Melanoma differentiation associated gene-7/interleukin-24 potently induces apoptosis in human myeloid leukemia cells through a process regulated by endoplasmic reticulum stress

Melanoma differentiation associated gene-7 (mda-7)/interleukin-24 (IL-24), a member of the IL-10 cytokine gene family, preferentially induces cell death in neoplastic epithelial cells types while sparing their normal counterparts. The effects of mda-7/IL-24 in acute myeloid leukemia (AML) cells have...

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Veröffentlicht in:	Molecular pharmacology 2010-12, Vol.78 (6), p.1096-1104
Hauptverfasser:	Rahmani, Mohamed, Mayo, Mandy, Dash, Rupesh, Sokhi, Upneet Kaur, Dmitriev, Igor P, Sarkar, Devanand, Dent, Paul, Curiel, David T, Fisher, Paul B, Grant, Steven
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis - physiology Cell Differentiation - physiology Cell Transformation, Neoplastic - pathology Cells, Cultured Endoplasmic Reticulum - pathology HL-60 Cells Humans Interleukins - physiology Leukemia, Myeloid - metabolism Leukemia, Myeloid - pathology Stem Cells - pathology Stress, Physiological - physiology U937 Cells
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