LRP5 sequence and polymorphisms in the baboon
Background LRP5 is known to have an important relationship with bone density and a variety of other biological processes. Mapping to human chromosome 11q13.2, LRP5 shows considerable evolutionary conservation. Orthologs of this gene exist in many species, although comparison of human LRP5 with othe...
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| Veröffentlicht in: | Journal of medical primatology 2009-04, Vol.38 (2), p.97-106 |
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| container_title | Journal of medical primatology |
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| creator | Doubleday, Alison F. Kaestle, Frederika A. Cox, Laura A. Birnbaum, Shifra Mahaney, Michael C. Havill, Lorena M. |
| description | Background LRP5 is known to have an important relationship with bone density and a variety of other biological processes. Mapping to human chromosome 11q13.2, LRP5 shows considerable evolutionary conservation. Orthologs of this gene exist in many species, although comparison of human LRP5 with other non‐human primates has not been performed until now.
Methods We reported the complementary DNA (cDNA) sequence and deduced amino acid sequence for baboon LRP5, and compared the baboon and human sequences. cDNA sequences for 21 baboons were examined to identify single‐nucleotide polymorphisms (SNPs).
Results Sequences of coding regions in human and baboon LRP5 showed 97– 99% homology. Twenty‐five SNPs were identified in the coding region of baboon LRP5.
Conclusion The observed degree of coding sequence homology in LRP5 led us to expect that the baboon may serve as a useful model for future research into the role(s) of this gene in primate metabolic diseases. |
| doi_str_mv | 10.1111/j.1600-0684.2008.00317.x |
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Methods We reported the complementary DNA (cDNA) sequence and deduced amino acid sequence for baboon LRP5, and compared the baboon and human sequences. cDNA sequences for 21 baboons were examined to identify single‐nucleotide polymorphisms (SNPs).
Results Sequences of coding regions in human and baboon LRP5 showed 97– 99% homology. Twenty‐five SNPs were identified in the coding region of baboon LRP5.
Conclusion The observed degree of coding sequence homology in LRP5 led us to expect that the baboon may serve as a useful model for future research into the role(s) of this gene in primate metabolic diseases.</description><identifier>ISSN: 0047-2565</identifier><identifier>EISSN: 1600-0684</identifier><identifier>DOI: 10.1111/j.1600-0684.2008.00317.x</identifier><identifier>PMID: 19367734</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Amino Acid Sequence ; Animals ; Bone Density ; Female ; Humans ; LDL-Receptor Related Proteins - chemistry ; LDL-Receptor Related Proteins - genetics ; Low Density Lipoprotein Receptor-Related Protein-5 ; Male ; Molecular Sequence Data ; non-human primate model ; Papio ; Papio anubis - genetics ; Papio cynocephalus - genetics ; Polymorphism, Single Nucleotide ; primate genetics ; Primates ; Sequence Alignment ; Sequence Analysis, DNA ; Sequence Homology, Amino Acid ; Wnt-signaling pathway</subject><ispartof>Journal of medical primatology, 2009-04, Vol.38 (2), p.97-106</ispartof><rights>2008 The Authors. Journal compilation © 2008 Blackwell Munksgaard</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4907-b28a3933e8952578ec5b013b9e851abf3ab44c72733e9209462733f51fdf370c3</citedby><cites>FETCH-LOGICAL-c4907-b28a3933e8952578ec5b013b9e851abf3ab44c72733e9209462733f51fdf370c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1600-0684.2008.00317.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1600-0684.2008.00317.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,776,780,881,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19367734$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Doubleday, Alison F.</creatorcontrib><creatorcontrib>Kaestle, Frederika A.</creatorcontrib><creatorcontrib>Cox, Laura A.</creatorcontrib><creatorcontrib>Birnbaum, Shifra</creatorcontrib><creatorcontrib>Mahaney, Michael C.</creatorcontrib><creatorcontrib>Havill, Lorena M.</creatorcontrib><title>LRP5 sequence and polymorphisms in the baboon</title><title>Journal of medical primatology</title><addtitle>J Med Primatol</addtitle><description>Background LRP5 is known to have an important relationship with bone density and a variety of other biological processes. Mapping to human chromosome 11q13.2, LRP5 shows considerable evolutionary conservation. Orthologs of this gene exist in many species, although comparison of human LRP5 with other non‐human primates has not been performed until now.
Methods We reported the complementary DNA (cDNA) sequence and deduced amino acid sequence for baboon LRP5, and compared the baboon and human sequences. cDNA sequences for 21 baboons were examined to identify single‐nucleotide polymorphisms (SNPs).
Results Sequences of coding regions in human and baboon LRP5 showed 97– 99% homology. Twenty‐five SNPs were identified in the coding region of baboon LRP5.
