The influence of antiviral therapy on psychiatric symptoms among patients with hepatitis C and schizophrenia
Antiviral therapy for chronic infection with HCV is associated with significant neuropsychiatric side effects. Research indicates that patients with mental illness are less likely to receive antiviral therapy, despite limited data regarding the influence of antiviral therapy on psychiatric symptoms...
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| Veröffentlicht in: | Antiviral therapy 2010, Vol.15 (1), p.111-119 |
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| creator | HUCKANS, Marilyn MITCHELL, Alex PAVAWALLA, Shital MORASCO, Benjamin J RUIMY, Samantha LOFTIS, Jennifer M RIFAI, Muhamad A HAUSER, Peter |
| description | Antiviral therapy for chronic infection with HCV is associated with significant neuropsychiatric side effects. Research indicates that patients with mental illness are less likely to receive antiviral therapy, despite limited data regarding the influence of antiviral therapy on psychiatric symptoms in patients with specific psychiatric disorders. The aim of this study was to determine whether antiviral therapy is associated with higher rates of psychiatric symptoms in patients with schizophrenia (SCHZ).
A regional Veterans Healthcare Administration database was used to identify veterans meeting criteria for this retrospective chart review. Patients confirmed to have SCHZ and to have received antiviral therapy for HCV between 1998 and 2006 (n=30) were compared with a control group of demographically matched (age, race and gender) patients with SCHZ who did not receive antiviral therapy (n=30). Clinicians blinded to antiviral therapy status used chart notes to evaluate whether patients exhibited prominent symptoms of SCHZ, depression or mania during a 6 month pre-treatment period, the treatment period and a 6 month post-treatment period (or during equivalent periods for the control group).
Groups did not significantly differ in rates of symptoms of SCHZ, depression or mania during any study period. During the treatment period, groups did not significantly differ in rates of emergency room visits or inpatient hospitalizations.
Our retrospective chart review suggests that patients with SCHZ experience similar rates of psychiatric symptoms on and off antiviral therapy. Despite limitations and constraints of the methods, our data suggest that SCHZ is not a contraindication to antiviral therapy for HCV. |
| doi_str_mv | 10.3851/IMP1493 |
| format | Article |
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A regional Veterans Healthcare Administration database was used to identify veterans meeting criteria for this retrospective chart review. Patients confirmed to have SCHZ and to have received antiviral therapy for HCV between 1998 and 2006 (n=30) were compared with a control group of demographically matched (age, race and gender) patients with SCHZ who did not receive antiviral therapy (n=30). Clinicians blinded to antiviral therapy status used chart notes to evaluate whether patients exhibited prominent symptoms of SCHZ, depression or mania during a 6 month pre-treatment period, the treatment period and a 6 month post-treatment period (or during equivalent periods for the control group).
Groups did not significantly differ in rates of symptoms of SCHZ, depression or mania during any study period. During the treatment period, groups did not significantly differ in rates of emergency room visits or inpatient hospitalizations.
Our retrospective chart review suggests that patients with SCHZ experience similar rates of psychiatric symptoms on and off antiviral therapy. Despite limitations and constraints of the methods, our data suggest that SCHZ is not a contraindication to antiviral therapy for HCV.</description><identifier>ISSN: 1359-6535</identifier><identifier>EISSN: 2040-2058</identifier><identifier>DOI: 10.3851/IMP1493</identifier><identifier>PMID: 20167997</identifier><language>eng</language><publisher>London: International Medical Press</publisher><subject>Adult ; Adult and adolescent clinical studies ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Antiviral agents ; Antiviral Agents - adverse effects ; Biological and medical sciences ; Bipolar Disorder - etiology ; Bipolar Disorder - physiopathology ; Depression - etiology ; Depression - physiopathology ; Female ; Hepacivirus - drug effects ; Hepatitis C virus ; Hepatitis C, Chronic - complications ; Hepatitis C, Chronic - drug therapy ; Hepatitis C, Chronic - virology ; Hospitalization ; Human viral diseases ; Humans ; Infectious diseases ; Male ; Medical sciences ; Middle Aged ; Outcome Assessment (Health Care) ; Pharmacology. Drug treatments ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Psychoses ; Retrospective Studies ; Schizophrenia ; Schizophrenia - complications ; Schizophrenia - physiopathology ; Treatment Refusal ; Viral diseases ; Viral hepatitis</subject><ispartof>Antiviral therapy, 2010, Vol.15 (1), p.111-119</ispartof><rights>2015 INIST-CNRS</rights><rights>2010 International Medical Press 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c430t-9a4954ffba92e0b003113e7969cdd6149dd09008497eacb9894109d5ccf1e2053</citedby><cites>FETCH-LOGICAL-c430t-9a4954ffba92e0b003113e7969cdd6149dd09008497eacb9894109d5ccf1e2053</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,315,782,786,887,4026,27930,27931,27932</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22515579$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20167997$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>HUCKANS, Marilyn</creatorcontrib><creatorcontrib>MITCHELL, Alex</creatorcontrib><creatorcontrib>PAVAWALLA, Shital</creatorcontrib><creatorcontrib>MORASCO, Benjamin J</creatorcontrib><creatorcontrib>RUIMY, Samantha</creatorcontrib><creatorcontrib>LOFTIS, Jennifer M</creatorcontrib><creatorcontrib>RIFAI, Muhamad A</creatorcontrib><creatorcontrib>HAUSER, Peter</creatorcontrib><title>The influence of antiviral therapy on psychiatric symptoms among patients with hepatitis C and schizophrenia</title><title>Antiviral therapy</title><addtitle>Antivir Ther</addtitle><description>Antiviral therapy for chronic infection with HCV is associated with significant neuropsychiatric side effects. Research indicates that patients with mental illness are less likely to receive antiviral therapy, despite limited data regarding the influence of antiviral therapy on psychiatric symptoms in patients with specific psychiatric disorders. The aim of this study was to determine whether antiviral therapy is associated with higher rates of psychiatric symptoms in patients with schizophrenia (SCHZ).
