Monocytes/macrophages in kidney allograft intimal arteritis: no association with markers of humoral rejection or with inferior outcome
Background. Several studies indicate that interstitial and intracapillary monocytes/macrophages (MO) represent a significant proportion of graft-infiltrating cells in renal allografts and that their presence may unfavourably affect clinical outcome. Much less is known about the role of MO in vascula...
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| Veröffentlicht in: | Nephrology, dialysis, transplantation dialysis, transplantation, 2009-06, Vol.24 (6), p.1979-1986 |
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| container_issue | 6 |
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| container_title | Nephrology, dialysis, transplantation |
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| creator | Kozakowski, Nicolas Böhmig, Georg A. Exner, Markus Soleiman, Afschin Huttary, Nicole Nagy-Bojarszky, Katalin Ecker, Rupert C. Kikić, Željko Regele, Heinz |
| description | Background. Several studies indicate that interstitial and intracapillary monocytes/macrophages (MO) represent a significant proportion of graft-infiltrating cells in renal allografts and that their presence may unfavourably affect clinical outcome. Much less is known about the role of MO in vascular rejection of transplanted kidneys. The aim of our study was to determine the cellular composition of immune cell infiltrates in intimal arteritis and to analyse whether it is associated with features of humoral immunity and impaired graft survival. Methods. In 34 recipients with vascular rejection, we determined the proportion of intimal and interstitial MO and T-cells (expressed as ratio of CD68- and CD3-positive cells) in immunohistochemically double-labelled slides. Results. Intimal arteritis is always composed of T-cells and MO with a median CD68/CD3 ratio of 1.03. In 47% of cases, however, T-cells predominate (CD68/CD3 ratio |
| doi_str_mv | 10.1093/ndt/gfp045 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2997283</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><oup_id>10.1093/ndt/gfp045</oup_id><sourcerecordid>20664603</sourcerecordid><originalsourceid>FETCH-LOGICAL-c462t-9d75f26bf1e7b77dc61e66481edab94886059b5ff6a71e469145947b44f76b3c3</originalsourceid><addsrcrecordid>eNqFkk-PEyEYxonRuLV68QOYiYkeTMYCw59hDyZu47oma7xoNF4Iw0BLdwYqMGq_gJ9b1jZd9aAnAu-Ph_fleQB4iOBzBEWz8H1erOwWEnoLzBBhsMZNS2-DWSmiGlIoTsC9lDYQQoE5vwtOkMC4wZzOwI-3wQe9yyYtRqVj2K7VyqTK-erK9d7sKjUMYRWVzeUsu1ENlYrZRJddOq18qFRKQTuVXfDVN5fX1ajilYmpCrZaT2OI5UY0G6N_ESHuIedt0Si7MGUdRnMf3LFqSObBYZ2DD-ev3i8v6st3r98sX17WmjCca9FzajHrLDK847zXDBnGSItMrzpB2pZBKjpqLVMcGcIEIlQQ3hFiOesa3czBi73udupG02vjc2lQbmOZLO5kUE7-WfFuLVfhq8RCcNw2ReDpQSCGL5NJWY4uaTMMypswJckKhSET_wULxIpV14qP_wI3YYq-_ILEqEWMoOLVHDzbQ8WilKKxx5YRlNchkCUEch-CAj_6fcgb9OB6AZ4cAJW0GmxUXrt05DCilGEibrgwbf_9YL3nXMrm-5EsQSj_0XAqLz59lmfnDH9EZ0u5bH4CuQHaRw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>218164122</pqid></control><display><type>article</type><title>Monocytes/macrophages in kidney allograft intimal arteritis: no association with markers of humoral rejection or with inferior outcome</title><source>Oxford University Press Journals All Titles (1996-Current)</source><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><creator>Kozakowski, Nicolas ; Böhmig, Georg A. ; Exner, Markus ; Soleiman, Afschin ; Huttary, Nicole ; Nagy-Bojarszky, Katalin ; Ecker, Rupert C. ; Kikić, Željko ; Regele, Heinz</creator><creatorcontrib>Kozakowski, Nicolas ; Böhmig, Georg A. ; Exner, Markus ; Soleiman, Afschin ; Huttary, Nicole ; Nagy-Bojarszky, Katalin ; Ecker, Rupert C. ; Kikić, Željko ; Regele, Heinz</creatorcontrib><description>Background. Several studies indicate that interstitial