Physiological levels of ATP negatively regulate proteasome function

Intracellular protein degradation by the ubiquitin-proteasome system is ATP dependent, and the optimal ATP concentration to activate proteasome function in vitro is -100 μM. IntraceUular ATP levels are generally in the low millimolar range, but ATP at a level within this range was shown to inhibit p...

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Veröffentlicht in:	Cell research 2010-12, Vol.20 (12), p.1372-1385
Hauptverfasser:	Huang, Hongbiao, Zhang, Xiaoyan, Li, Shujue, Liu, Ningning, Lian, Wen, McDowell, Emily, Zhou, Ping, Zhao, Canguo, Guo, Haiping, Zhang, Change, Yang, Changshan, Wen, Guangmei, Dong, Xiaoxian, Lu, Li, Ma, Ningfang, Dong, Weihua, Dou, Q. Ping, Wang, Xuejun, Liu, Jinbao
Format:	Artikel
Sprache:	eng
Schlagworte:	26S蛋白酶体 631/337/474/2085 631/443 Adenosine Triphosphate - metabolism Adenosine Triphosphate - physiology Apoptosis ATP ATP浓度 Biodegradation Biomedical and Life Sciences Boronic Acids - pharmacology Cell Biology Cell Line Humans Leupeptins - pharmacology Life Sciences Microscopy, Fluorescence Oligomycins - pharmacology original-article Physiology Proteasome Endopeptidase Complex - metabolism Proteasome Endopeptidase Complex - physiology Time Factors Ubiquitin - metabolism 三磷酸腺苷双向调节细胞内蛋白水平负调节
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