Differential Adaptation of Human Gut Microbiota to Bariatric Surgery-Induced Weight Loss: Links With Metabolic and Low-Grade Inflammation Markers
Obesity alters gut microbiota ecology and associates with low-grade inflammation in humans. Roux-en-Y gastric bypass (RYGB) surgery is one of the most efficient procedures for the treatment of morbid obesity resulting in drastic weight loss and improvement of metabolic and inflammatory status. We an...
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| Veröffentlicht in: | Diabetes (New York, N.Y.) N.Y.), 2010-12, Vol.59 (12), p.3049-3057 |
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| creator | FURET, Jean-Pierre KONG, Ling-Chun RIZKALLA, Salwa CLEMENT, Karine TAP, Julien POITOU, Christine BASDEVANT, Arnaud BOUILLOT, Jean-Luc MARIAT, Denis CORTHIER, Gérard DORE, Joël HENEGAR, Corneliu |
| description | Obesity alters gut microbiota ecology and associates with low-grade inflammation in humans. Roux-en-Y gastric bypass (RYGB) surgery is one of the most efficient procedures for the treatment of morbid obesity resulting in drastic weight loss and improvement of metabolic and inflammatory status. We analyzed the impact of RYGB on the modifications of gut microbiota and examined links with adaptations associated with this procedure.
Gut microbiota was profiled from fecal samples by real-time quantitative PCR in 13 lean control subjects and in 30 obese individuals (with seven type 2 diabetics) explored before (M0), 3 months (M3), and 6 months (M6) after RYGB.
Four major findings are highlighted: 1) Bacteroides/Prevotella group was lower in obese subjects than in control subjects at M0 and increased at M3. It was negatively correlated with corpulence, but the correlation depended highly on caloric intake; 2) Escherichia coli species increased at M3 and inversely correlated with fat mass and leptin levels independently of changes in food intake; 3) lactic acid bacteria including Lactobacillus/Leuconostoc/Pediococcus group and Bifidobacterium genus decreased at M3; and 4) Faecalibacterium prausnitzii species was lower in subjects with diabetes and associated negatively with inflammatory markers at M0 and throughout the follow-up after surgery independently of changes in food intake.
These results suggest that components of the dominant gut microbiota rapidly adapt in a starvation-like situation induced by RYGB while the F. prausnitzii species is directly linked to the reduction in low-grade inflammation state in obesity and diabetes independently of calorie intake. |
| doi_str_mv | 10.2337/db10-0253 |
| format | Article |
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Gut microbiota was profiled from fecal samples by real-time quantitative PCR in 13 lean control subjects and in 30 obese individuals (with seven type 2 diabetics) explored before (M0), 3 months (M3), and 6 months (M6) after RYGB.
Four major findings are highlighted: 1) Bacteroides/Prevotella group was lower in obese subjects than in control subjects at M0 and increased at M3. It was negatively correlated with corpulence, but the correlation depended highly on caloric intake; 2) Escherichia coli species increased at M3 and inversely correlated with fat mass and leptin levels independently of changes in food intake; 3) lactic acid bacteria including Lactobacillus/Leuconostoc/Pediococcus group and Bifidobacterium genus decreased at M3; and 4) Faecalibacterium prausnitzii species was lower in subjects with diabetes and associated negatively with inflammatory markers at M0 and throughout the follow-up after surgery independently of changes in food intake.
