Dok1 and Dok2 play opposing roles in CD200R signaling1

The CD200 receptor (CD200R) negatively regulates myeloid cells by interacting with its widely expressed ligand CD200. CD200R signals through a unique inhibitory pathway involving a direct interaction with the adaptor protein Dok2 and the subsequent recruitment and activation of RasGAP. Ligand engage...

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Veröffentlicht in:	The Journal of immunology (1950) 2010-11, Vol.185 (12), p.7216-7222
Hauptverfasser:	Mihrshahi, Robin, Brown, Marion H.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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