Innate Immune Detection of Bacterial Virulence Factors Via the NLRC4 Inflammasome
Introduction Cytokine production by innate immune cells is initiated by signaling downstream of pattern recognition receptors, including Toll-like receptors. Discussion A subset of cytokines, including IL-1β and IL-18, require post-translational proteolysis before secretion, which provides a second...
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| Veröffentlicht in: | Journal of clinical immunology 2010-07, Vol.30 (4), p.502-506 |
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| description | Introduction Cytokine production by innate immune cells is initiated by signaling downstream of pattern recognition receptors, including Toll-like receptors. Discussion A subset of cytokines, including IL-1β and IL-18, require post-translational proteolysis before secretion, which provides a second mechanism of regulation. This proteolysis is dependent upon caspase 1, which is activated by Nod-like receptor (NLR) signaling. NLRC4 (previously named Ipaf) activates caspase 1 in response to bacterial virulence factors including type III and IV secretion systems (T3SS and T4SS). NLRC4 recognizes T3SS/T4SS in two ways: indirectly by detecting flagellin, and directly by detecting the T3SS rod protein. Both flagellin and rod protein are unintentionally delivered to the mammalian cytosol by the bacterium through the T3SS. |
| doi_str_mv | 10.1007/s10875-010-9386-5 |
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Discussion A subset of cytokines, including IL-1β and IL-18, require post-translational proteolysis before secretion, which provides a second mechanism of regulation. This proteolysis is dependent upon caspase 1, which is activated by Nod-like receptor (NLR) signaling. NLRC4 (previously named Ipaf) activates caspase 1 in response to bacterial virulence factors including type III and IV secretion systems (T3SS and T4SS). NLRC4 recognizes T3SS/T4SS in two ways: indirectly by detecting flagellin, and directly by detecting the T3SS rod protein. Both flagellin and rod protein are unintentionally delivered to the mammalian cytosol by the bacterium through the T3SS.</description><identifier>ISSN: 0271-9142</identifier><identifier>EISSN: 1573-2592</identifier><identifier>DOI: 10.1007/s10875-010-9386-5</identifier><identifier>PMID: 20349122</identifier><identifier>CODEN: JCIMDO</identifier><language>eng</language><publisher>Boston: Boston : Springer US</publisher><subject>Bacteria ; Bacteria - immunology ; Bacteria - pathogenicity ; Biomedical and Life Sciences ; Biomedicine ; Calcium-Binding Proteins - immunology ; CARD Signaling Adaptor Proteins - immunology ; Caspase-1 ; Cytosol ; Flagellin ; Humans ; IL-1β ; Immunity, Innate ; Immunology ; Infectious Diseases ; inflammation ; Interleukin 1 ; Interleukin 18 ; Internal Medicine ; Medical Microbiology ; NLRC4 ; Pattern recognition ; Post-translation ; Proteolysis ; Receptors, Pattern Recognition ; Toll-like receptors ; type III secretion ; Virulence Factors</subject><ispartof>Journal of clinical immunology, 2010-07, Vol.30 (4), p.502-506</ispartof><rights>Springer Science+Business Media, LLC 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c590t-9c145cff3007a54ee6da0a737b7f772896708a8864bfd84b7e4752dfea2cf5223</citedby><cites>FETCH-LOGICAL-c590t-9c145cff3007a54ee6da0a737b7f772896708a8864bfd84b7e4752dfea2cf5223</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10875-010-9386-5$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10875-010-9386-5$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20349122$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Miao, Edward A</creatorcontrib><creatorcontrib>Warren, Sarah E</creatorcontrib><title>Innate Immune Detection of Bacterial Virulence Factors Via the NLRC4 Inflammasome</title><title>Journal of clinical immunology</title><addtitle>J Clin Immunol</addtitle><addtitle>J Clin Immunol</addtitle><description>Introduction Cytokine production by innate immune cells is initiated by signaling downstream of pattern recognition receptors, including Toll-like receptors. Discussion A subset of cytokines, including IL-1β and IL-18, require post-translational proteolysis before secretion, which provides a second mechanism of regulation. This proteolysis is dependent upon caspase 1, which is activated by Nod-like receptor (NLR) signaling. NLRC4 (previously named Ipaf) activates caspase 1 in response to bacterial virulence factors including type III and IV secretion systems (T3SS and T4SS). NLRC4 recognizes T3SS/T4SS in two ways: indirectly by detecting flagellin, and directly by detecting the T3SS rod protein. Both flagellin and rod protein are unintentionally delivered to the mammalian cytosol by the bacterium through the T3SS.