; Saccharomyces cerevisiae - metabolism ; Saccharomyces cerevisiae Proteins - chemistry ; Saccharomyces cerevisiae Proteins - genetics ; Saccharomyces cerevisiae Proteins - metabolism ; Scientific Report ; Scientific Reports ; translation arrest</subject><ispartof>EMBO reports, 2010-12, Vol.11 (12), p.956-961</ispartof><rights>European Molecular Biology Organization 2010</rights><rights>Copyright © 2010 European Molecular Biology Organization</rights><rights>Copyright Nature Publishing Group Dec 2010</rights><rights>Copyright © 2010, European Molecular Biology Organization 2010 European Molecular Biology Organization</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c6799-151b77fc24606697c755d20a62c5a49f8379ee706eb2f046b67d4eba5ee330e13</citedby><cites>FETCH-LOGICAL-c6799-151b77fc24606697c755d20a62c5a49f8379ee706eb2f046b67d4eba5ee330e13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2999862/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2999862/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,1417,1433,27924,27925,45574,45575,46409,46833,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21072063$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kuroha, Kazushige</creatorcontrib><creatorcontrib>Akamatsu, Mayuko</creatorcontrib><creatorcontrib>Dimitrova, Lyudmila</creatorcontrib><creatorcontrib>Ito, Takehiko</creatorcontrib><creatorcontrib>Kato, Yuki</creatorcontrib><creatorcontrib>Shirahige, Katsuhiko</creatorcontrib><creatorcontrib>Inada, Toshifumi</creatorcontrib><title>Receptor for activated C kinase 1 stimulates nascent polypeptide-dependent translation arrest</title><title>EMBO reports</title><addtitle>EMBO Rep</addtitle><addtitle>EMBO Rep</addtitle><description>Nascent peptide‐dependent translation arrest is crucial for the quality control of eukaryotic gene expression. Here we show that the receptor for activated C kinase 1 (RACK1) participates in nascent peptide‐dependent translation arrest, and that its binding to the 40S subunit is crucial for this. Translation arrest by a nascent peptide results in Dom34/Hbs1‐independent endonucleolytic cleavage of mRNA, and this is stimulated by RACK1. We propose that RACK1 stimulates the translation arrest that is induced by basic amino‐acid sequences that leads to endonucleolytic cleavage of the mRNA, as well as to co‐translational protein degradation.
The receptor for activated C kinase (RACK1) participates in nascent peptide sequence‐dependent translation arrest and stimulates the endonucleolytic cleavage of translationally arrested mRNA.</description><subject>Adaptor Proteins, Signal Transducing - chemistry</subject><subject>Adaptor Proteins, Signal Transducing - genetics</subject><subject>Adaptor Proteins, Signal Transducing - metabolism</subject><subject>Amino Acid Sequence</subject><subject>Base Sequence</subject><subject>Biodegradation</subject><subject>EMBO31</subject><subject>EMBO36</subject><subject>endonucleolytic cleavage</subject><subject>Gene expression</subject><subject>Gene Expression Regulation, Fungal</subject><subject>GTP-Binding Proteins - chemistry</subject><subject>GTP-Binding Proteins - genetics</subject><subject>GTP-Binding Proteins - metabolism</subject><subject>Kinases</subject><subject>Molecular biology</subject><subject>Molecular Sequence Data</subject><subject>mRNA quality control</subject><subject>nascent peptide</subject><subject>Peptides - metabolism</subject><subject>Polypeptides</subject><subject>Protein Binding</subject><subject>Protein Biosynthesis</subject><subject>Quality control</subject><subject>RACK1</subject><subject>Ribonucleic acid</subject><subject>Ribosome Subunits - metabolism</subject><subject>RNA</subject><subject>RNA, Messenger - genetics</subject><subject>RNA, Messenger - metabolism</subject><subject>Saccharomyces cerevisiae - cytology</subject><subject>Saccharomyces cerevisiae - genetics</subject><subject>Saccharomyces cerevisiae - metabolism</subject><subject>Saccharomyces cerevisiae Proteins - chemistry</subject><subject>Saccharomyces