Vitamin K-dependent carboxylation of pulmonary surfactant-associated proteins
Rat type II pneumocytes expressed vitamin K-dependent carboxylase activity that incorporated 14CO2 into microsomal protein precursors of molecular weights similar to those of surfactant-associated proteins (SAP). Compared to carboxylated precursor proteins present in the liver, these molecules appea...
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| Veröffentlicht in: | Proc. Natl. Acad. Sci. U.S.A.; (United States) 1987-08, Vol.84 (16), p.5952-5956 |
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| creator | Rannels, S.R Gallaher, K.J Wallin, R Rannels, D.E |
| description | Rat type II pneumocytes expressed vitamin K-dependent carboxylase activity that incorporated 14CO2 into microsomal protein precursors of molecular weights similar to those of surfactant-associated proteins (SAP). Compared to carboxylated precursor proteins present in the liver, these molecules appeared to be unique to the lung. Antibodies raised against purified rat surfactant reacted with SAP resolved by NaDodSO4/PAGE and with surfactant-containing lamellar bodies in type II pneumocyte cytoplasm. NaDodSO4/PAGE of microsomal proteins, after carboxylase-catalyzed incorporation of 14CO2, demonstrated radiolabeled, immunoreactive products identical to SAP. The presence of γ -carboxyglutamic acid in these proteins was confirmed by HPLC analysis of SAP hydrolysates. Furthermore, lung carboxylase activity and SAP matured over similar time courses during fetal lung development. These results show that SAP are carboxylated by type II cells via a vitamin K-dependent pathway analogous to that for hepatic carboxylation of clotting factors. Further analogy to the clotting system suggests that γ -carboxyglutamic acid residues in SAP polypeptides play a role in Ca2+ binding and thus in the known requirements for both the cation and SAP in the physiological function of pulmonary surfactant. |
| doi_str_mv | 10.1073/pnas.84.16.5952 |
| format | Article |
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Compared to carboxylated precursor proteins present in the liver, these molecules appeared to be unique to the lung. Antibodies raised against purified rat surfactant reacted with SAP resolved by NaDodSO4/PAGE and with surfactant-containing lamellar bodies in type II pneumocyte cytoplasm. NaDodSO4/PAGE of microsomal proteins, after carboxylase-catalyzed incorporation of 14CO2, demonstrated radiolabeled, immunoreactive products identical to SAP. The presence of γ -carboxyglutamic acid in these proteins was confirmed by HPLC analysis of SAP hydrolysates. Furthermore, lung carboxylase activity and SAP matured over similar time courses during fetal lung development. These results show that SAP are carboxylated by type II cells via a vitamin K-dependent pathway analogous to that for hepatic carboxylation of clotting factors. Further analogy to the clotting system suggests that γ -carboxyglutamic acid residues in SAP polypeptides play a role in Ca2+ binding and thus in the known requirements for both the cation and SAP in the physiological function of pulmonary surfactant.