and intracapillary monocytes/macrophages (MO) represent a significant proportion of graft-infiltrating cells in renal allografts and that their presence may unfavourably affect clinical outcome. Much less is known about the role of MO in vascular rejection of transplanted kidneys. The aim of our study was to determine the cellular composition of immune cell infiltrates in intimal arteritis and to analyse whether it is associated with features of humoral immunity and impaired graft survival. Methods. In 34 recipients with vascular rejection, we determined the proportion of intimal and interstitial MO and T-cells (expressed as ratio of CD68- and CD3-positive cells) in immunohistochemically double-labelled slides. Results. Intimal arteritis is always composed of T-cells and MO with a median CD68/CD3 ratio of 1.03. In 47% of cases, however, T-cells predominate (CD68/CD3 ratio <1). The median interstitial CD68/CD3 ratio is 0.61, with T-cells dominating in 64% of cases. There is no correlation between the cellular composition of arterial and interstitial infiltrates. The proportion of interstitial and arterial MO has no impact on graft survival, and is, in contrast to previous reports on MO in allograft glomerulitis and capillaritis, not associated with C4d staining. Conclusions. Intimal arteritis in kidney allograft rejection is composed of a mixed infiltrate of MO and T-lymphocytes. In contrast to MO in PTCitis and glomerulitis, the MO in intimal arteritis are not associated with markers of humoral immune response and there are no different allograft outcomes between MO and T-lymphocyte-dominated groups.</description><identifier>ISSN: 0931-0509</identifier><identifier>EISSN: 1460-2385</identifier><identifier>DOI: 10.1093/ndt/gfp045</identifier><identifier>PMID: 19223275</identifier><identifier>CODEN: NDTREA</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Adult ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Antigens, CD - metabolism ; Antigens, Differentiation, Myelomonocytic - metabolism ; Arteritis - etiology ; Arteritis - immunology ; Arteritis - pathology ; Biological and medical sciences ; CD3 Complex - metabolism ; Emergency and intensive care: renal failure. Dialysis management ; Female ; Graft Rejection - etiology ; Graft Rejection - immunology ; Graft Rejection - pathology ; Humans ; Intensive care medicine ; intimal arteritis ; Kaplan-Meier Estimate ; kidney allograft ; Kidney Transplantation - adverse effects ; Kidney Transplantation - immunology ; Kidney Transplantation - pathology ; lymphocyte ; macrophage ; Macrophages - immunology ; Male ; Medical sciences ; Middle Aged ; monocyte ; Monocytes - immunology ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Surgery of the urinary system ; T-Lymphocytes - immunology ; T-Lymphocytes - pathology ; Transplantation, Homologous ; Treatment Outcome ; Tunica Intima - immunology ; Tunica Intima - pathology</subject><ispartof>Nephrology, dialysis, transplantation, 2009-06, Vol.24 (6), p.1979-1986</ispartof><rights>Oxford University Press © The Author [2009]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org 2009</rights><rights>2009 INIST-CNRS</rights><rights>The Author [2009]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org</rights><rights>The Author [2009]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. 2009</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c462t-9d75f26bf1e7b77dc61e66481edab94886059b5ff6a71e469145947b44f76b3c3</citedby><cites>FETCH-LOGICAL-c462t-9d75f26bf1e7b77dc61e66481edab94886059b5ff6a71e469145947b44f76b3c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,1578,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21556249$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19223275$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kozakowski, Nicolas</creatorcontrib><creatorcontrib>Böhmig, Georg A.