CD23/FcεRII: molecular multi-tasking
CD23 is the low-affinity receptor for immunoglobulin (Ig)E and plays important roles in the regulation of IgE responses. CD23 can be cleaved from cell surfaces to yield a range of soluble CD23 (sCD23) proteins that have pleiotropic cytokine-like activities. The regions of CD23 responsible for intera...
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| Veröffentlicht in: | Clinical and experimental immunology 2010-10, Vol.162 (1), p.12-23 |
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| container_title | Clinical and experimental immunology |
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| creator | Acharya, M Borland, G Edkins, A.L MacLellan, L.M Matheson, J Ozanne, B.W Cushley, W |
| description | CD23 is the low-affinity receptor for immunoglobulin (Ig)E and plays important roles in the regulation of IgE responses. CD23 can be cleaved from cell surfaces to yield a range of soluble CD23 (sCD23) proteins that have pleiotropic cytokine-like activities. The regions of CD23 responsible for interaction with many of its known ligands, including IgE, CD21, major histocompatibility complex (MHC) class II and integrins, have been identified and help to explain the structure-function relationships within the CD23 protein. Translational studies of CD23 underline its credibility as a target for therapeutic intervention strategies and illustrate its involvement in mediating therapeutic effects of antibodies directed at other targets. |
| doi_str_mv | 10.1111/j.1365-2249.2010.04210.x |
| format | Article |
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CD23 can be cleaved from cell surfaces to yield a range of soluble CD23 (sCD23) proteins that have pleiotropic cytokine-like activities. The regions of CD23 responsible for interaction with many of its known ligands, including IgE, CD21, major histocompatibility complex (MHC) class II and integrins, have been identified and help to explain the structure-function relationships within the CD23 protein. 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Psychology ; Humans ; IgE ; immunoregulation ; integrins ; Ligands ; Models, Molecular ; Molecular Sequence Data ; Protein Binding ; Protein Structure, Secondary ; Protein Structure, Tertiary ; Receptors, IgE - chemistry ; Receptors, IgE - genetics ; Receptors, IgE - metabolism ; Review</subject><ispartof>Clinical and experimental immunology, 2010-10, Vol.162 (1), p.12-23</ispartof><rights>2010 The Authors. Clinical and Experimental Immunology © 2010 British Society for Immunology</rights><rights>2015 INIST-CNRS</rights><rights>2010 The Authors. 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CD23 can be cleaved from cell surfaces to yield a range of soluble CD23 (sCD23) proteins that have pleiotropic cytokine-like activities. The regions of CD23 responsible for interaction with many of its known ligands, including IgE, CD21, major histocompatibility complex (MHC) class II and integrins, have been identified and help to explain the structure-function relationships within the CD23 protein. Translational studies of CD23 underline its credibility as a target for therapeutic intervention strategies and illustrate its involvement in mediating therapeutic effects of antibodies directed at other targets.</description><subject>Amino Acid Sequence</subject><subject>Analytical, structural and metabolic biochemistry</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>CD23</subject><subject>cytokines</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>IgE</subject><subject>immunoregulation</subject><subject>integrins</subject><subject>Ligands</subject><subject>Models, Molecular</subject><subject>Molecular Sequence Data</subject><subject>Protein Binding</subject><subject>Protein Structure, Secondary</subject><subject>Protein Structure, Tertiary</subject><subject>Receptors, IgE - chemistry</subject><subject>Receptors, IgE - genetics</subject><subject>Receptors, IgE - metabolism</subject><subject>Review</subject><issn>0009-9104</issn><issn>1365-2249</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkMlOwzAQhi0EgrK8AvSCOKV4jWMkkFDZKlVCYjlbtuuUFCcBu2F5MF6DZ8JpS4Ebc7DHnu-fGf0AdBHsoRiHkx4iKUswpqKHYfyFFMfzbQV0loVV0IEQikQgSDfAZgiT-EzTFK-DDQwzgjjCHbDfP8Pk8MJ8ftwMBkfdsnbWNE75btm4aZFMVXgsqvE2WMuVC3ZncW-B-4vzu_5VMry-HPRPh4lhmMNEI6U05lozRhRBRmRW4IwYLqimesRTrVGeC85GSNmRTbHlKcOCU0tjCEG2wMm871OjSzsytpp65eSTL0rl32WtCvm3UhUPcly_SCwEFJjFBgeLBr5-bmyYyrIIxjqnKls3QXJGowkia8lsThpfh-BtvpyCoGxNlhPZeilbL2VrspyZLN-idPf3lkvht6sR2F8AKhjlcq8qU4QfjuCIzXY4nnOvhbPv_15A9s8HbRb1e3N9rmqpxj7OuL-NJIEoy1LEKPkC8UCfyQ</recordid><startdate>201010</startdate><enddate>201010</enddate><creator>Acharya, M</creator><creator>Borland, G</creator><creator>Edkins, A.L</creator><creator>MacLellan, L.M</creator><creator>Matheson, J</creator><creator>Ozanne, B.W</creator><creator>Cushley, W</creator><general>Oxford, UK : Blackwell Publishing Ltd</general><general>Blackwell Publishing Ltd</general><general>Blackwell</general><general>Blackwell Science Inc</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201010</creationdate><title>CD23/FcεRII: molecular multi-tasking</title><author>Acharya, M ; Borland, G ; Edkins, A.L ; MacLellan, L.M ; Matheson, J ; Ozanne, B.W ; Cushley, W</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5270-b1aab27bb553a31c98e9283c794b4bd76bb1ff975d1aede62e7652974e4444993</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Amino Acid Sequence</topic><topic>Analytical, structural and metabolic biochemistry</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>CD23</topic><topic>cytokines</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>IgE</topic><topic>immunoregulation</topic><topic>integrins</topic><topic>Ligands</topic><topic>Models, Molecular</topic><topic>Molecular Sequence Data</topic><topic>Protein Binding</topic><topic>Protein Structure, Secondary</topic><topic>Protein Structure, Tertiary</topic><topic>Receptors, IgE - chemistry</topic><topic>Receptors, IgE - genetics</topic><topic>Receptors, IgE - metabolism</topic><topic>Review</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Acharya, M</creatorcontrib><creatorcontrib>Borland, G</creatorcontrib><creatorcontrib>Edkins, A.L</creatorcontrib><creatorcontrib>MacLellan, L.M</creatorcontrib><creatorcontrib>Matheson, J</creatorcontrib><creatorcontrib>Ozanne, B.W</creatorcontrib><creatorcontrib>Cushley, W</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Clinical and experimental immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Acharya, M</au><au>Borland, G</au><au>Edkins, A.L</au><au>MacLellan, L.M</au><au>Matheson, J</au><au>Ozanne, B.W</au><au>Cushley, W</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>CD23/FcεRII: molecular multi-tasking</atitle><jtitle>Clinical and experimental immunology</jtitle><addtitle>Clin Exp Immunol</addtitle><date>2010-10</date><risdate>2010</risdate><volume>162</volume><issue>1</issue><spage>12</spage><epage>23</epage><pages>12-23</pages><issn>0009-9104</issn><eissn>1365-2249</eissn><coden>CEXIAL</coden><abstract>CD23 is the low-affinity receptor for immunoglobulin (Ig)E and plays important roles in the regulation of IgE responses. CD23 can be cleaved from cell surfaces to yield a range of soluble CD23 (sCD23) proteins that have pleiotropic cytokine-like activities. The regions of CD23 responsible for interaction with many of its known ligands, including IgE, CD21, major histocompatibility complex (MHC) class II and integrins, have been identified and help to explain the structure-function relationships within the CD23 protein. Translational studies of CD23 underline its credibility as a target for therapeutic intervention strategies and illustrate its involvement in mediating therapeutic effects of antibodies directed at other targets.</abstract><cop>Oxford, UK</cop><pub>Oxford, UK : Blackwell Publishing Ltd</pub><pmid>20831712</pmid><doi>10.1111/j.1365-2249.2010.04210.x</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Oxford University Press Journals All Titles (1996-Current); PubMed Central; Alma/SFX Local Collection |
| subjects | Amino Acid Sequence Analytical, structural and metabolic biochemistry Animals Biological and medical sciences CD23 cytokines Fundamental and applied biological sciences. Psychology Humans IgE immunoregulation integrins Ligands Models, Molecular Molecular Sequence Data Protein Binding Protein Structure, Secondary Protein Structure, Tertiary Receptors, IgE - chemistry Receptors, IgE - genetics Receptors, IgE - metabolism Review |
| title | CD23/FcεRII: molecular multi-tasking |
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