</description><identifier>ISSN: 0027-8424</identifier><identifier>EISSN: 1091-6490</identifier><identifier>DOI: 10.1073/pnas.84.16.5952</identifier><identifier>PMID: 3475711</identifier><identifier>CODEN: PNASA6</identifier><language>eng</language><publisher>Washington, DC: National Academy of Sciences of the United States of America</publisher><subject>550201 - Biochemistry- Tracer Techniques ; ANIMAL CELLS ; ANIMALS ; Antibodies ; Applied sciences ; AROMATICS ; BASIC BIOLOGICAL SCIENCES ; BIOSYNTHESIS ; BODY ; Calcium - metabolism ; CARBON 14 COMPOUNDS ; CARBON COMPOUNDS ; CARBON DIOXIDE ; CARBON OXIDES ; CARBON-CARBON LYASES ; CARBOXY-LYASES ; CARBOXYLASE ; CARBOXYLATION ; CELL CONSTITUENTS ; Cells ; CHALCOGENIDES ; CHEMICAL REACTIONS ; Chromatography, High Pressure Liquid ; COAGULANTS ; DESARROLLO EMBRIONARIO ; DEVELOPPEMENT EMBRYONNAIRE ; DRUGS ; ELECTROPHORESIS ; Electrophoresis, Polyacrylamide Gel ; EMBRYONIC DEVELOPMENT ; ENZYME ACTIVITY ; ENZYMES ; Epithelial cells ; Exact sciences and technology ; HEMATOLOGIC AGENTS ; HEPARIN ANTAGONISTS ; IMMUNE SERUMS ; LABELLED COMPOUNDS ; LIASAS ; Liver ; Lung - enzymology ; Lung - growth & development ; LUNGS ; LYASE ; LYASES ; MAMMALS ; MICROSOMES ; Microsomes - metabolism ; MOLECULAR WEIGHT ; ORGANIC COMPOUNDS ; ORGANIC OXYGEN COMPOUNDS ; ORGANOIDS ; ORGANS ; Other techniques and industries ; OXIDES ; OXYGEN COMPOUNDS ; Pneumocytes ; POUMON ; PROTEINAS ; PROTEINE ; PROTEINS ; Proteolipids - metabolism ; Pulmonary Surfactant-Associated Proteins ; Pulmonary Surfactants - metabolism ; PULMONES ; QUINONES ; RAT ; RATA ; RATS ; RESPIRATORY SYSTEM ; RESPIRATORY TRACT CELLS ; RODENTS ; SURFACE ACTIVE AGENTS ; SURFACTANT ; SURFACTANTES ; SURFACTANTS ; SYNTHESIS ; VERTEBRATES ; VITAMIN K ; Vitamin K - metabolism ; VITAMINA K ; VITAMINE K ; VITAMINS</subject><ispartof>Proc. Natl. Acad. Sci. U.S.A.; (United States), 1987-08, Vol.84 (16), p.5952-5956</ispartof><rights>1988 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c538t-29b9be4a17ebf51cfeba2cc347dd21b462b95045d64107ca7323bacece8979d93</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.pnas.org/content/84/16.cover.gif</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/30158$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/30158$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,727,780,784,803,885,27924,27925,53791,53793,58017,58250</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7845136$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3475711$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/5209484$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Rannels, S.R</creatorcontrib><creatorcontrib>Gallaher, K.J</creatorcontrib><creatorcontrib>Wallin, R</creatorcontrib><creatorcontrib>Rannels, D.E</creatorcontrib><creatorcontrib>Pennsylvania State Univ., Hershey (USA)</creatorcontrib><title>Vitamin K-dependent carboxylation of pulmonary surfactant-associated proteins</title><title>Proc. Natl. Acad. Sci. U.S.A.; (United States)</title><addtitle>Proc Natl Acad Sci U S A</addtitle><description>Rat type II pneumocytes expressed vitamin K-dependent carboxylase activity that incorporated 14CO2 into microsomal protein precursors of molecular weights similar to those of surfactant-associated proteins (SAP). Compared to carboxylated precursor proteins present in the liver, these molecules appeared to be unique to the lung. Antibodies raised against purified rat surfactant reacted with SAP resolved by NaDodSO4/PAGE and with surfactant-containing lamellar bodies in type II pneumocyte cytoplasm. NaDodSO4/PAGE of microsomal proteins, after carboxylase-catalyzed incorporation of 14CO2, demonstrated radiolabeled, immunoreactive products identical to SAP. The presence of γ -carboxyglutamic acid in these proteins was confirmed by HPLC analysis of SAP hydrolysates. Furthermore, lung carboxylase activity and SAP matured over similar time courses during fetal lung development. These results show that SAP are carboxylated by type II cells via a vitamin K-dependent pathway analogous to that for hepatic carboxylation of clotting factors. Further analogy to the clotting system suggests that γ -carboxyglutamic acid residues in SAP polypeptides play a role in Ca2+ binding and thus in the known requirements for both the cation and SAP in the physiological function of pulmonary surfactant.