</description><subject>Bacteria</subject><subject>Bacteria - immunology</subject><subject>Bacteria - pathogenicity</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Calcium-Binding Proteins - immunology</subject><subject>CARD Signaling Adaptor Proteins - immunology</subject><subject>Caspase-1</subject><subject>Cytosol</subject><subject>Flagellin</subject><subject>Humans</subject><subject>IL-1β</subject><subject>Immunity, Innate</subject><subject>Immunology</subject><subject>Infectious Diseases</subject><subject>inflammation</subject><subject>Interleukin 1</subject><subject>Interleukin 18</subject><subject>Internal Medicine</subject><subject>Medical Microbiology</subject><subject>NLRC4</subject><subject>Pattern recognition</subject><subject>Post-translation</subject><subject>Proteolysis</subject><subject>Receptors, Pattern Recognition</subject><subject>Toll-like receptors</subject><subject>type III secretion</subject><subject>Virulence Factors</subject><issn>0271-9142</issn><issn>1573-2592</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkU1v1DAQhi0EotuFH8AFIi49BcZjO44vSGWhsNIKxEe5Wt7seJsqsYudIPHvcbWlfBzgZGnmeV_PzMvYIw7POIB-njm0WtXAoTaibWp1hy240qJGZfAuWwBqXhsu8Ygd53wJAKJBdZ8dIQhpOOKCfViH4Caq1uM4B6pe0UTd1MdQRV-9dN1EqXdD9aVP80Cho-qs1GLKpeKq6YKqd5uPK1mtgx_cOLocR3rA7nk3ZHp48y7Z-dnrz6u39eb9m_XqdFN3ysBUm45L1XkvyiJOSaJm58Bpobfaa42taTS0rm0bufW7Vm41Sa1w58lh5xWiWLIXB9-reTvSrqMwJTfYq9SPLn230fX2z07oL-w-frNojEDJi8HJjUGKX2fKkx373NEwuEBxzlbLRnBA1P8nhWiUgsIv2dO_yMs4p1DuYBswpkEjTYH4AepSzDmRvx2ag70O1h6CtSVYex2sVUXz-PdtbxU_kywAHoBcWmFP6dfP_3J9chB5F63bpz7b808IXAAvhzcSxQ_9KLZY</recordid><startdate>20100701</startdate><enddate>20100701</enddate><creator>Miao, Edward A</creator><creator>Warren, Sarah E</creator><general>Boston : Springer US</general><general>Springer US</general><general>Springer Nature B.V</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQGLB</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>7QL</scope><scope>7T7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>5PM</scope></search><sort><creationdate>20100701</creationdate><title>Innate Immune Detection of Bacterial Virulence Factors Via the NLRC4 Inflammasome</title><author>Miao, Edward A ; Warren, Sarah E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c590t-9c145cff3007a54ee6da0a737b7f772896708a8864bfd84b7e4752dfea2cf5223</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Bacteria</topic><topic>Bacteria - immunology</topic><topic>Bacteria - pathogenicity</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Calcium-Binding Proteins - immunology</topic><topic>CARD Signaling Adaptor Proteins - immunology</topic><topic>Caspase-1</topic><topic>Cytosol</topic><topic>Flagellin</topic><topic>Humans</topic><topic>IL-1β</topic><topic>Immunity, Innate</topic><topic>Immunology</topic><topic>Infectious Diseases</topic><topic>inflammation</topic><topic>Interleukin 1</topic><topic>Interleukin 18</topic><topic>Internal Medicine</topic><topic>Medical Microbiology</topic><topic>NLRC4</topic><topic>Pattern recognition</topic><topic>Post-translation</topic><topic>Proteolysis</topic><topic>Receptors, Pattern Recognition</topic><topic>Toll-like receptors</topic><topic>type III secretion</topic><topic>Virulence Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Miao, Edward A</creatorcontrib><creatorcontrib>Warren, Sarah E</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>ProQuest Health & Medical Research Collection</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Health & Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Applied & Life Sciences</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - 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| subjects | Bacteria Bacteria - immunology Bacteria - pathogenicity Biomedical and Life Sciences Biomedicine Calcium-Binding Proteins - immunology CARD Signaling Adaptor Proteins - immunology Caspase-1 Cytosol Flagellin Humans IL-1β Immunity, Innate Immunology Infectious Diseases inflammation Interleukin 1 Interleukin 18 Internal Medicine Medical Microbiology NLRC4 Pattern recognition Post-translation Proteolysis Receptors, Pattern Recognition Toll-like receptors type III secretion Virulence Factors |
| title | Innate Immune Detection of Bacterial Virulence Factors Via the NLRC4 Inflammasome |
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