</creatorcontrib><creatorcontrib>Exner, Markus</creatorcontrib><creatorcontrib>Soleiman, Afschin</creatorcontrib><creatorcontrib>Huttary, Nicole</creatorcontrib><creatorcontrib>Nagy-Bojarszky, Katalin</creatorcontrib><creatorcontrib>Ecker, Rupert C.</creatorcontrib><creatorcontrib>Kikić, Željko</creatorcontrib><creatorcontrib>Regele, Heinz</creatorcontrib><title>Monocytes/macrophages in kidney allograft intimal arteritis: no association with markers of humoral rejection or with inferior outcome</title><title>Nephrology, dialysis, transplantation</title><addtitle>Nephrol Dial Transplant</addtitle><addtitle>Nephrol Dial Transplant</addtitle><description>Background. Several studies indicate that interstitial and intracapillary monocytes/macrophages (MO) represent a significant proportion of graft-infiltrating cells in renal allografts and that their presence may unfavourably affect clinical outcome. Much less is known about the role of MO in vascular rejection of transplanted kidneys. The aim of our study was to determine the cellular composition of immune cell infiltrates in intimal arteritis and to analyse whether it is associated with features of humoral immunity and impaired graft survival. Methods. In 34 recipients with vascular rejection, we determined the proportion of intimal and interstitial MO and T-cells (expressed as ratio of CD68- and CD3-positive cells) in immunohistochemically double-labelled slides. Results. Intimal arteritis is always composed of T-cells and MO with a median CD68/CD3 ratio of 1.03. In 47% of cases, however, T-cells predominate (CD68/CD3 ratio <1). The median interstitial CD68/CD3 ratio is 0.61, with T-cells dominating in 64% of cases. There is no correlation between the cellular composition of arterial and interstitial infiltrates. The proportion of interstitial and arterial MO has no impact on graft survival, and is, in contrast to previous reports on MO in allograft glomerulitis and capillaritis, not associated with C4d staining. Conclusions. Intimal arteritis in kidney allograft rejection is composed of a mixed infiltrate of MO and T-lymphocytes. In contrast to MO in PTCitis and glomerulitis, the MO in intimal arteritis are not associated with markers of humoral immune response and there are no different allograft outcomes between MO and T-lymphocyte-dominated groups.</description><subject>Adult</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Antigens, CD - metabolism</subject><subject>Antigens, Differentiation, Myelomonocytic - metabolism</subject><subject>Arteritis - etiology</subject><subject>Arteritis - immunology</subject><subject>Arteritis - pathology</subject><subject>Biological and medical sciences</subject><subject>CD3 Complex - metabolism</subject><subject>Emergency and intensive care: renal failure. Dialysis management</subject><subject>Female</subject><subject>Graft Rejection - etiology</subject><subject>Graft Rejection - immunology</subject><subject>Graft Rejection - pathology</subject><subject>Humans</subject><subject>Intensive care medicine</subject><subject>intimal arteritis</subject><subject>Kaplan-Meier Estimate</subject><subject>kidney allograft</subject><subject>Kidney Transplantation - adverse effects</subject><subject>Kidney Transplantation - immunology</subject><subject>Kidney Transplantation - pathology</subject><subject>lymphocyte</subject><subject>macrophage</subject><subject>Macrophages - immunology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>monocyte</subject><subject>Monocytes - immunology</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Surgery of the urinary system</subject><subject>T-Lymphocytes - immunology</subject><subject>T-Lymphocytes - pathology</subject><subject>Transplantation, Homologous</subject><subject>Treatment Outcome</subject><subject>Tunica Intima - immunology</subject><subject>Tunica Intima - pathology</subject><issn>0931-0509</issn><issn>1460-2385</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkk-PEyEYxonRuLV68QOYiYkeTMYCw59hDyZu47oma7xoNF4Iw0BLdwYqMGq_gJ9b1jZd9aAnAu-Ph_fleQB4iOBzBEWz8H1erOwWEnoLzBBhsMZNS2-DWSmiGlIoTsC9lDYQQoE5vwtOkMC4wZzOwI-3wQe9yyYtRqVj2K7VyqTK-erK9d7sKjUMYRWVzeUsu1ENlYrZRJddOq18qFRKQTuVXfDVN5fX1ajilYmpCrZaT2OI5UY0G6N_ESHuIedt0Si7MGUdRnMf3LFqSObBYZ2DD-ev3i8v6st3r98sX17WmjCca9FzajHrLDK847zXDBnGSItMrzpB2pZBKjpqLVMcGcIEIlQQ3hFiOesa3czBi73udupG02vjc2lQbmOZLO5kUE7-WfFuLVfhq8RCcNw2ReDpQSCGL5NJWY4uaTMMypswJckKhSET_wULxIpV14qP_wI3YYq-_ILEqEWMoOLVHDzbQ8WilKKxx5YRlNchkCUEch-CAj_6fcgb9OB6AZ4cAJW0GmxUXrt05DCilGEibrgwbf_9YL3nXMrm-5EsQSj_0XAqLz59lmfnDH9EZ0u5bH4CuQHaRw</recordid><startdate>20090601</startdate><enddate>20090601</enddate><creator>Kozakowski, Nicolas</creator><creator>Böhmig, Georg A.</creator><creator>Exner, Markus</creator><creator>Soleiman, Afschin</creator><creator>Huttary, Nicole</creator><creator>Nagy-Bojarszky, Katalin</creator><creator>Ecker, Rupert C.</creator><creator>Kikić, Željko</creator><creator>Regele, Heinz</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20090601</creationdate><title>Monocytes/macrophages in kidney allograft intimal arteritis: no association with markers of humoral rejection or with inferior outcome</title><author>Kozakowski, Nicolas ; Böhmig, Georg A. ; Exner, Markus ; Soleiman, Afschin ; Huttary, Nicole ; Nagy-Bojarszky, Katalin ; Ecker, Rupert C. ; Kikić, Željko ; Regele, Heinz</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c462t-9d75f26bf1e7b77dc61e66481edab94886059b5ff6a71e469145947b44f76b3c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adult</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Antigens, CD - metabolism</topic><topic>Antigens, Differentiation, Myelomonocytic - metabolism</topic><topic>Arteritis - etiology</topic><topic>Arteritis - immunology</topic><topic>Arteritis - pathology</topic><topic>Biological and medical sciences</topic><topic>CD3 Complex - metabolism</topic><topic>Emergency and intensive care: renal failure. Dialysis management</topic><topic>Female</topic><topic>Graft Rejection - etiology</topic><topic>Graft Rejection - immunology</topic><topic>Graft Rejection - pathology</topic><topic>Humans</topic><topic>Intensive care medicine</topic><topic>intimal arteritis</topic><topic>Kaplan-Meier Estimate</topic><topic>kidney allograft</topic><topic>Kidney Transplantation - adverse effects</topic><topic>Kidney Transplantation - immunology</topic><topic>Kidney Transplantation - pathology</topic><topic>lymphocyte</topic><topic>macrophage</topic><topic>Macrophages - immunology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>monocyte</topic><topic>Monocytes - immunology</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Surgery of the urinary system</topic><topic>T-Lymphocytes - immunology</topic><topic>T-Lymphocytes - pathology</topic><topic>Transplantation, Homologous</topic><topic>Treatment Outcome</topic><topic>Tunica Intima - immunology</topic><topic>Tunica Intima - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kozakowski, Nicolas</creatorcontrib><creatorcontrib>Böhmig, Georg A.</creatorcontrib><creatorcontrib>Exner, Markus</creatorcontrib><creatorcontrib>Soleiman, Afschin</creatorcontrib><creatorcontrib>Huttary, Nicole</creatorcontrib><creatorcontrib>Nagy-Bojarszky, Katalin</creatorcontrib><creatorcontrib>Ecker, Rupert C.</creatorcontrib><creatorcontrib>Kikić, Željko</creatorcontrib><creatorcontrib>Regele, Heinz</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Nephrology, dialysis, transplantation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kozakowski, Nicolas</au><au>Böhmig, Georg A.