Reduced Skeletal Muscle Capillarization and Glucose Intolerance
Objective: Reduced capillarization in hemiparetic skeletal muscle of chronic stroke patients can limit insulin, glucose, and oxygen supply to muscle, thereby contributing to impaired glucose metabolism and cardiovascular deconditioning. We hypothesized that compared to sedentary controls, stroke sub...
Gespeichert in:
| Veröffentlicht in: | Microcirculation (New York, N.Y. 1994) N.Y. 1994), 2009-04, Vol.16 (3), p.203-212 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 212 |
|---|---|
| container_issue | 3 |
| container_start_page | 203 |
| container_title | Microcirculation (New York, N.Y. 1994) |
| container_volume | 16 |
| creator | Prior, Steven J. Mckenzie, Michael J. Joseph, Lyndon J. Ivey, Frederick M. Macko, Richard F. Hafer-Macko, Charlene E. Ryan, Alice S. |
| description | Objective: Reduced capillarization in hemiparetic skeletal muscle of chronic stroke patients can limit insulin, glucose, and oxygen supply to muscle, thereby contributing to impaired glucose metabolism and cardiovascular deconditioning. We hypothesized that compared to sedentary controls, stroke subjects have reduced skeletal muscle capillarization that is associated with glucose intolerance and reduced peak oxygen consumption (Vo2peak). Methods: Twelve chronic stroke subjects (ages, 62.1±2.8 years), and matched sedentary controls with impaired (n=12) or normal (n=12) glucose tolerance underwent oral glucose tolerance tests, exercise tests, and vastus lateralis biopsies. Results: Stroke subjects had lower capillarization in hemiparetic muscle than in nonparetic muscle and normal glucose tolerant controls (∼22 and ∼28%, respectively; P |
| doi_str_mv | 10.1080/10739680802502423 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2990692</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>66999643</sourcerecordid><originalsourceid>FETCH-LOGICAL-c6001-e32739e96d01a0086b913aefc5dd59dcb0a101f2fb085c58093b38f968b0d95f3</originalsourceid><addsrcrecordid>eNqFkV9rFDEUxYNYbLv6AXyRefJtNH822QRBKYNdF7YKVem-hUzmjps2m6zJjLV--qbsUiuCPuVCfufk3BOEnhP8imCJXxM8Y0rIMlKO6ZSyR-iI8Kmq5Yyox2Uu93UB5CE6zvkSYywlVU_QIVGUciX5EXp3Dt1ooas-X4GHwfjqbMzWQ9WYrfPeJPfLDC6GyoSumvvRxgzVIgzRQzLBwlN00Buf4dn-nKCvp--_NB_q5af5ojlZ1lZgTGpgtEQFJTpMTIkhWkWYgd7yruOqsy02BJOe9i2W3HKJFWuZ7Ev2FneK92yC3u58t2O7gc5CGJLxepvcxqQbHY3Tf94Et9bf4g9NlcJC0WLwcm-Q4vcR8qA3LlsoKwaIY9ZCKKXElBWQ7ECbYs4J-vtHCNZ3teu_ai-aFw_T_Vbsey6A2AHXzsPN_x312aJpROloguqd0OUBft4LTbrSYsZmXF98nOvVxUotV6dLfV74N3s-9DFtzBqMH9bWJNCXcUyh_NE_9rgFy0KvOg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>66999643</pqid></control><display><type>article</type><title>Reduced Skeletal Muscle Capillarization and Glucose Intolerance</title><source>Taylor & Francis</source><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Prior, Steven J. ; Mckenzie, Michael J. ; Joseph, Lyndon J. ; Ivey, Frederick M. ; Macko, Richard F. ; Hafer-Macko, Charlene E. ; Ryan, Alice S.</creator><creatorcontrib>Prior, Steven J. ; Mckenzie, Michael J. ; Joseph, Lyndon J. ; Ivey, Frederick M. ; Macko, Richard F. ; Hafer-Macko, Charlene E. ; Ryan, Alice S.</creatorcontrib><description>Objective: Reduced capillarization in hemiparetic skeletal muscle of chronic stroke patients can limit insulin, glucose, and oxygen supply to muscle, thereby contributing to impaired glucose metabolism and cardiovascular deconditioning. We hypothesized that compared to sedentary controls, stroke subjects have reduced skeletal muscle capillarization that is associated with glucose intolerance and reduced peak oxygen consumption (Vo2peak). Methods: Twelve chronic stroke subjects (ages, 62.1±2.8 years), and matched sedentary controls with impaired (n=12) or