Lack of association of CFD polymorphisms with advanced age-related macular degeneration

Age-related macular degeneration (AMD) is the most common cause of irreversible central vision loss worldwide. Research has linked AMD susceptibility with dysregulation of the complement cascade. Typically, complement factor H (CFH), complement factor B (CFB), complement component 2 (C2), and comple...

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Veröffentlicht in:	Molecular vision 2010-11, Vol.16, p.2273-2278
Hauptverfasser:	Zeng, Jiexi, Chen, Yuhong, Tong, Zongzhong, Zhou, Xinrong, Zhao, Chao, Wang, Kevin, Hughes, Guy, Kasuga, Daniel, Bedell, Matthew, Lee, Clara, Ferreyra, Henry, Kozak, Igor, Haw, Weldon, Guan, Jean, Shaw, Robert, Stevenson, William, Weishaar, Paul D, Nelson, Mark H, Tang, Luosheng, Zhang, Kang
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence Complement Factor D - genetics Complement Pathway, Alternative - genetics Genetic Association Studies Genetic Predisposition to Disease Humans Linkage Disequilibrium - genetics Macular Degeneration - genetics Macular Degeneration - pathology Middle Aged Molecular Sequence Data Polymorphism, Single Nucleotide - genetics
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