Cell–Matrix Interactions Improve β-Cell Survival and Insulin Secretion in Three-Dimensional Culture

Controlled matrix interactions were presented to pancreatic β-cells in three-dimensional culture within poly(ethylene glycol) hydrogels. Dispersed MIN6 β-cells were encapsulated in gel environments containing the following entrapped extracellular matrix (ECM) proteins: collagen type I, collagen type...

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Veröffentlicht in:	Tissue engineering. Part A 2008-12, Vol.14 (12), p.1959-1968
Hauptverfasser:	Weber, Laney M., Hayda, Kirsten N., Anseth, Kristi S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - drug effects Cell Communication - drug effects Cell Culture Techniques - methods Cell Survival - drug effects Diabetes Extracellular matrix Extracellular Matrix - drug effects Extracellular Matrix - metabolism Extracellular Matrix Proteins - chemistry Extracellular Matrix Proteins - metabolism Glucose - pharmacology Hydrogel, Polyethylene Glycol Dimethacrylate - metabolism Insulin - metabolism Insulin Secretion Insulin-Secreting Cells - cytology Insulin-Secreting Cells - drug effects Insulin-Secreting Cells - metabolism Mice Pancreatic beta cells Physiological aspects Polyethylene Glycols - metabolism Receptors, Cell Surface - metabolism Structure Three-dimensional display systems
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