Type 2 diabetes in mice induces hepatic overexpression of sulfatase 2, a novel factor that suppresses uptake of remnant lipoproteins

Type 2 diabetes mellitus (T2DM) impairs hepatic clearance of atherogenic postprandial remnant lipoproteins. Our work and that of others have identified syndecan‐1 heparan sulfate proteoglycans (HSPGs) as remnant lipoprotein receptors. Nevertheless, defects in the T2DM liver have not been molecularly...

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Veröffentlicht in:	Hepatology (Baltimore, Md.) Md.), 2010-12, Vol.52 (6), p.1957-1967
Hauptverfasser:	Chen, Keyang, Liu, Ming‐Lin, Schaffer, Lana, Li, Mingzhen, Boden, Guenther, Wu, Xiangdong, Williams, Kevin Jon
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Caloric Restriction Cholesterol Diabetes Diabetes Mellitus, Type 2 - metabolism Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Gastroenterology. Liver. Pancreas. Abdomen Glycation End Products, Advanced - physiology Heparan sulfate Heparan Sulfate Proteoglycans - metabolism Hepatocytes - metabolism Hepatology Lipoproteins Lipoproteins - metabolism Liver - enzymology Liver - metabolism Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Medical sciences Mice Rats Rodents Sulfatases - biosynthesis Up-Regulation
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