These results suggest that components of the dominant gut microbiota rapidly adapt in a starvation-like situation induced by RYGB while the F. prausnitzii species is directly linked to the reduction in low-grade inflammation state in obesity and diabetes independently of calorie intake.</description><identifier>ISSN: 0012-1797</identifier><identifier>EISSN: 1939-327X</identifier><identifier>DOI: 10.2337/db10-0253</identifier><identifier>PMID: 20876719</identifier><identifier>CODEN: DIAEAZ</identifier><language>eng</language><publisher>Alexandria, VA: American Diabetes Association</publisher><subject><![CDATA[Adaptation, Physiological ; Analysis ; Bacteroides ; Bacteroides - genetics ; Bacteroides - isolation & purification ; Bariatric Surgery ; Bifidobacterium ; Bifidobacterium - genetics ; Bifidobacterium - isolation & purification ; Biological and medical sciences ; Blood Glucose - metabolism ; Body composition ; Body fat ; Calories ; Care and treatment ; Clostridium - genetics ; Clostridium - isolation & purification ; Diabetes ; Diabetes. Impaired glucose tolerance ; DNA Primers ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Escherichia coli ; Escherichia coli - isolation & purification ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Faecalibacterium prausnitzii ; Feces ; Feces - microbiology ; Female ; Food ; Gastrointestinal surgery ; Glucose ; Humans ; Inflammation ; Inflammation - etiology ; Inflammation - microbiology ; Inflammation - physiopathology ; Insulin ; Lactobacillus ; Lactobacillus - isolation & purification ; Leptin ; Leuconostoc ; Leuconostoc - isolation & purification ; Life Sciences ; Male ; Medical sciences ; Metabolism ; Microbiota ; Microbiota (Symbiotic organisms) ; Obesity ; Obesity - microbiology ; Obesity Studies ; Patient outcomes ; Pediococcus ; Pediococcus - isolation & purification ; Physiological aspects ; Polymerase Chain Reaction ; Prevotella ; Research design ; Starvation - microbiology ; Surgery ; Thinness - microbiology ; Weight control ; Weight loss ; Weight Loss - physiology]]></subject><ispartof>Diabetes (New York, N.Y.), 2010-12, Vol.59 (12), p.3049-3057</ispartof><rights>2015 INIST-CNRS</rights><rights>COPYRIGHT 2010 American Diabetes Association</rights><rights>COPYRIGHT 2010 American Diabetes Association</rights><rights>Copyright American Diabetes Association Dec 2010</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><rights>2010 by the American Diabetes Association.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000-0001-8998-5413 ; 0000-0003-4619-6785 ; 0000-0001-7769-6331 ; 0000-0002-2489-3355</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2992765/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2992765/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23746920$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20876719$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.inrae.fr/hal-02668840$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>FURET, Jean-Pierre</creatorcontrib><creatorcontrib>KONG, Ling-Chun</creatorcontrib><creatorcontrib>RIZKALLA, Salwa</creatorcontrib><creatorcontrib>CLEMENT, Karine</creatorcontrib><creatorcontrib>TAP, Julien</creatorcontrib><creatorcontrib>POITOU, Christine</creatorcontrib><creatorcontrib>BASDEVANT, Arnaud</creatorcontrib><creatorcontrib>BOUILLOT, Jean-Luc</creatorcontrib><creatorcontrib>MARIAT, Denis</creatorcontrib><creatorcontrib>CORTHIER, Gérard</creatorcontrib><creatorcontrib>DORE, Joël</creatorcontrib><creatorcontrib>HENEGAR, Corneliu</creatorcontrib><title>Differential Adaptation of Human Gut Microbiota to Bariatric Surgery-Induced Weight Loss: Links With Metabolic and Low-Grade Inflammation Markers</title><title>Diabetes (New York, N.Y.)</title><addtitle>Diabetes</addtitle><description>Obesity alters gut microbiota ecology and associates with low-grade inflammation in humans. Roux-en-Y gastric bypass (RYGB) surgery is one of the most efficient procedures for the treatment of morbid obesity resulting in drastic weight loss and improvement of metabolic and inflammatory status. We analyzed the impact of RYGB on the modifications of gut microbiota and examined links with adaptations associated with this procedure.
Gut microbiota was profiled from fecal samples by real-time quantitative PCR in 13 lean control subjects and in 30 obese individuals (with seven type 2 diabetics) explored before (M0), 3 months (M3), and 6 months (M6) after RYGB.
Four major findings are highlighted: 1) Bacteroides/Prevotella group was lower in obese subjects than in control subjects at M0 and increased at M3. It was negatively correlated with corpulence, but the correlation depended highly on caloric intake; 2) Escherichia coli species increased at M3 and inversely correlated with fat mass and leptin levels independently of changes in food intake; 3) lactic acid bacteria including Lactobacillus/Leuconostoc/Pediococcus group and Bifidobacterium genus decreased at M3; and 4) Faecalibacterium prausnitzii species was lower in subjects with diabetes and associated negatively with inflammatory markers at M0 and throughout the follow-up after surgery independently of changes in food intake.
