Deletion of CD14 attenuates Alzheimer's disease pathology by influencing the brain's inflammatory milieu

Alzheimer's disease (AD) is characterized by the deposition of β-amyloid (Aβ)-containing plaques within the brain that is accompanied by a robust microglial-mediated inflammatory response. This inflammatory response is reliant upon engagement of innate immune signaling pathways involving the to...

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Veröffentlicht in:	The Journal of neuroscience 2010-11, Vol.30 (46), p.15369-15373
Hauptverfasser:	Reed-Geaghan, Erin G, Reed, Quillan W, Cramer, Paige E, Landreth, Gary E
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - genetics Alzheimer Disease - pathology Alzheimer Disease - prevention & control Amyloid beta-Peptides - antagonists & inhibitors Amyloid beta-Peptides - physiology Animals Brain - metabolism Brain - pathology Brief Communications Disease Models, Animal Female Gene Deletion Inflammation - genetics Inflammation - pathology Inflammation - prevention & control Inflammation Mediators - antagonists & inhibitors Inflammation Mediators - physiology Lipopolysaccharide Receptors - genetics Lipopolysaccharide Receptors - physiology Male Mice Mice, Inbred C57BL Mice, Knockout Mice, Transgenic Microglia - cytology Microglia - metabolism
Online-Zugang:	Volltext
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