Short-term exercise training protects against doxorubicin-induced cardiac mitochondrial damage independent of HSP72

Doxorubicin (Dox) is an antitumor agent used in cancer treatment, but its clinical use is limited due to cardiotoxicity. Although exercise training can defend against Dox-mediated cardiac damage, the means for this cardioprotection remain unknown. To investigate the mechanism(s) responsible for exer...

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Veröffentlicht in:	American journal of physiology. Heart and circulatory physiology 2010-11, Vol.299 (5), p.H1515-H1524
Hauptverfasser:	Kavazis, Andreas N, Smuder, Ashley J, Min, Kisuk, Tümer, Nihal, Powers, Scott K
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Apoptosis - drug effects Calcium - metabolism Cardiotoxins - adverse effects Cardiotoxins - pharmacology Cells Doxorubicin - adverse effects Doxorubicin - pharmacology Enzymes Exercise Genotype & phenotype Heart HSP72 Heat-Shock Proteins - metabolism Lipid Peroxides - metabolism Male Mitochondria, Heart - drug effects Mitochondria, Heart - physiology Mitochondrial Diseases - chemically induced Mitochondrial Diseases - metabolism Mitochondrial Diseases - prevention & control Models, Animal Myocytes, Cardiac - drug effects Myocytes, Cardiac - metabolism Myocytes, Cardiac - pathology Oxidative Stress - drug effects Physical Conditioning, Animal - physiology Protein Isoforms - metabolism Proteins Rats Rats, Sprague-Dawley Reactive Oxygen Species - metabolism Toxicity Tumors
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