Enthalpy--Entropy Compensations in Drug-DNA Binding Studies

We present a comparative study of calorimetrically derived thermodynamic profiles for the binding of a series of drugs with selected DNA host duplexes. We use these data to demonstrate that comparisons between complete thermodynamic profiles (Δ G degrees, Δ H degrees, Δ S degrees, Δ Cp) are required...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1987-12, Vol.84 (24), p.8922-8926
Hauptverfasser:	Breslauer, Kenneth J., Remeta, David P., Chou, Wan-Yin, Ferrante, Robert, Curry, James, Zaunczkowski, Denise, Snyder, James G., Marky, Luis A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemistry Biological and medical sciences Calorimetry Copolymers Daunorubicin Distamycins DNA DNA Damage Electrostatics Enthalpy Entropy Ethidium Free energy Fundamental and applied biological sciences. Psychology Guanidines Interactions. Associations Intercalating Agents Intermolecular phenomena Ligands Melting Molecular biophysics Netropsin Nucleic Acid Conformation Nucleic acids Poly dA-dT Pyrroles Salts Thermodynamics
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