Mantle cell lymphoma activation enhances bortezomib sensitivity

Patients with mantle cell lymphoma (MCL) typically respond to initial treatment but subsequently relapse. This pattern suggests that a population of MCL cells is both drug resistant and capable of clonogenic growth. The intracellular enzyme retinaldehyde dehydrogenase (ALDH) provides resistance to s...

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Veröffentlicht in:	Blood 2010-11, Vol.116 (20), p.4185-4191
Hauptverfasser:	Brennan, Sarah K., Meade, Brooke, Wang, Qiuju, Merchant, Akil A., Kowalski, Jeanne, Matsui, William
Format:	Artikel
Sprache:	eng
Schlagworte:	Aldehyde Dehydrogenase - metabolism Aldehyde Dehydrogenase 1 Family Animals Biological and medical sciences Boronic Acids - pharmacology Bortezomib Cell Differentiation - drug effects Cell Line, Tumor Cell Proliferation - drug effects Clone Cells Drug Resistance, Neoplasm - drug effects Drug Screening Assays, Antitumor Hematologic and hematopoietic diseases Humans Isoenzymes - metabolism Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymphocyte Activation - drug effects Lymphocyte Activation - immunology Lymphoid Neoplasia Lymphoma, Mantle-Cell - enzymology Lymphoma, Mantle-Cell - pathology Medical sciences Mice Oligodeoxyribonucleotides - pharmacology Plasma Cells - drug effects Plasma Cells - pathology Proteasome Endopeptidase Complex - metabolism Proteasome Inhibitors Pyrazines - pharmacology Retinal Dehydrogenase Toll-Like Receptor 9 - immunology Unfolded Protein Response - drug effects
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