A regional Veterans Healthcare Administration database was used to identify veterans meeting criteria for this retrospective chart review. Patients confirmed to have SCHZ and to have received antiviral therapy for HCV between 1998 and 2006 (n=30) were compared with a control group of demographically matched (age, race and gender) patients with SCHZ who did not receive antiviral therapy (n=30). Clinicians blinded to antiviral therapy status used chart notes to evaluate whether patients exhibited prominent symptoms of SCHZ, depression or mania during a 6 month pre-treatment period, the treatment period and a 6 month post-treatment period (or during equivalent periods for the control group).
Groups did not significantly differ in rates of symptoms of SCHZ, depression or mania during any study period. During the treatment period, groups did not significantly differ in rates of emergency room visits or inpatient hospitalizations.
Our retrospective chart review suggests that patients with SCHZ experience similar rates of psychiatric symptoms on and off antiviral therapy. Despite limitations and constraints of the methods, our data suggest that SCHZ is not a contraindication to antiviral therapy for HCV.</description><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Antiviral agents</subject><subject>Antiviral Agents - adverse effects</subject><subject>Biological and medical sciences</subject><subject>Bipolar Disorder - etiology</subject><subject>Bipolar Disorder - physiopathology</subject><subject>Depression - etiology</subject><subject>Depression - physiopathology</subject><subject>Female</subject><subject>Hepacivirus - drug effects</subject><subject>Hepatitis C virus</subject><subject>Hepatitis C, Chronic - complications</subject><subject>Hepatitis C, Chronic - drug therapy</subject><subject>Hepatitis C, Chronic - virology</subject><subject>Hospitalization</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Outcome Assessment (Health Care)</subject><subject>Pharmacology. Drug treatments</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Psychoses</subject><subject>Retrospective Studies</subject><subject>Schizophrenia</subject><subject>Schizophrenia - complications</subject><subject>Schizophrenia - physiopathology</subject><subject>Treatment Refusal</subject><subject>Viral diseases</subject><subject>Viral hepatitis</subject><issn>1359-6535</issn><issn>2040-2058</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkU9v1DAQxS0EoktBfAPkC-IUGMf2JnNBQiv-VCqCQzlbs47TGCV2sL1Fy6fHFUsLp9FofvNmnh5jzwW8lr0Wby4-fxUK5QO2aUFB04LuH7KNkBqbrZb6jD3J-TtA2yPAY3bWgth2iN2GzVeT4z6M88EF63gcOYXib3yimZfJJVqPPAa-5qOdPJXkLc_HZS1xyZyWGK75SsW7UDL_6cvEJ3fbF5_5rioNPNe1X3GdkguenrJHI83ZPTvVc_btw_ur3afm8svHi927y8YqCaVBUqjVOO4JWwd7ACmEdB1u0Q7DtvocBqg-eoWdI7vHHpUAHLS1o3DVujxnb__orof94gZb36t-zJr8QuloInnz_yT4yVzHG9Mi9kpiFXh1Ekjxx8HlYhafrZtnCi4esum00lJBJ-5Jm2LOyY13VwSY22jMKZpKvvj3qTvubxYVeHkCKFuax0TB-nzPtVpo3aH8DcEYmLs</recordid><startdate>2010</startdate><enddate>2010</enddate><creator>HUCKANS, Marilyn</creator><creator>MITCHELL, Alex</creator><creator>PAVAWALLA, Shital</creator><creator>MORASCO, Benjamin J</creator><creator>RUIMY, Samantha</creator><creator>LOFTIS, Jennifer M</creator><creator>RIFAI, Muhamad A</creator><creator>HAUSER, Peter</creator><general>International Medical Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T7</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>5PM</scope></search><sort><creationdate>2010</creationdate><title>The influence of antiviral therapy on psychiatric symptoms among patients with hepatitis C and schizophrenia</title><author>HUCKANS, Marilyn ; MITCHELL, Alex ; PAVAWALLA, Shital ; MORASCO, Benjamin J ; RUIMY, Samantha ; LOFTIS, Jennifer M ; RIFAI, Muhamad A ; HAUSER, Peter</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c430t-9a4954ffba92e0b003113e7969cdd6149dd09008497eacb9894109d5ccf1e2053</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adult</topic><topic>Adult and adolescent clinical studies</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Antiviral agents</topic><topic>Antiviral Agents - adverse effects</topic><topic>Biological and medical sciences</topic><topic>Bipolar Disorder - etiology</topic><topic>Bipolar Disorder - physiopathology</topic><topic>Depression - etiology</topic><topic>Depression - physiopathology</topic><topic>Female</topic><topic>Hepacivirus - drug effects</topic><topic>Hepatitis C virus</topic><topic>Hepatitis C, Chronic - complications</topic><topic>Hepatitis C, Chronic - drug