Conclusion The observed degree of coding sequence homology in LRP5 led us to expect that the baboon may serve as a useful model for future research into the role(s) of this gene in primate metabolic diseases.</description><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Bone Density</subject><subject>Female</subject><subject>Humans</subject><subject>LDL-Receptor Related Proteins - chemistry</subject><subject>LDL-Receptor Related Proteins - genetics</subject><subject>Low Density Lipoprotein Receptor-Related Protein-5</subject><subject>Male</subject><subject>Molecular Sequence Data</subject><subject>non-human primate model</subject><subject>Papio</subject><subject>Papio anubis - genetics</subject><subject>Papio cynocephalus - genetics</subject><subject>Polymorphism, Single Nucleotide</subject><subject>primate genetics</subject><subject>Primates</subject><subject>Sequence Alignment</subject><subject>Sequence Analysis, DNA</subject><subject>Sequence Homology, Amino Acid</subject><subject>Wnt-signaling pathway</subject><issn>0047-2565</issn><issn>1600-0684</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkV9v0zAUxS3ERLvBV0B54i3Z9b_YlhASqqDb1G0VAvF45aQOTUniEres_fZz1qrA0_CLr3R_59j3HkISChmN53KV0RwghVyLjAHoDIBTle1ekPGp8ZKMAYRKmczliJyHsIJICSNekRE1PFeKizFJZ1_mMgnu19Z1pUtst0jWvtm3vl8v69CGpO6SzdIlhS28716Ts8o2wb053hfk2-dPXydX6ex-ej35OEtLYUClBdOWG86dNpJJpV0pC6C8ME5LaouK20KIUjEVEcPAiHwoK0mrRcUVlPyCfDj4rrdF6xal6za9bXDd163t9-htjf92unqJP_xvZMZopvNo8O5o0Ps4WthgW4fSNY3tnN8GzBWlmsZHnwMZKMG5ohHUB7DsfQi9q06_oYBDKLjCYfc47B6HUPApFNxF6du_p_kjPKYQgfcH4KFu3P6_jfHmdh6LKE8P8jps3O4kt_3POCdXEr_fTfFKamB6NsU5fwRA06g1</recordid><startdate>200904</startdate><enddate>200904</enddate><creator>Doubleday, Alison F.</creator><creator>Kaestle, Frederika A.</creator><creator>Cox, Laura A.</creator><creator>Birnbaum, Shifra</creator><creator>Mahaney, Michael C.</creator><creator>Havill, Lorena M.</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>200904</creationdate><title>LRP5 sequence and polymorphisms in the baboon</title><author>Doubleday, Alison F. ; Kaestle, Frederika A. ; Cox, Laura A. ; Birnbaum, Shifra ; Mahaney, Michael C. ; Havill, Lorena M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4907-b28a3933e8952578ec5b013b9e851abf3ab44c72733e9209462733f51fdf370c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Amino Acid Sequence</topic><topic>Animals</topic><topic>Bone Density</topic><topic>Female</topic><topic>Humans</topic><topic>LDL-Receptor Related Proteins - chemistry</topic><topic>LDL-Receptor Related Proteins - genetics</topic><topic>Low Density Lipoprotein Receptor-Related Protein-5</topic><topic>Male</topic><topic>Molecular Sequence Data</topic><topic>non-human primate model</topic><topic>Papio</topic><topic>Papio anubis - genetics</topic><topic>Papio cynocephalus - genetics</topic><topic>Polymorphism, Single Nucleotide</topic><topic>primate genetics</topic><topic>Primates</topic><topic>Sequence Alignment</topic><topic>Sequence Analysis, DNA</topic><topic>Sequence Homology, Amino Acid</topic><topic>Wnt-signaling pathway</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Doubleday, Alison F.</creatorcontrib><creatorcontrib>Kaestle, Frederika A.</creatorcontrib><creatorcontrib>Cox, Laura A.</creatorcontrib><creatorcontrib>Birnbaum, Shifra</creatorcontrib><creatorcontrib>Mahaney, Michael C.</creatorcontrib><creatorcontrib>Havill, Lorena M.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of medical primatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Doubleday, Alison F.</au><au>Kaestle, Frederika A.</au><au>Cox, Laura A.</au><au>Birnbaum, Shifra</au><au>Mahaney, Michael C.</au><au>Havill, Lorena M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>LRP5 sequence and polymorphisms in the baboon</atitle><jtitle>Journal of medical primatology</jtitle><addtitle>J Med Primatol</addtitle><date>2009-04</date><risdate>2009</risdate><volume>38</volume><issue>2</issue><spage>97</spage><epage>106</epage><pages>97-106</pages><issn>0047-2565</issn><eissn>1600-0684</eissn><abstract>Background LRP5 is known to have an important relationship with bone density and a variety of other biological processes. Mapping to human chromosome 11q13.2, LRP5 shows considerable evolutionary conservation. Orthologs of this gene exist in many species, although comparison of human LRP5 with other non‐human primates has not been performed until now.
Methods We reported the complementary DNA (cDNA) sequence and deduced amino acid sequence for baboon LRP5, and compared the baboon and human sequences. cDNA sequences for 21 baboons were examined to identify single‐nucleotide polymorphisms (SNPs).
Results Sequences of coding regions in human and baboon LRP5 showed 97– 99% homology. Twenty‐five SNPs were identified in the coding region of baboon LRP5.
Conclusion The observed degree of coding sequence homology in LRP5 led us to expect that the baboon may serve as a useful model for future research into the role(s) of this gene in primate metabolic diseases.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>19367734</pmid><doi>10.1111/j.1600-0684.2008.00317.x</doi><tpages>10</tpages></addata></record> |
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| source | Wiley Online Library - AutoHoldings Journals; MEDLINE |
| subjects | Amino Acid Sequence Animals Bone Density Female Humans LDL-Receptor Related Proteins - chemistry LDL-Receptor Related Proteins - genetics Low Density Lipoprotein Receptor-Related Protein-5 Male Molecular Sequence Data non-human primate model Papio Papio anubis - genetics Papio cynocephalus - genetics Polymorphism, Single Nucleotide primate genetics Primates Sequence Alignment Sequence Analysis, DNA Sequence Homology, Amino Acid Wnt-signaling pathway |
| title | LRP5 sequence and polymorphisms in the baboon |
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