These results suggest that components of the dominant gut microbiota rapidly adapt in a starvation-like situation induced by RYGB while the F. prausnitzii species is directly linked to the reduction in low-grade inflammation state in obesity and diabetes independently of calorie intake.</description><subject>Adaptation, Physiological</subject><subject>Analysis</subject><subject>Bacteroides</subject><subject>Bacteroides - genetics</subject><subject>Bacteroides - isolation & purification</subject><subject>Bariatric Surgery</subject><subject>Bifidobacterium</subject><subject>Bifidobacterium - genetics</subject><subject>Bifidobacterium - isolation & purification</subject><subject>Biological and medical sciences</subject><subject>Blood Glucose - metabolism</subject><subject>Body composition</subject><subject>Body fat</subject><subject>Calories</subject><subject>Care and treatment</subject><subject>Clostridium - genetics</subject><subject>Clostridium - isolation & purification</subject><subject>Diabetes</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>DNA Primers</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Escherichia coli</subject><subject>Escherichia coli - isolation & purification</subject><subject>Etiopathogenesis. Screening. Investigations. Target tissue resistance</subject><subject>Faecalibacterium prausnitzii</subject><subject>Feces</subject><subject>Feces - microbiology</subject><subject>Female</subject><subject>Food</subject><subject>Gastrointestinal surgery</subject><subject>Glucose</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Inflammation - etiology</subject><subject>Inflammation - microbiology</subject><subject>Inflammation - physiopathology</subject><subject>Insulin</subject><subject>Lactobacillus</subject><subject>Lactobacillus - isolation & purification</subject><subject>Leptin</subject><subject>Leuconostoc</subject><subject>Leuconostoc - isolation & purification</subject><subject>Life Sciences</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metabolism</subject><subject>Microbiota</subject><subject>Microbiota (Symbiotic organisms)</subject><subject>Obesity</subject><subject>Obesity - microbiology</subject><subject>Obesity Studies</subject><subject>Patient outcomes</subject><subject>Pediococcus</subject><subject>Pediococcus - isolation & purification</subject><subject>Physiological aspects</subject><subject>Polymerase Chain Reaction</subject><subject>Prevotella</subject><subject>Research design</subject><subject>Starvation - microbiology</subject><subject>Surgery</subject><subject>Thinness - microbiology</subject><subject>Weight control</subject><subject>Weight loss</subject><subject>Weight Loss - physiology</subject><issn>0012-1797</issn><issn>1939-327X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkt9u0zAUxiMEYmNwwQsgC4TQLjIcO7HjXSCVAm2lVLsANO4ix3ZSb4ldbGewx-CNcdXyp1MF9oUtn9_3-fgcJ8nTDJ4hjOlr2WQwhajA95LjjGGWYkS_3E-OIcxQmlFGj5JH3l9BCEmcD5MjBEtKaMaOkx_vdNsqp0zQvAcTydeBB20NsC2YjwM3YDYGsNTC2UbbwEGw4C13mgenBfg4uk6523Rh5CiUBJdKd6sAKuv9Oai0ufbgUocVWKrAG9tHBTcyhr-lM8elAgvT9nwYtjcuubtWzj9OHrS89-rJbj1JPn94_2k6T6uL2WI6qdKuIEVIc8FkwUkjEcUU4qzlmBKpypYRsdk3sQ6wbAjFJaMthhgXNIcM4SxvhBQ5PknebH3XYzMoKWIJHO_rtdMDd7e15brejxi9qjt7UyPGECVFNDjdGqzuyOaTqt6cQURIWebwJovsq91lzn4dlQ_1oL1Qfc-NsqOvWZETiAuC_0uWWVEUKMs3ns_vkFd2dCbWLEIlLuPYJPliC3W8V7U2rY1vERvLeoLyIqYXCxSp9ADVKaPiw61RrY7He_zZAT5OqQYtDgpO9wSRCep76PjoY7az6l_J7Fhh-151qo6fYHqxzz_7u5G_W_Hrk0fg5Q7gXvC-ddwI7f9wmOaEIYh_AtH1BjU</recordid><startdate>20101201</startdate><enddate>20101201</enddate><creator>FURET, Jean-Pierre</creator><creator>KONG, Ling-Chun</creator><creator>RIZKALLA, Salwa</creator><creator>CLEMENT, Karine</creator><creator>TAP, Julien</creator><creator>POITOU, Christine</creator><creator>BASDEVANT, Arnaud</creator><creator>BOUILLOT, Jean-Luc</creator><creator>MARIAT, Denis</creator><creator>CORTHIER, Gérard</creator><creator>DORE, Joël</creator><creator>HENEGAR, Corneliu</creator><general>American Diabetes Association</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>8GL</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M2P</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>S0X</scope><scope>7X8</scope><scope>7T7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>1XC</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-8998-5413</orcidid><orcidid>https://orcid.org/0000-0003-4619-6785</orcidid><orcidid>https://orcid.org/0000-0001-7769-6331</orcidid><orcidid>https://orcid.org/0000-0002-2489-3355</orcidid></search><sort><creationdate>20101201</creationdate><title>Differential Adaptation of Human Gut Microbiota to Bariatric Surgery-Induced Weight Loss: Links With Metabolic and Low-Grade Inflammation Markers</title><author>FURET, Jean-Pierre ; KONG, Ling-Chun ; RIZKALLA, Salwa ; CLEMENT, Karine ; TAP, Julien ; POITOU, Christine ; BASDEVANT, Arnaud ; BOUILLOT, Jean-Luc ; MARIAT, Denis ; CORTHIER, Gérard ; DORE, Joël ; HENEGAR, Corneliu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-g565t-4c9d5a6bd2737031fa376de8f96cfa37b93908b673897f3033574092314bcdc43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adaptation, Physiological</topic><topic>Analysis</topic><topic>Bacteroides</topic><topic>Bacteroides - genetics</topic><topic>Bacteroides - isolation & purification</topic><topic>Bariatric Surgery</topic><topic>Bifidobacterium</topic><topic>Bifidobacterium - genetics</topic><topic>Bifidobacterium - isolation & purification</topic><topic>Biological and medical sciences</topic><topic>Blood Glucose - metabolism</topic><topic>Body composition</topic><topic>Body fat</topic><topic>Calories</topic><topic>Care and treatment</topic><topic>Clostridium - genetics</topic><topic>Clostridium - isolation & purification</topic><topic>Diabetes</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>DNA Primers</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Escherichia coli</topic><topic>Escherichia coli - isolation & purification</topic><topic>Etiopathogenesis. Screening. Investigations. Target tissue resistance</topic><topic>Faecalibacterium prausnitzii</topic><topic>Feces</topic><topic>Feces - microbiology</topic><topic>Female</topic><topic>Food</topic><topic>Gastrointestinal surgery</topic><topic>Glucose</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Inflammation - etiology</topic><topic>Inflammation - microbiology</topic><topic>Inflammation - physiopathology</topic><topic>Insulin</topic><topic>Lactobacillus</topic><topic>Lactobacillus - isolation & purification</topic><topic>Leptin</topic><topic>Leuconostoc</topic><topic>Leuconostoc - isolation & purification</topic><topic>Life Sciences</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Metabolism</topic><topic>Microbiota</topic><topic>Microbiota (Symbiotic organisms)</topic><topic>Obesity</topic><topic>Obesity - microbiology</topic><topic>Obesity Studies</topic><topic>Patient outcomes</topic><topic>Pediococcus</topic><topic>Pediococcus - isolation & purification</topic><topic>Physiological aspects</topic><topic>Polymerase Chain Reaction</topic><topic>Prevotella</topic><topic>Research design</topic><topic>Starvation - microbiology</topic><topic>Surgery</topic><topic>Thinness - microbiology</topic><topic>Weight control</topic><topic>Weight loss</topic><topic>Weight Loss - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>FURET, Jean-Pierre</creatorcontrib><creatorcontrib>KONG, Ling-Chun</creatorcontrib><creatorcontrib>RIZKALLA, Salwa</creatorcontrib><creatorcontrib>CLEMENT, Karine</creatorcontrib><creatorcontrib>TAP, Julien</creatorcontrib><creatorcontrib>POITOU, Christine</creatorcontrib><creatorcontrib>BASDEVANT, Arnaud</creatorcontrib><creatorcontrib>BOUILLOT, Jean-Luc</creatorcontrib><creatorcontrib>MARIAT, Denis</creatorcontrib><creatorcontrib>CORTHIER, Gérard</creatorcontrib><creatorcontrib>DORE, Joël</creatorcontrib><creatorcontrib>HENEGAR, Corneliu</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Gale In Context: High School</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>eLibrary</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>SIRS Editorial</collection><collection>MEDLINE - Academic</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Diabetes (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>FURET, Jean-Pierre</au><au>KONG, Ling-Chun</au><au>RIZKALLA, Salwa</au><au>CLEMENT, Karine</au><au>TAP, Julien</au><au>POITOU, Christine</au><au>BASDEVANT, Arnaud</au><au>BOUILLOT, Jean-Luc</au><au>MARIAT, Denis</au><au>CORTHIER, Gérard</au><au>DORE, Joël</au><au>HENEGAR, Corneliu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Differential Adaptation of Human Gut Microbiota to Bariatric Surgery-Induced Weight Loss: Links With Metabolic and Low-Grade Inflammation Markers</atitle><jtitle>Diabetes (New York, N.Y.)</jtitle><addtitle>Diabetes</addtitle><date>2010-12-01</date><risdate>2010</risdate><volume>59</volume><issue>12</issue><spage>3049</spage><epage>3057</epage><pages>3049-3057</pages><issn>0012-1797</issn><eissn>1939-327X</eissn><coden>DIAEAZ</coden><abstract>Obesity alters gut microbiota ecology and associates with low-grade inflammation in humans. Roux-en-Y gastric bypass (RYGB) surgery is one of the most efficient procedures for the treatment of morbid obesity resulting in drastic weight loss and improvement of metabolic and inflammatory status. We analyzed the impact of RYGB on the modifications of gut microbiota and examined links with adaptations associated with this procedure.
