Effect of bisphosphonates on vascular calcification and bone metabolism in experimental renal failure

Although it is known that bisphosphonates prevent medial vascular calcification in vivo, their mechanism of action remains unknown and, in particular, whether they act directly on the blood vessels or indirectly through inhibition of bone resorption. To determine this, we studied the effects of two...

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Veröffentlicht in:	Kidney international 2009-03, Vol.75 (6), p.617-625
Hauptverfasser:	Lomashvili, Koba A., Monier-Faugere, Marie-Claude, Wang, Xiaonan, Malluche, Hartmut H., O'Neill, W. Charles
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aortic Diseases - pathology Biological and medical sciences Bone and Bones - metabolism bone formation bone histomorphometry Bone Resorption Calcification, Physiologic - drug effects Calcinosis - prevention & control Diphosphonates - adverse effects Diphosphonates - pharmacology Diphosphonates - therapeutic use Etidronic Acid - adverse effects Etidronic Acid - therapeutic use Medical sciences Nephrology. Urinary tract diseases Nephropathies. Renovascular diseases. Renal failure pyrophosphate rat aorta Rats Renal failure Uremia - complications uremic osteodystrophy
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