CD200R1 regulates the severity of arthritis but has minimal impact on the adaptive immune response

CD200R1 is a member of the immunoglobulin supergene family that is thought to play an inhibitory role in immunity. Previous studies have established the anti-arthritic effect of CD200Fc, an agonist of CD200R1. However, the physiological role played by CD200R1 in arthritis remains to be established....

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Veröffentlicht in:	Clinical and experimental immunology 2010-10, Vol.162 (1), p.163-168
Hauptverfasser:	Šimelyte, E, Alzabin, S, Boudakov, I, Williams, R
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptive Immunity - immunology Analytical, structural and metabolic biochemistry Animal models Animal Studies Animals Antigens, CD - genetics Antigens, CD - immunology Antigens, CD - metabolism Antigens, Surface - genetics Antigens, Surface - immunology Antigens, Surface - metabolism Arthritis Arthritis, Experimental - immunology Arthritis, Experimental - metabolism Arthritis, Experimental - pathology Biological and medical sciences CD200 CD200 antigen Cell Proliferation Cells, Cultured Collagen Collagen (type II) collagen-induced arthritis Cytokines - metabolism Diseases of the osteoarticular system Female Flow Cytometry Fundamental and applied biological sciences. Psychology Gene Expression Profiling Immune response Immunity Immunization Immunoglobulins immunoregulation Inflammation Inflammatory joint diseases Kinetics Lymphocytes B Lymphocytes T Male Medical research Medical sciences Mice Mice, Inbred C57BL Mice, Inbred DBA Mice, Knockout Orexin Receptors Receptors, Cell Surface - genetics Receptors, Cell Surface - immunology Receptors, Cell Surface - metabolism Reverse Transcriptase Polymerase Chain Reaction Rheumatoid arthritis Rodents Severity of Illness Index Signal Transduction - immunology T-Lymphocytes - cytology T-Lymphocytes - immunology T-Lymphocytes - metabolism
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