Biologically Active Fragment of a Human tRNA Synthetase Inhibits Fluid Shear Stress-Activated Responses of Endothelial Cells

Human tryptophanyl-tRNA synthetase (TrpRS) is active in translation and angiogenesis. In particular, an N-terminally truncated fragment, T2-TrpRS, that is closely related to a natural splice variant is a potent antagonist of vascular endothelial growth factor-induced angiogenesis in several in vivo...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2003-12, Vol.100 (25), p.14903-14907
Hauptverfasser:	Tzima, E., Reader, J. S., Irani-Tehrani, M., Ewalt, K. L., Schwartz, M. A., Schimmel, P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins Amino Acyl-tRNA Synthetases - metabolism Angiogenesis Animals Biological Sciences Blood vessels Cattle Cellular biology Cytoskeleton - metabolism Endothelial cells Endothelial growth factors Endothelium, Vascular - metabolism Gene expression regulation Genetic Vectors Humans Luciferases - metabolism Microscopy, Fluorescence Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 Mitogen-Activated Protein Kinases - metabolism Neovascularization, Pathologic Nitric Oxide Synthase - metabolism Phosphorylation Physiological regulation Protein Structure, Tertiary Protein-Serine-Threonine Kinases Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-akt Ribonucleic acid RNA Shear stress Signal Transduction Stress fibers Stress, Mechanical Temperature Time Factors Transcription, Genetic
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