normal (n=12) glucose tolerance underwent oral glucose tolerance tests, exercise tests, and vastus lateralis biopsies. Results: Stroke subjects had lower capillarization in hemiparetic muscle than in nonparetic muscle and normal glucose tolerant controls (∼22 and ∼28%, respectively; P<0.05) and had similar bilateral capillarization, compared to controls with impaired glucose tolerance. Capillary density in hemiparetic muscle inversely correlated with 120-minute glucose (r=−0.70, P<0.01) and glucose area under the curve (r=−0.78, P<0.01). Vo2peak was ∼40% lower in stroke subjects, compared to controls (P<0.001), but did not correlate with capillarization (P=n.s.). Conclusions: Hemiparetic muscle capillarization is reduced after stroke, and reduced capillarization is associated with glucose intolerance in stroke and control subjects. Interventions to increase skeletal muscle capillarization may prove beneficial for improving glucose metabolism in chronic stroke patients.</description><identifier>ISSN: 1073-9688</identifier><identifier>EISSN: 1549-8719</identifier><identifier>DOI: 10.1080/10739680802502423</identifier><identifier>PMID: 19225985</identifier><language>eng</language><publisher>Oxford, UK: Informa UK Ltd</publisher><subject>capillaries ; Capillaries - physiopathology ; Case-Control Studies ; diabetes ; Female ; Glucose Intolerance ; hemiparesis ; Humans ; insulin resistance ; Male ; Middle Aged ; Muscle, Skeletal - blood supply ; Oxygen Consumption ; Paresis ; Quadriceps Muscle - blood supply ; skeletal muscle ; Stroke - metabolism ; Stroke - physiopathology</subject><ispartof>Microcirculation (New York, N.Y. 1994), 2009-04, Vol.16 (3), p.203-212</ispartof><rights>2009 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 2009</rights><rights>2009 Blackwell</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c6001-e32739e96d01a0086b913aefc5dd59dcb0a101f2fb085c58093b38f968b0d95f3</citedby><cites>FETCH-LOGICAL-c6001-e32739e96d01a0086b913aefc5dd59dcb0a101f2fb085c58093b38f968b0d95f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1080/10739680802502423$$EPDF$$P50$$Ginformahealthcare$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1080/10739680802502423$$EHTML$$P50$$Ginformahealthcare$$H</linktohtml><link.rule.ids>230,314,776,780,881,1411,27901,27902,45550,45551,61194,61375</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19225985$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Prior, Steven J.</creatorcontrib><creatorcontrib>Mckenzie, Michael J.</creatorcontrib><creatorcontrib>Joseph, Lyndon J.</creatorcontrib><creatorcontrib>Ivey, Frederick M.</creatorcontrib><creatorcontrib>Macko, Richard F.</creatorcontrib><creatorcontrib>Hafer-Macko, Charlene E.</creatorcontrib><creatorcontrib>Ryan, Alice S.</creatorcontrib><title>Reduced Skeletal Muscle Capillarization and Glucose Intolerance</title><title>Microcirculation (New York, N.Y. 1994)</title><addtitle>Microcirculation</addtitle><description>Objective: Reduced capillarization in hemiparetic skeletal muscle of chronic stroke patients can limit insulin, glucose, and oxygen supply to muscle, thereby contributing to impaired glucose metabolism and cardiovascular deconditioning. We hypothesized that compared to sedentary controls, stroke subjects have reduced skeletal muscle capillarization that is associated with glucose intolerance and reduced peak oxygen consumption (Vo2peak). Methods: Twelve chronic stroke subjects (ages, 62.1±2.8 years), and matched sedentary controls with impaired (n=12) or normal (n=12) glucose tolerance underwent oral glucose tolerance tests, exercise tests, and vastus lateralis biopsies. Results: Stroke subjects had lower capillarization in hemiparetic muscle than