</description><subject>550201 - Biochemistry- Tracer Techniques</subject><subject>ANIMAL CELLS</subject><subject>ANIMALS</subject><subject>Antibodies</subject><subject>Applied sciences</subject><subject>AROMATICS</subject><subject>BASIC BIOLOGICAL SCIENCES</subject><subject>BIOSYNTHESIS</subject><subject>BODY</subject><subject>Calcium - metabolism</subject><subject>CARBON 14 COMPOUNDS</subject><subject>CARBON COMPOUNDS</subject><subject>CARBON DIOXIDE</subject><subject>CARBON OXIDES</subject><subject>CARBON-CARBON LYASES</subject><subject>CARBOXY-LYASES</subject><subject>CARBOXYLASE</subject><subject>CARBOXYLATION</subject><subject>CELL CONSTITUENTS</subject><subject>Cells</subject><subject>CHALCOGENIDES</subject><subject>CHEMICAL REACTIONS</subject><subject>Chromatography, High Pressure Liquid</subject><subject>COAGULANTS</subject><subject>DESARROLLO EMBRIONARIO</subject><subject>DEVELOPPEMENT EMBRYONNAIRE</subject><subject>DRUGS</subject><subject>ELECTROPHORESIS</subject><subject>Electrophoresis, Polyacrylamide Gel</subject><subject>EMBRYONIC DEVELOPMENT</subject><subject>ENZYME ACTIVITY</subject><subject>ENZYMES</subject><subject>Epithelial cells</subject><subject>Exact sciences and technology</subject><subject>HEMATOLOGIC AGENTS</subject><subject>HEPARIN ANTAGONISTS</subject><subject>IMMUNE SERUMS</subject><subject>LABELLED COMPOUNDS</subject><subject>LIASAS</subject><subject>Liver</subject><subject>Lung - enzymology</subject><subject>Lung - growth & development</subject><subject>LUNGS</subject><subject>LYASE</subject><subject>LYASES</subject><subject>MAMMALS</subject><subject>MICROSOMES</subject><subject>Microsomes - metabolism</subject><subject>MOLECULAR WEIGHT</subject><subject>ORGANIC COMPOUNDS</subject><subject>ORGANIC OXYGEN COMPOUNDS</subject><subject>ORGANOIDS</subject><subject>ORGANS</subject><subject>Other techniques and industries</subject><subject>OXIDES</subject><subject>OXYGEN COMPOUNDS</subject><subject>Pneumocytes</subject><subject>POUMON</subject><subject>PROTEINAS</subject><subject>PROTEINE</subject><subject>PROTEINS</subject><subject>Proteolipids - metabolism</subject><subject>Pulmonary Surfactant-Associated Proteins</subject><subject>Pulmonary Surfactants - metabolism</subject><subject>PULMONES</subject><subject>QUINONES</subject><subject>RAT</subject><subject>RATA</subject><subject>RATS</subject><subject>RESPIRATORY SYSTEM</subject><subject>RESPIRATORY TRACT CELLS</subject><subject>RODENTS</subject><subject>SURFACE ACTIVE AGENTS</subject><subject>SURFACTANT</subject><subject>SURFACTANTES</subject><subject>SURFACTANTS</subject><subject>SYNTHESIS</subject><subject>VERTEBRATES</subject><subject>VITAMIN K</subject><subject>Vitamin K - metabolism</subject><subject>VITAMINA K</subject><subject>VITAMINE K</subject><subject>VITAMINS</subject><issn>0027-8424</issn><issn>1091-6490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kUtv1DAURiMEKkNhjYQARQjBKlM_Y3vBAlW8RBELKFvrxnFaVxk72A5q_z0eJQx0w8qL79x7j_VV1WOMthgJejJ5SFvJtrjdcsXJnWqDkcJNyxS6W20QIqKRjLD71YOUrhBCikt0VB1RJrjAeFN9-eEy7JyvPze9nazvrc-1gdiF65sRsgu-DkM9zeMueIg3dZrjACaDzw2kFIyDbPt6iiFb59PD6t4AY7KP1ve4On__7vvpx-bs64dPp2_PGsOpzA1RneosAyxsN3BsBtsBMaZI9T3BHWtJpzhivG9Z-aQBQQntwFhjpRKqV_S4erPsneZuZ3tTpCOMeopuVyR1AKdvJ95d6ovwSxMllcRl_sUyH1J2OhmXrbk0wXtrsuYEKSZZgV6tR2L4OduU9c4lY8cRvA1z0kK0hGIqCniygCaGlKIdDiIY6X1Let-SlkzjVu9bKhPP_vU_8GstJX-55pAMjEMEb1w6YEIyjmlbsOcrtt__J7115_V_AT3M45jtdS7kk4W8SjnEv0IIc1nCp0s4QNBwEYvK-TdZVClCUtLfN9LG8A</recordid><startdate>19870801</startdate><enddate>19870801</enddate><creator>Rannels, S.R</creator><creator>Gallaher, K.J</creator><creator>Wallin, R</creator><creator>Rannels, D.E</creator><general>National