The relation of preoperative coagulation findings to diagnosis, blood usage, and survival in adult liver transplantation
A group of 70 adults with end-stage liver disease received 87 homologous liver transplants from 7/11/81 and 7/11/83. The recipients fell into the following diagnostic categories: postnecrotic cirrhosis (PNC) in 22, primary biliary cirrhosis (PBC) in 18, cancer or neoplasia (CA) in 11, sclerosing cho...
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| Veröffentlicht in: | Transplantation 1985-05, Vol.39 (5), p.532-536 |
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| creator | BONTEMPO, F. A LEWIS, J. H VAN THIEL, D. H SPERO, J. A RAGNI, M. V BUTLER, P ISRAEL, L STARZL, T. E |
| description | A group of 70 adults with end-stage liver disease received 87 homologous liver transplants from 7/11/81 and 7/11/83. The recipients fell into the following diagnostic categories: postnecrotic cirrhosis (PNC) in 22, primary biliary cirrhosis (PBC) in 18, cancer or neoplasia (CA) in 11, sclerosing cholangitis (SC) in 8 and miscellaneous (MISC) in 11. Survival for six months or longer was 46%: survival by group was PBC = 67%, CA = 55%, PNC = 45%, SC = 25%, and MISC = 18%. Preoperative coagulation profiles were evaluated on 64 of the 70 first transplant patients by assigning a score derived from one point per abnormality in each of 8 tests. Mean coagulation abnormality scores (CAS) were strikingly elevated in the PNC and MISC groups. Mean intraoperative blood product usage was 43 units of RBCs, 40 units of fresh frozen plasma (FFP), 21 units of platelets, and 9 bags of cryoprecipitate. Direct correlations were found between CAS and RBC usage (+0.454, P = less than .001), CAS, and survival of 6 months or longer (-0.281, P = less than .02), and RBC usage and survival (-0.408, P = less than .001). These findings indicate that the degree of coagulation abnormality and the type of liver disease may be predictive of intraoperative blood usage and survival in liver transplantation in adults. |
| doi_str_mv | 10.1097/00007890-198505000-00015 |
| format | Article |
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Mean coagulation abnormality scores (CAS) were strikingly elevated in the PNC and MISC groups. Mean intraoperative blood product usage was 43 units of RBCs, 40 units of fresh frozen plasma (FFP), 21 units of platelets, and 9 bags of cryoprecipitate. Direct correlations were found between CAS and RBC usage (+0.454, P = less than .001), CAS, and survival of 6 months or longer (-0.281, P = less than .02), and RBC usage and survival (-0.408, P = less than .001). These findings indicate that the degree of coagulation abnormality and the type of liver disease may be predictive of intraoperative blood usage and survival in liver transplantation in adults.</description><identifier>ISSN: 0041-1337</identifier><identifier>EISSN: 1534-6080</identifier><identifier>DOI: 10.1097/00007890-198505000-00015</identifier><identifier>PMID: 3887694</identifier><identifier>CODEN: TRPLAU</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott</publisher><subject>Adolescent ; Adult ; Biological and medical sciences ; Blood Coagulation Disorders - diagnosis ; Blood Coagulation Disorders - etiology ; Female ; Humans ; Liver Diseases - blood ; Liver Diseases - complications ; Liver Diseases - diagnosis ; Liver Diseases - surgery ; Liver Transplantation ; Liver, biliary tract, pancreas, portal circulation, spleen ; Male ; Medical sciences ; Middle Aged ; Prognosis ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Surgery of the digestive system</subject><ispartof>Transplantation, 1985-05, Vol.39 (5), p.532-536</ispartof><rights>1985 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c444t-7cfd98f0cc5f96ec266fceca1622d80a7df84e3224bb63ea27348a7ed3cbff593</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9185143$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3887694$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>BONTEMPO, F. A</creatorcontrib><creatorcontrib>LEWIS, J. H</creatorcontrib><creatorcontrib>VAN THIEL, D. H</creatorcontrib><creatorcontrib>SPERO, J. A</creatorcontrib><creatorcontrib>RAGNI, M. V</creatorcontrib><creatorcontrib>BUTLER, P</creatorcontrib><creatorcontrib>ISRAEL, L</creatorcontrib><creatorcontrib>STARZL, T. E</creatorcontrib><title>The relation of preoperative coagulation findings to diagnosis, blood usage, and survival in adult liver transplantation</title><title>Transplantation</title><addtitle>Transplantation</addtitle><description>A group of 70 adults with end-stage liver disease received 87 homologous liver transplants from 7/11/81 and 7/11/83. The recipients fell into the following diagnostic categories: postnecrotic cirrhosis (PNC) in 22, primary biliary cirrhosis (PBC) in 18, cancer or neoplasia (CA) in 11, sclerosing cholangitis (SC) in 8 and miscellaneous (MISC) in 11. Survival for six months or longer