MicroRNA Regulation of DNA Repair Gene Expression in Hypoxic Stress

Genetic instability is a hallmark of cancer; the hypoxic tumor microenvironment has been implicated as a cause of this phenomenon. MicroRNAs (miR) are small nonprotein coding RNAs that can regulate various cellular pathways. We report here that two miRs, miR-210 and miR-373, are up-regulated in a hy...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2009-02, Vol.69 (3), p.1221-1229
Hauptverfasser:	CROSBY, Meredith E, KULSHRESHTHA, Ritu, IVAN, Mircea, GLAZER, Peter M
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Binding Sites Biological and medical sciences Breast Neoplasms - genetics Cell Hypoxia - genetics Cell Line, Tumor DNA Repair - genetics DNA Repair Enzymes - biosynthesis DNA Repair Enzymes - genetics DNA-Binding Proteins - biosynthesis DNA-Binding Proteins - genetics Gene Expression Regulation, Neoplastic - physiology HeLa Cells Humans Hypoxia-Inducible Factor 1, alpha Subunit - biosynthesis Hypoxia-Inducible Factor 1, alpha Subunit - genetics Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Liver X Receptors Medical sciences MicroRNAs - biosynthesis MicroRNAs - genetics Orphan Nuclear Receptors Pharmacology. Drug treatments Rad52 DNA Repair and Recombination Protein - biosynthesis Rad52 DNA Repair and Recombination Protein - genetics Receptors, Cytoplasmic and Nuclear - biosynthesis Receptors, Cytoplasmic and Nuclear - genetics Tumors Up-Regulation
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