Gut microbiota was profiled from fecal samples by real-time quantitative PCR in 13 lean control subjects and in 30 obese individuals (with seven type 2 diabetics) explored before (M0), 3 months (M3), and 6 months (M6) after RYGB.
Four major findings are highlighted: 1) Bacteroides/Prevotella group was lower in obese subjects than in control subjects at M0 and increased at M3. It was negatively correlated with corpulence, but the correlation depended highly on caloric intake; 2) Escherichia coli species increased at M3 and inversely correlated with fat mass and leptin levels independently of changes in food intake; 3) lactic acid bacteria including Lactobacillus/Leuconostoc/Pediococcus group and Bifidobacterium genus decreased at M3; and 4) Faecalibacterium prausnitzii species was lower in subjects with diabetes and associated negatively with inflammatory markers at M0 and throughout the follow-up after surgery independently of changes in food intake.
These results suggest that components of the dominant gut microbiota rapidly adapt in a starvation-like situation induced by RYGB while the F. prausnitzii species is directly linked to the reduction in low-grade inflammation state in obesity and diabetes independently of calorie intake.</abstract><cop>Alexandria, VA</cop><pub>American Diabetes Association</pub><pmid>20876719</pmid><doi>10.2337/db10-0253</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-8998-5413</orcidid><orcidid>https://orcid.org/0000-0003-4619-6785</orcidid><orcidid>https://orcid.org/0000-0001-7769-6331</orcidid><orcidid>https://orcid.org/0000-0002-2489-3355</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0012-1797 |
| ispartof | Diabetes (New York, N.Y.), 2010-12, Vol.59 (12), p.3049-3057 |
| issn | 0012-1797 1939-327X |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2992765 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Adaptation, Physiological Analysis Bacteroides Bacteroides - genetics Bacteroides - isolation & purification Bariatric Surgery Bifidobacterium Bifidobacterium - genetics Bifidobacterium - isolation & purification Biological and medical sciences Blood Glucose - metabolism Body composition Body fat Calories Care and treatment Clostridium - genetics Clostridium - isolation & purification Diabetes Diabetes. Impaired glucose tolerance DNA Primers Endocrine pancreas. Apud cells (diseases) Endocrinopathies Escherichia coli Escherichia coli - isolation & purification Etiopathogenesis. Screening. Investigations. Target tissue resistance Faecalibacterium prausnitzii Feces Feces - microbiology Female Food Gastrointestinal surgery Glucose Humans Inflammation Inflammation - etiology Inflammation - microbiology Inflammation - physiopathology Insulin Lactobacillus Lactobacillus - isolation & purification Leptin Leuconostoc Leuconostoc - isolation & purification Life Sciences Male Medical sciences Metabolism Microbiota Microbiota (Symbiotic organisms) Obesity Obesity - microbiology Obesity Studies Patient outcomes Pediococcus Pediococcus - isolation & purification Physiological aspects Polymerase Chain Reaction Prevotella Research design Starvation - microbiology Surgery Thinness - microbiology Weight control Weight loss Weight Loss - physiology |
| title | Differential Adaptation of Human Gut Microbiota to Bariatric Surgery-Induced Weight Loss: Links With Metabolic and Low-Grade Inflammation Markers |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-27T17%3A34%3A37IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Differential%20Adaptation%20of%20Human%20Gut%20Microbiota%20to%20Bariatric%20Surgery-Induced%20Weight%20Loss:%20Links%20With%20Metabolic%20and%20Low-Grade%20Inflammation%20Markers&rft.jtitle=Diabetes%20(New%20York,%20N.Y.)&rft.au=FURET,%20Jean-Pierre&rft.date=2010-12-01&rft.volume=59&rft.issue=12&rft.spage=3049&rft.epage=3057&rft.pages=3049-3057&rft.issn=0012-1797&rft.eissn=1939-327X&rft.coden=DIAEAZ&rft_id=info:doi/10.2337/db10-0253&rft_dat=%3Cgale_pubme%3EA245884738%3C/gale_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=818388885&rft_id=info:pmid/20876719&rft_galeid=A245884738&rfr_iscdi=true |