Academy of Sciences of the United States of America</general><general>National Acad Sciences</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>OTOTI</scope><scope>5PM</scope></search><sort><creationdate>19870801</creationdate><title>Vitamin K-dependent carboxylation of pulmonary surfactant-associated proteins</title><author>Rannels, S.R ; Gallaher, K.J ; Wallin, R ; Rannels, D.E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c538t-29b9be4a17ebf51cfeba2cc347dd21b462b95045d64107ca7323bacece8979d93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>550201 - Biochemistry- Tracer Techniques</topic><topic>ANIMAL CELLS</topic><topic>ANIMALS</topic><topic>Antibodies</topic><topic>Applied sciences</topic><topic>AROMATICS</topic><topic>BASIC BIOLOGICAL SCIENCES</topic><topic>BIOSYNTHESIS</topic><topic>BODY</topic><topic>Calcium - metabolism</topic><topic>CARBON 14 COMPOUNDS</topic><topic>CARBON COMPOUNDS</topic><topic>CARBON DIOXIDE</topic><topic>CARBON OXIDES</topic><topic>CARBON-CARBON LYASES</topic><topic>CARBOXY-LYASES</topic><topic>CARBOXYLASE</topic><topic>CARBOXYLATION</topic><topic>CELL CONSTITUENTS</topic><topic>Cells</topic><topic>CHALCOGENIDES</topic><topic>CHEMICAL REACTIONS</topic><topic>Chromatography, High Pressure Liquid</topic><topic>COAGULANTS</topic><topic>DESARROLLO EMBRIONARIO</topic><topic>DEVELOPPEMENT EMBRYONNAIRE</topic><topic>DRUGS</topic><topic>ELECTROPHORESIS</topic><topic>Electrophoresis, Polyacrylamide Gel</topic><topic>EMBRYONIC DEVELOPMENT</topic><topic>ENZYME ACTIVITY</topic><topic>ENZYMES</topic><topic>Epithelial cells</topic><topic>Exact sciences and technology</topic><topic>HEMATOLOGIC AGENTS</topic><topic>HEPARIN ANTAGONISTS</topic><topic>IMMUNE SERUMS</topic><topic>LABELLED COMPOUNDS</topic><topic>LIASAS</topic><topic>Liver</topic><topic>Lung - enzymology</topic><topic>Lung - growth & development</topic><topic>LUNGS</topic><topic>LYASE</topic><topic>LYASES</topic><topic>MAMMALS</topic><topic>MICROSOMES</topic><topic>Microsomes - metabolism</topic><topic>MOLECULAR WEIGHT</topic><topic>ORGANIC COMPOUNDS</topic><topic>ORGANIC OXYGEN COMPOUNDS</topic><topic>ORGANOIDS</topic><topic>ORGANS</topic><topic>Other techniques and industries</topic><topic>OXIDES</topic><topic>OXYGEN COMPOUNDS</topic><topic>Pneumocytes</topic><topic>POUMON</topic><topic>PROTEINAS</topic><topic>PROTEINE</topic><topic>PROTEINS</topic><topic>Proteolipids - metabolism</topic><topic>Pulmonary Surfactant-Associated Proteins</topic><topic>Pulmonary Surfactants - metabolism</topic><topic>PULMONES</topic><topic>QUINONES</topic><topic>RAT</topic><topic>RATA</topic><topic>RATS</topic><topic>RESPIRATORY SYSTEM</topic><topic>RESPIRATORY TRACT CELLS</topic><topic>RODENTS</topic><topic>SURFACE ACTIVE AGENTS</topic><topic>SURFACTANT</topic><topic>SURFACTANTES</topic><topic>SURFACTANTS</topic><topic>SYNTHESIS</topic><topic>VERTEBRATES</topic><topic>VITAMIN K</topic><topic>Vitamin K - metabolism</topic><topic>VITAMINA K</topic><topic>VITAMINE K</topic><topic>VITAMINS</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rannels, S.R</creatorcontrib><creatorcontrib>Gallaher, K.J</creatorcontrib><creatorcontrib>Wallin, R</creatorcontrib><creatorcontrib>Rannels, D.E</creatorcontrib><creatorcontrib>Pennsylvania State Univ., Hershey (USA)</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>OSTI.GOV</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Proc. Natl. Acad. Sci. U.S.A.; (United States)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rannels, S.R</au><au>Gallaher, K.J</au><au>Wallin, R</au><au>Rannels, D.E</au><aucorp>Pennsylvania State Univ., Hershey (USA)</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Vitamin K-dependent carboxylation of pulmonary surfactant-associated proteins</atitle><jtitle>Proc. Natl. Acad. Sci. U.S.A.; (United States)</jtitle><addtitle>Proc Natl Acad Sci U S A</addtitle><date>1987-08-01</date><risdate>1987</risdate><volume>84</volume><issue>16</issue><spage>5952</spage><epage>5956</epage><pages>5952-5956</pages><issn>0027-8424</issn><eissn>1091-6490</eissn><coden>PNASA6</coden><abstract>Rat type II pneumocytes expressed vitamin K-dependent carboxylase activity that incorporated 14CO2 into microsomal protein precursors of molecular weights similar to those of surfactant-associated proteins (SAP). Compared to carboxylated precursor proteins present in the liver, these molecules appeared to be unique to the lung. Antibodies raised against purified rat surfactant reacted with SAP resolved by NaDodSO4/PAGE and with surfactant-containing lamellar bodies in type II pneumocyte cytoplasm. NaDodSO4/PAGE of microsomal proteins, after carboxylase-catalyzed incorporation of 14CO2, demonstrated radiolabeled, immunoreactive products identical to SAP. The presence of γ -carboxyglutamic acid in these proteins was confirmed by HPLC analysis of SAP hydrolysates. Furthermore, lung carboxylase activity and SAP matured over similar time courses during fetal lung development. These results show that SAP are carboxylated by type II cells via a vitamin K-dependent pathway analogous to that for hepatic carboxylation of clotting factors. Further analogy to the clotting system suggests that γ -carboxyglutamic acid residues in SAP polypeptides play a role in Ca2+ binding and thus in the known requirements for both the cation and SAP in the physiological function of pulmonary surfactant.</abstract><cop>Washington, DC</cop><pub>National Academy of Sciences of the United States of America</pub><pmid>3475711</pmid><doi>10.1073/pnas.84.16.5952</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Proc. Natl. Acad. Sci. U.S.A.; (United States), 1987-08, Vol.84 (16), p.5952-5956 |
| issn | 0027-8424 1091-6490 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_298981 |
| source | MEDLINE; JSTOR Archive Collection A-Z Listing; PubMed Central; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
| subjects | 550201 - Biochemistry- Tracer Techniques ANIMAL CELLS ANIMALS Antibodies Applied sciences AROMATICS BASIC BIOLOGICAL SCIENCES BIOSYNTHESIS BODY Calcium - metabolism CARBON 14 COMPOUNDS CARBON COMPOUNDS CARBON DIOXIDE CARBON OXIDES CARBON-CARBON LYASES CARBOXY-LYASES CARBOXYLASE CARBOXYLATION CELL CONSTITUENTS Cells CHALCOGENIDES CHEMICAL REACTIONS Chromatography, High Pressure Liquid COAGULANTS DESARROLLO EMBRIONARIO DEVELOPPEMENT EMBRYONNAIRE DRUGS ELECTROPHORESIS Electrophoresis, Polyacrylamide Gel EMBRYONIC DEVELOPMENT ENZYME ACTIVITY ENZYMES Epithelial cells Exact sciences and technology HEMATOLOGIC AGENTS HEPARIN ANTAGONISTS IMMUNE SERUMS LABELLED COMPOUNDS LIASAS Liver Lung - enzymology Lung - growth & development LUNGS LYASE LYASES MAMMALS MICROSOMES Microsomes - metabolism MOLECULAR WEIGHT ORGANIC COMPOUNDS ORGANIC OXYGEN COMPOUNDS ORGANOIDS ORGANS Other techniques and industries OXIDES OXYGEN COMPOUNDS Pneumocytes POUMON PROTEINAS PROTEINE PROTEINS Proteolipids - metabolism Pulmonary Surfactant-Associated Proteins Pulmonary Surfactants - metabolism PULMONES QUINONES RAT RATA RATS RESPIRATORY SYSTEM RESPIRATORY TRACT CELLS RODENTS SURFACE ACTIVE AGENTS SURFACTANT SURFACTANTES SURFACTANTS SYNTHESIS VERTEBRATES VITAMIN K Vitamin K - metabolism VITAMINA K VITAMINE K VITAMINS |
| title | Vitamin K-dependent carboxylation of pulmonary surfactant-associated proteins |
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