cerevisiae Proteins - genetics</subject><subject>Saccharomyces cerevisiae Proteins - metabolism</subject><subject>Scientific Report</subject><subject>Scientific Reports</subject><subject>translation arrest</subject><issn>1469-221X</issn><issn>1469-3178</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkUtv1DAUhSMEog_YskQRG1aZ-pH4sUGi0yeaglSBYIMsJ7kpbhM72EnL_HucZpgCEmJh2b7-7vG5OknyAqMFRlQcQFc6vyBoujP5KNnFOZMZxVw83pwJwV92kr0QrhFCheTiabJDMOIEMbqbfL2ECvrB-bSJS1eDudUD1OkyvTFWB0hxGgbTjW2shjRWKrBD2rt23cc2U0NWQw-2nqqD1zZE0Dibau8hDM-SJ41uAzzf7PvJp5Pjj8uzbPXh9Hz5dpVVjEuZ4QKXnDcVyRliTPKKF0VNkGakKnQuG0G5BOCIQUkalLOS8TqHUhcAlCLAdD95M-v2Y9lBPXn0ulW9N532a-W0UX--WPNNXblbRaSUgpEo8Hoj4N33MTpXnYmjtq224MagBCaYUlHISL76i7x2o7dxuggVmDIsaIQWM1R5F4KHZmsFIzXlpu5zU1NuKuYWG17-PsAW_xVUBPgM3JkW1v-RU8cXh5fTZZY-mDtDbLJX4B8M_9PMZkSrh9HD9rN77EE2myETBvixZbS_UYxTXqjP70_VkViii3crrgT9CXr30Zw</recordid><startdate>201012</startdate><enddate>201012</enddate><creator>Kuroha, Kazushige</creator><creator>Akamatsu, Mayuko</creator><creator>Dimitrova, Lyudmila</creator><creator>Ito, Takehiko</creator><creator>Kato, Yuki</creator><creator>Shirahige, Katsuhiko</creator><creator>Inada, Toshifumi</creator><general>John Wiley & Sons, Ltd</general><general>Nature Publishing Group UK</general><general>Blackwell Publishing Ltd</general><general>Nature Publishing Group</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7T5</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7N</scope><scope>M7P</scope><scope>MBDVC</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201012</creationdate><title>Receptor for activated C kinase 1 stimulates nascent polypeptide-dependent translation arrest</title><author>Kuroha, Kazushige ; Akamatsu, Mayuko ; Dimitrova, Lyudmila ; Ito, Takehiko ; Kato, Yuki ; Shirahige, Katsuhiko ; Inada, Toshifumi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c6799-151b77fc24606697c755d20a62c5a49f8379ee706eb2f046b67d4eba5ee330e13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adaptor Proteins, Signal Transducing - 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Here we show that the receptor for activated C kinase 1 (RACK1) participates in nascent peptide‐dependent translation arrest, and that its binding to the 40S subunit is crucial for this. Translation arrest by a nascent peptide results in Dom34/Hbs1‐independent endonucleolytic cleavage of mRNA, and this is stimulated by RACK1. We propose that RACK1 stimulates the translation arrest that is induced by basic amino‐acid sequences that leads to endonucleolytic cleavage of the mRNA, as well as to co‐translational protein degradation.
The receptor for activated C kinase (RACK1) participates in nascent peptide sequence‐dependent translation arrest and stimulates the endonucleolytic cleavage of translationally arrested mRNA.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>21072063</pmid><doi>10.1038/embor.2010.169</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adaptor Proteins, Signal Transducing - chemistry Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Amino Acid Sequence Base Sequence Biodegradation EMBO31 EMBO36 endonucleolytic cleavage Gene expression Gene Expression Regulation, Fungal GTP-Binding Proteins - chemistry GTP-Binding Proteins - genetics GTP-Binding Proteins - metabolism Kinases Molecular biology Molecular Sequence Data mRNA quality control nascent peptide Peptides - metabolism Polypeptides Protein Binding Protein Biosynthesis Quality control RACK1 Ribonucleic acid Ribosome Subunits - metabolism RNA RNA, Messenger - genetics RNA, Messenger - metabolism Saccharomyces cerevisiae - cytology Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins - chemistry Saccharomyces cerevisiae Proteins - genetics Saccharomyces cerevisiae Proteins - metabolism Scientific Report Scientific Reports translation arrest |
| title | Receptor for activated C kinase 1 stimulates nascent polypeptide-dependent translation arrest |
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