was 46%: survival by group was PBC = 67%, CA = 55%, PNC = 45%, SC = 25%, and MISC = 18%. Preoperative coagulation profiles were evaluated on 64 of the 70 first transplant patients by assigning a score derived from one point per abnormality in each of 8 tests. Mean coagulation abnormality scores (CAS) were strikingly elevated in the PNC and MISC groups. Mean intraoperative blood product usage was 43 units of RBCs, 40 units of fresh frozen plasma (FFP), 21 units of platelets, and 9 bags of cryoprecipitate. Direct correlations were found between CAS and RBC usage (+0.454, P = less than .001), CAS, and survival of 6 months or longer (-0.281, P = less than .02), and RBC usage and survival (-0.408, P = less than .001). These findings indicate that the degree of coagulation abnormality and the type of liver disease may be predictive of intraoperative blood usage and survival in liver transplantation in adults.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Blood Coagulation Disorders - diagnosis</subject><subject>Blood Coagulation Disorders - etiology</subject><subject>Female</subject><subject>Humans</subject><subject>Liver Diseases - blood</subject><subject>Liver Diseases - complications</subject><subject>Liver Diseases - diagnosis</subject><subject>Liver Diseases - surgery</subject><subject>Liver Transplantation</subject><subject>Liver, biliary tract, pancreas, portal circulation, spleen</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Prognosis</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. 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V</creator><creator>BUTLER, P</creator><creator>ISRAEL, L</creator><creator>STARZL, T. E</creator><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19850501</creationdate><title>The relation of preoperative coagulation findings to diagnosis, blood usage, and survival in adult liver transplantation</title><author>BONTEMPO, F. A ; LEWIS, J. H ; VAN THIEL, D. H ; SPERO, J. A ; RAGNI, M. V ; BUTLER, P ; ISRAEL, L ; STARZL, T. 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Graft diseases</topic><topic>Surgery of the digestive system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>BONTEMPO, F. A</creatorcontrib><creatorcontrib>LEWIS, J. H</creatorcontrib><creatorcontrib>VAN THIEL, D. H</creatorcontrib><creatorcontrib>SPERO, J. A</creatorcontrib><creatorcontrib>RAGNI, M. V</creatorcontrib><creatorcontrib>BUTLER, P</creatorcontrib><creatorcontrib>ISRAEL, L</creatorcontrib><creatorcontrib>STARZL, T. 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E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The relation of preoperative coagulation findings to diagnosis, blood usage, and survival in adult liver transplantation</atitle><jtitle>Transplantation</jtitle><addtitle>Transplantation</addtitle><date>1985-05-01</date><risdate>1985</risdate><volume>39</volume><issue>5</issue><spage>532</spage><epage>536</epage><pages>532-536</pages><issn>0041-1337</issn><eissn>1534-6080</eissn><coden>TRPLAU</coden><abstract>A group of 70 adults with end-stage liver disease received 87 homologous liver transplants from 7/11/81 and 7/11/83. The recipients fell into the following diagnostic categories: postnecrotic cirrhosis (PNC) in 22, primary biliary cirrhosis (PBC) in 18, cancer or neoplasia (CA) in 11, sclerosing cholangitis (SC) in 8 and miscellaneous (MISC) in 11. Survival for six months or longer was 46%: survival by group was PBC = 67%, CA = 55%, PNC = 45%, SC = 25%, and MISC = 18%. Preoperative coagulation profiles were evaluated on 64 of the 70 first transplant patients by assigning a score derived from one point per abnormality in each of 8 tests. Mean coagulation abnormality scores (CAS) were strikingly elevated in the PNC and MISC groups. Mean intraoperative blood product usage was 43 units of RBCs, 40 units of fresh frozen plasma (FFP), 21 units of platelets, and 9 bags of cryoprecipitate. Direct correlations were found between CAS and RBC usage (+0.454, P = less than .001), CAS, and survival of 6 months or longer (-0.281, P = less than .02), and RBC usage and survival (-0.408, P = less than .001). 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| ispartof | Transplantation, 1985-05, Vol.39 (5), p.532-536 |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Adolescent Adult Biological and medical sciences Blood Coagulation Disorders - diagnosis Blood Coagulation Disorders - etiology Female Humans Liver Diseases - blood Liver Diseases - complications Liver Diseases - diagnosis Liver Diseases - surgery Liver Transplantation Liver, biliary tract, pancreas, portal circulation, spleen Male Medical sciences Middle Aged Prognosis Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the digestive system |
| title | The relation of preoperative coagulation findings to diagnosis, blood usage, and survival in adult liver transplantation |
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