therapy</topic><topic>Hepatitis C, Chronic - virology</topic><topic>Hospitalization</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Outcome Assessment (Health Care)</topic><topic>Pharmacology. Drug treatments</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Psychoses</topic><topic>Retrospective Studies</topic><topic>Schizophrenia</topic><topic>Schizophrenia - complications</topic><topic>Schizophrenia - physiopathology</topic><topic>Treatment Refusal</topic><topic>Viral diseases</topic><topic>Viral hepatitis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>HUCKANS, Marilyn</creatorcontrib><creatorcontrib>MITCHELL, Alex</creatorcontrib><creatorcontrib>PAVAWALLA, Shital</creatorcontrib><creatorcontrib>MORASCO, Benjamin J</creatorcontrib><creatorcontrib>RUIMY, Samantha</creatorcontrib><creatorcontrib>LOFTIS, Jennifer M</creatorcontrib><creatorcontrib>RIFAI, Muhamad A</creatorcontrib><creatorcontrib>HAUSER, Peter</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Antiviral therapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>HUCKANS, Marilyn</au><au>MITCHELL, Alex</au><au>PAVAWALLA, Shital</au><au>MORASCO, Benjamin J</au><au>RUIMY, Samantha</au><au>LOFTIS, Jennifer M</au><au>RIFAI, Muhamad A</au><au>HAUSER, Peter</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The influence of antiviral therapy on psychiatric symptoms among patients with hepatitis C and schizophrenia</atitle><jtitle>Antiviral therapy</jtitle><addtitle>Antivir Ther</addtitle><date>2010</date><risdate>2010</risdate><volume>15</volume><issue>1</issue><spage>111</spage><epage>119</epage><pages>111-119</pages><issn>1359-6535</issn><eissn>2040-2058</eissn><abstract>Antiviral therapy for chronic infection with HCV is associated with significant neuropsychiatric side effects. Research indicates that patients with mental illness are less likely to receive antiviral therapy, despite limited data regarding the influence of antiviral therapy on psychiatric symptoms in patients with specific psychiatric disorders. The aim of this study was to determine whether antiviral therapy is associated with higher rates of psychiatric symptoms in patients with schizophrenia (SCHZ).
A regional Veterans Healthcare Administration database was used to identify veterans meeting criteria for this retrospective chart review. Patients confirmed to have SCHZ and to have received antiviral therapy for HCV between 1998 and 2006 (n=30) were compared with a control group of demographically matched (age, race and gender) patients with SCHZ who did not receive antiviral therapy (n=30). Clinicians blinded to antiviral therapy status used chart notes to evaluate whether patients exhibited prominent symptoms of SCHZ, depression or mania during a 6 month pre-treatment period, the treatment period and a 6 month post-treatment period (or during equivalent periods for the control group).
Groups did not significantly differ in rates of symptoms of SCHZ, depression or mania during any study period. During the treatment period, groups did not significantly differ in rates of emergency room visits or inpatient hospitalizations.
Our retrospective chart review suggests that patients with SCHZ experience similar rates of psychiatric symptoms on and off antiviral therapy. Despite limitations and constraints of the methods, our data suggest that SCHZ is not a contraindication to antiviral therapy for HCV.</abstract><cop>London</cop><pub>International Medical Press</pub><pmid>20167997</pmid><doi>10.3851/IMP1493</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Adult and adolescent clinical studies Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Antiviral Agents - adverse effects Biological and medical sciences Bipolar Disorder - etiology Bipolar Disorder - physiopathology Depression - etiology Depression - physiopathology Female Hepacivirus - drug effects Hepatitis C virus Hepatitis C, Chronic - complications Hepatitis C, Chronic - drug therapy Hepatitis C, Chronic - virology Hospitalization Human viral diseases Humans Infectious diseases Male Medical sciences Middle Aged Outcome Assessment (Health Care) Pharmacology. Drug treatments Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychoses Retrospective Studies Schizophrenia Schizophrenia - complications Schizophrenia - physiopathology Treatment Refusal Viral diseases Viral hepatitis |
| title | The influence of antiviral therapy on psychiatric symptoms among patients with hepatitis C and schizophrenia |
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