in nonparetic muscle and normal glucose tolerant controls (∼22 and ∼28%, respectively; P<0.05) and had similar bilateral capillarization, compared to controls with impaired glucose tolerance. Capillary density in hemiparetic muscle inversely correlated with 120-minute glucose (r=−0.70, P<0.01) and glucose area under the curve (r=−0.78, P<0.01). Vo2peak was ∼40% lower in stroke subjects, compared to controls (P<0.001), but did not correlate with capillarization (P=n.s.). Conclusions: Hemiparetic muscle capillarization is reduced after stroke, and reduced capillarization is associated with glucose intolerance in stroke and control subjects. Interventions to increase skeletal muscle capillarization may prove beneficial for improving glucose metabolism in chronic stroke patients.</description><subject>capillaries</subject><subject>Capillaries - physiopathology</subject><subject>Case-Control Studies</subject><subject>diabetes</subject><subject>Female</subject><subject>Glucose Intolerance</subject><subject>hemiparesis</subject><subject>Humans</subject><subject>insulin resistance</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Muscle, Skeletal - blood supply</subject><subject>Oxygen Consumption</subject><subject>Paresis</subject><subject>Quadriceps Muscle - blood supply</subject><subject>skeletal muscle</subject><subject>Stroke - metabolism</subject><subject>Stroke - physiopathology</subject><issn>1073-9688</issn><issn>1549-8719</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkV9rFDEUxYNYbLv6AXyRefJtNH822QRBKYNdF7YKVem-hUzmjps2m6zJjLV--qbsUiuCPuVCfufk3BOEnhP8imCJXxM8Y0rIMlKO6ZSyR-iI8Kmq5Yyox2Uu93UB5CE6zvkSYywlVU_QIVGUciX5EXp3Dt1ooas-X4GHwfjqbMzWQ9WYrfPeJPfLDC6GyoSumvvRxgzVIgzRQzLBwlN00Buf4dn-nKCvp--_NB_q5af5ojlZ1lZgTGpgtEQFJTpMTIkhWkWYgd7yruOqsy02BJOe9i2W3HKJFWuZ7Ev2FneK92yC3u58t2O7gc5CGJLxepvcxqQbHY3Tf94Et9bf4g9NlcJC0WLwcm-Q4vcR8qA3LlsoKwaIY9ZCKKXElBWQ7ECbYs4J-vtHCNZ3teu_ai-aFw_T_Vbsey6A2AHXzsPN_x312aJpROloguqd0OUBft4LTbrSYsZmXF98nOvVxUotV6dLfV74N3s-9DFtzBqMH9bWJNCXcUyh_NE_9rgFy0KvOg</recordid><startdate>200904</startdate><enddate>200904</enddate><creator>Prior, Steven J.</creator><creator>Mckenzie, Michael J.</creator><creator>Joseph, Lyndon J.</creator><creator>Ivey, Frederick M.</creator><creator>Macko, Richard F.</creator><creator>Hafer-Macko, Charlene E.</creator><creator>Ryan, Alice S.</creator><general>Informa UK Ltd</general><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>200904</creationdate><title>Reduced Skeletal Muscle Capillarization and Glucose Intolerance</title><author>Prior, Steven J. ; Mckenzie, Michael J. ; Joseph, Lyndon J. ; Ivey, Frederick M. ; Macko, Richard F. ; Hafer-Macko, Charlene E. ; Ryan, Alice S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c6001-e32739e96d01a0086b913aefc5dd59dcb0a101f2fb085c58093b38f968b0d95f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>capillaries</topic><topic>Capillaries - physiopathology</topic><topic>Case-Control Studies</topic><topic>diabetes</topic><topic>Female</topic><topic>Glucose Intolerance</topic><topic>hemiparesis</topic><topic>Humans</topic><topic>insulin resistance</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Muscle, Skeletal - blood supply</topic><topic>Oxygen Consumption</topic><topic>Paresis</topic><topic>Quadriceps Muscle - blood supply</topic><topic>skeletal muscle</topic><topic>Stroke - metabolism</topic><topic>Stroke - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Prior, Steven J.</creatorcontrib><creatorcontrib>Mckenzie, Michael J.</creatorcontrib><creatorcontrib>Joseph, Lyndon J.</creatorcontrib><creatorcontrib>Ivey, Frederick M.</creatorcontrib><creatorcontrib>Macko, Richard F.</creatorcontrib><creatorcontrib>Hafer-Macko, Charlene E.