</au><au>Exner, Markus</au><au>Soleiman, Afschin</au><au>Huttary, Nicole</au><au>Nagy-Bojarszky, Katalin</au><au>Ecker, Rupert C.</au><au>Kikić, Željko</au><au>Regele, Heinz</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Monocytes/macrophages in kidney allograft intimal arteritis: no association with markers of humoral rejection or with inferior outcome</atitle><jtitle>Nephrology, dialysis, transplantation</jtitle><stitle>Nephrol Dial Transplant</stitle><addtitle>Nephrol Dial Transplant</addtitle><date>2009-06-01</date><risdate>2009</risdate><volume>24</volume><issue>6</issue><spage>1979</spage><epage>1986</epage><pages>1979-1986</pages><issn>0931-0509</issn><eissn>1460-2385</eissn><coden>NDTREA</coden><abstract>Background. Several studies indicate that interstitial and intracapillary monocytes/macrophages (MO) represent a significant proportion of graft-infiltrating cells in renal allografts and that their presence may unfavourably affect clinical outcome. Much less is known about the role of MO in vascular rejection of transplanted kidneys. The aim of our study was to determine the cellular composition of immune cell infiltrates in intimal arteritis and to analyse whether it is associated with features of humoral immunity and impaired graft survival. Methods. In 34 recipients with vascular rejection, we determined the proportion of intimal and interstitial MO and T-cells (expressed as ratio of CD68- and CD3-positive cells) in immunohistochemically double-labelled slides. Results. Intimal arteritis is always composed of T-cells and MO with a median CD68/CD3 ratio of 1.03. In 47% of cases, however, T-cells predominate (CD68/CD3 ratio <1). The median interstitial CD68/CD3 ratio is 0.61, with T-cells dominating in 64% of cases. There is no correlation between the cellular composition of arterial and interstitial infiltrates. The proportion of interstitial and arterial MO has no impact on graft survival, and is, in contrast to previous reports on MO in allograft glomerulitis and capillaritis, not associated with C4d staining. Conclusions. Intimal arteritis in kidney allograft rejection is composed of a mixed infiltrate of MO and T-lymphocytes. In contrast to MO in PTCitis and glomerulitis, the MO in intimal arteritis are not associated with markers of humoral immune response and there are no different allograft outcomes between MO and T-lymphocyte-dominated groups.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>19223275</pmid><doi>10.1093/ndt/gfp045</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Adult Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Antigens, CD - metabolism Antigens, Differentiation, Myelomonocytic - metabolism Arteritis - etiology Arteritis - immunology Arteritis - pathology Biological and medical sciences CD3 Complex - metabolism Emergency and intensive care: renal failure. Dialysis management Female Graft Rejection - etiology Graft Rejection - immunology Graft Rejection - pathology Humans Intensive care medicine intimal arteritis Kaplan-Meier Estimate kidney allograft Kidney Transplantation - adverse effects Kidney Transplantation - immunology Kidney Transplantation - pathology lymphocyte macrophage Macrophages - immunology Male Medical sciences Middle Aged monocyte Monocytes - immunology Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the urinary system T-Lymphocytes - immunology T-Lymphocytes - pathology Transplantation, Homologous Treatment Outcome Tunica Intima - immunology Tunica Intima - pathology |
| title | Monocytes/macrophages in kidney allograft intimal arteritis: no association with markers of humoral rejection or with inferior outcome |
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