Antibodies as a model system for comparative model refinement

Predicting the conformations of loops is a critical aspect of protein comparative (homology) modeling. Despite considerable advances in developing loop prediction algorithms, refining loops in homology models remains challenging. In this work, we use antibodies as a model system to investigate strat...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Proteins, structure, function, and bioinformatics structure, function, and bioinformatics, 2010-08, Vol.78 (11), p.2490-2505
Hauptverfasser:	Sellers, Benjamin D., Nilmeier, Jerome P., Jacobson, Matthew P.
Format:	Artikel
Sprache:	eng
Schlagworte:	all-atom comparative Complementarity Determining Regions - chemistry Crystallography, X-Ray homology modeling Immunoglobulin Fragments - chemistry loop prediction Models, Molecular Models, Statistical physics-based force field Protein Conformation refinement Structural Homology, Protein
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!