Myosin light chain mono- and di-phosphorylation differentially regulate adhesion and polarity in migrating cells

► Adhesion to fibronectin via the α5β1 integrin promotes mono- and di-phosphorylation of the RLC. ► Mono- and di-phosphorylated RLC form with different kinetics and have distinct subcellular distributions. ► Mono-phosphomimetic RLC induces adhesion maturation throughout the cell; di-phosphomimetic R...

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Veröffentlicht in:	Biochemical and biophysical research communications 2010-11, Vol.402 (3), p.537-542
Hauptverfasser:	Vicente-Manzanares, Miguel, Horwitz, Alan Rick
Format:	Artikel
Sprache:	eng
Schlagworte:	Adhesion Animals Cell Adhesion Cell migration Cell Movement Cell Polarity CHO Cells Cricetinae Cricetulus Myosin II Myosin Light Chains - metabolism Myosin Type II - metabolism Phosphorylation Polarity
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