Modular Utilization of Distal cis-Regulatory Elements Controls Ifng Gene Expression in T Cells Activated by Distinct Stimuli

Distal cis-regulatory elements play essential roles in the T lineage-specific expression of cytokine genes. We have mapped interactions of three trans-acting factors—NF-κB, STAT4, and T-bet—with cis elements in the Ifng locus. We find that RelA is critical for optimal Ifng expression and is differen...

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Veröffentlicht in:	Immunity (Cambridge, Mass.) Mass.), 2010-07, Vol.33 (1), p.35-47
Hauptverfasser:	Balasubramani, Anand, Shibata, Yoichiro, Crawford, Gregory E., Baldwin, Albert S., Hatton, Robin D., Weaver, Casey T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - metabolism CD8-Positive T-Lymphocytes - pathology Cell Differentiation CELLIMMUNO Cells, Cultured Chromatin Assembly and Disassembly - genetics Deoxyribonucleic acid DNA Gene expression Gene loci Interferon-gamma - genetics Interferon-gamma - metabolism Interleukin-12 - immunology Interleukin-12 - metabolism Interleukin-18 - immunology Interleukin-18 - metabolism Mice Mice, Inbred C57BL Mice, Knockout Mice, Transgenic MOLIMMUNO NF-kappa B - genetics NF-kappa B - metabolism Receptors, Antigen, T-Cell - genetics Receptors, Antigen, T-Cell - metabolism Recruitment Regulatory Elements, Transcriptional - genetics STAT4 Transcription Factor - genetics STAT4 Transcription Factor - metabolism Studies SYSBIO T-Box Domain Proteins - genetics T-Box Domain Proteins - immunology T-Box Domain Proteins - metabolism Th1 Cells - immunology Th1 Cells - metabolism Th1 Cells - pathology Transcription Factor RelA - genetics Transcription Factor RelA - immunology Transcription Factor RelA - metabolism Transcription factors Transcriptional Activation
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