</creatorcontrib><creatorcontrib>Ryan, Alice S.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Microcirculation (New York, N.Y. 1994)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Prior, Steven J.</au><au>Mckenzie, Michael J.</au><au>Joseph, Lyndon J.</au><au>Ivey, Frederick M.</au><au>Macko, Richard F.</au><au>Hafer-Macko, Charlene E.</au><au>Ryan, Alice S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Reduced Skeletal Muscle Capillarization and Glucose Intolerance</atitle><jtitle>Microcirculation (New York, N.Y. 1994)</jtitle><addtitle>Microcirculation</addtitle><date>2009-04</date><risdate>2009</risdate><volume>16</volume><issue>3</issue><spage>203</spage><epage>212</epage><pages>203-212</pages><issn>1073-9688</issn><eissn>1549-8719</eissn><abstract>Objective: Reduced capillarization in hemiparetic skeletal muscle of chronic stroke patients can limit insulin, glucose, and oxygen supply to muscle, thereby contributing to impaired glucose metabolism and cardiovascular deconditioning. We hypothesized that compared to sedentary controls, stroke subjects have reduced skeletal muscle capillarization that is associated with glucose intolerance and reduced peak oxygen consumption (Vo2peak). Methods: Twelve chronic stroke subjects (ages, 62.1±2.8 years), and matched sedentary controls with impaired (n=12) or normal (n=12) glucose tolerance underwent oral glucose tolerance tests, exercise tests, and vastus lateralis biopsies. Results: Stroke subjects had lower capillarization in hemiparetic muscle than in nonparetic muscle and normal glucose tolerant controls (∼22 and ∼28%, respectively; P<0.05) and had similar bilateral capillarization, compared to controls with impaired glucose tolerance. Capillary density in hemiparetic muscle inversely correlated with 120-minute glucose (r=−0.70, P<0.01) and glucose area under the curve (r=−0.78, P<0.01). Vo2peak was ∼40% lower in stroke subjects, compared to controls (P<0.001), but did not correlate with capillarization (P=n.s.). Conclusions: Hemiparetic muscle capillarization is reduced after stroke, and reduced capillarization is associated with glucose intolerance in stroke and control subjects. Interventions to increase skeletal muscle capillarization may prove beneficial for improving glucose metabolism in chronic stroke patients.</abstract><cop>Oxford, UK</cop><pub>Informa UK Ltd</pub><pmid>19225985</pmid><doi>10.1080/10739680802502423</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1073-9688 |
| ispartof | Microcirculation (New York, N.Y. 1994), 2009-04, Vol.16 (3), p.203-212 |
| issn | 1073-9688 1549-8719 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2990692 |
| source | Taylor & Francis; MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | capillaries Capillaries - physiopathology Case-Control Studies diabetes Female Glucose Intolerance hemiparesis Humans insulin resistance Male Middle Aged Muscle, Skeletal - blood supply Oxygen Consumption Paresis Quadriceps Muscle - blood supply skeletal muscle Stroke - metabolism Stroke - physiopathology |
| title | Reduced Skeletal Muscle Capillarization and Glucose Intolerance |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-21T15%3A23%3A30IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Reduced%20Skeletal%20Muscle%20Capillarization%20and%20Glucose%20Intolerance&rft.jtitle=Microcirculation%20(New%20York,%20N.Y.%201994)&rft.au=Prior,%20Steven%20J.&rft.date=2009-04&rft.volume=16&rft.issue=3&rft.spage=203&rft.epage=212&rft.pages=203-212&rft.issn=1073-9688&rft.eissn=1549-8719&rft_id=info:doi/10.1080/10739680802502423&rft_dat=%3Cproquest_pubme%3E66999643%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=66999643&rft_id=info:pmid/19225985&rfr_iscdi=true |