How long is too long? Effects of loop size on G-quadruplex stability

We compared here 80 different sequences containing four tracts of three guanines with loops of variable length (between 1 and 15 bases for unmodified sequences, up to 30 for fluorescently labeled oligonucleotides). All sequences were capable of forming stable quadruplexes, with Tm above physiologica...

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Veröffentlicht in:	Nucleic acids research 2010-11, Vol.38 (21), p.7858-7868
Hauptverfasser:	Guédin, Aurore, Gros, Julien, Alberti, Patrizia, Mergny, Jean-Louis
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence Circular Dichroism Conserved sequence Fluorescence Resonance Energy Transfer G-Quadruplexes Guanine Melting Nucleic Acid Denaturation Oligonucleotides Potassium Potassium - chemistry Sodium Sodium - chemistry Synthetic Biology and Chemistry Temperature Temperature effects Thymine - chemistry
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