Rapamycin Inhibits Cytoskeleton Reorganization and Cell Motility by Suppressing RhoA Expression and Activity

The mammalian target of rapamycin (mTOR) functions in cells at least as two complexes, mTORC1 and mTORC2. Intensive studies have focused on the roles of mTOR in the regulation of cell proliferation, growth, and survival. Recently we found that rapamycin inhibits type I insulin-like growth factor (IG...

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Veröffentlicht in:	The Journal of biological chemistry 2010-12, Vol.285 (49), p.38362-38373
Hauptverfasser:	Liu, Lei, Luo, Yan, Chen, Long, Shen, Tao, Xu, Baoshan, Chen, Wenxing, Zhou, Hongyu, Han, Xiuzhen, Huang, Shile
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Antibiotics, Antineoplastic - pharmacology cdc42 GTP-Binding Protein - genetics cdc42 GTP-Binding Protein - metabolism Cell Cycle Proteins Cell Motility Cell Movement - drug effects Cell Movement - physiology Cell Survival - drug effects Cell Survival - physiology Cytoskeleton Cytoskeleton - genetics Cytoskeleton - metabolism Gene Expression Regulation - drug effects Gene Expression Regulation - physiology HeLa Cells Humans Insulin-Like Growth Factor I - genetics Insulin-Like Growth Factor I - metabolism Mechanistic Target of Rapamycin Complex 1 mTOR Multiprotein Complexes Phosphoproteins - genetics Phosphoproteins - metabolism Phosphorylation - drug effects Phosphorylation - physiology Protein Biosynthesis - drug effects Protein Biosynthesis - physiology Protein Synthesis Proteins - genetics Proteins - metabolism rac1 GTP-Binding Protein - genetics rac1 GTP-Binding Protein - metabolism Rho rhoA GTP-Binding Protein - genetics rhoA GTP-Binding Protein - metabolism Ribosomal Protein S6 Kinases, 70-kDa - genetics Ribosomal Protein S6 Kinases, 70-kDa - metabolism Signal Transduction Signal Transduction - drug effects Signal Transduction - physiology Sirolimus - pharmacology TOR Serine-Threonine Kinases Transcription Factors - genetics Transcription Factors - metabolism
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