The Aging Stress Response
Aging is the outcome of a balance between damage and repair. The rate of aging and the appearance of age-related pathology are modulated by stress response and repair pathways that gradually decline, including the proteostasis and DNA damage repair networks and mitochondrial respiratory metabolism....
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| Veröffentlicht in: | Molecular cell 2010-10, Vol.40 (2), p.333-344 |
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| container_title | Molecular cell |
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| creator | Haigis, Marcia C. Yankner, Bruce A. |
| description | Aging is the outcome of a balance between damage and repair. The rate of aging and the appearance of age-related pathology are modulated by stress response and repair pathways that gradually decline, including the proteostasis and DNA damage repair networks and mitochondrial respiratory metabolism. Highly conserved insulin/IGF-1, TOR, and sirtuin signaling pathways in turn control these critical cellular responses. The coordinated action of these signaling pathways maintains cellular and organismal homeostasis in the face of external perturbations, such as changes in nutrient availability, temperature, and oxygen level, as well as internal perturbations, such as protein misfolding and DNA damage. Studies in model organisms suggest that changes in signaling can augment these critical stress response systems, increasing life span and reducing age-related pathology. The systems biology of stress response signaling thus provides a new approach to the understanding and potential treatment of age-related diseases. |
| doi_str_mv | 10.1016/j.molcel.2010.10.002 |
| format | Article |
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The rate of aging and the appearance of age-related pathology are modulated by stress response and repair pathways that gradually decline, including the proteostasis and DNA damage repair networks and mitochondrial respiratory metabolism. Highly conserved insulin/IGF-1, TOR, and sirtuin signaling pathways in turn control these critical cellular responses. The coordinated action of these signaling pathways maintains cellular and organismal homeostasis in the face of external perturbations, such as changes in nutrient availability, temperature, and oxygen level, as well as internal perturbations, such as protein misfolding and DNA damage. Studies in model organisms suggest that changes in signaling can augment these critical stress response systems, increasing life span and reducing age-related pathology. The systems biology of stress response signaling thus provides a new approach to the understanding and potential treatment of age-related diseases.</description><subject>Aging - physiology</subject><subject>Animals</subject><subject>Cellular Senescence - physiology</subject><subject>Humans</subject><subject>Models, Biological</subject><subject>Neoplasms - physiopathology</subject><subject>Neurodegenerative Diseases - physiopathology</subject><subject>Oxidative Stress - physiology</subject><subject>Signal Transduction</subject><subject>Stress, Physiological - physiology</subject><issn>1097-2765</issn><issn>1097-4164</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE9LAzEQxYMotlY_gCDSm6ddk2ySzV4EKf6DgqD1HLLZaZuy3dRkW_Dbm7W16sXTDDNv3kt-CF0QnBJMxPUiXbraQJ1S_DVKMaYHqE9wkSeMCHa462kueA-dhLDAmDAui2PUo7gQnFHRR-eTOQxvZ7aZDV9bDyEMXyCsXBPgFB1NdR3gbFcH6O3-bjJ6TMbPD0-j23FimKBtAkRKkLgAwCXDnOa6AFHgPGZXkpSEViwTcqq7reGUV5RqjlnGS8EylpXZAN1sfVfrcgmVgab1ulYrb5fafyinrfq7aexczdxG0ULmgshocLUz8O59DaFVSxsimFo34NZB5TwKpaQkKtlWabwLwcN0n0Kw6qCqhdpCVR3UbhqhxrPL3y_cH31T_PkCRE4bC14FY6ExUFkPplWVs_8nfAJQDYgb</recordid><startdate>20101022</startdate><enddate>20101022</enddate><creator>Haigis, Marcia C.</creator><creator>Yankner, Bruce A.</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20101022</creationdate><title>The Aging Stress Response</title><author>Haigis, Marcia C. ; Yankner, Bruce A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c462t-e188e809ee0b40527a9e6907109d81b12d4368fa0b40c525d22a50435b64343b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Aging - physiology</topic><topic>Animals</topic><topic>Cellular Senescence - physiology</topic><topic>Humans</topic><topic>Models, Biological</topic><topic>Neoplasms - physiopathology</topic><topic>Neurodegenerative Diseases - physiopathology</topic><topic>Oxidative Stress - physiology</topic><topic>Signal Transduction</topic><topic>Stress, Physiological - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Haigis, Marcia C.</creatorcontrib><creatorcontrib>Yankner, Bruce A.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Molecular cell</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Haigis, Marcia C.</au><au>Yankner, Bruce A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Aging Stress Response</atitle><jtitle>Molecular cell</jtitle><addtitle>Mol Cell</addtitle><date>2010-10-22</date><risdate>2010</risdate><volume>40</volume><issue>2</issue><spage>333</spage><epage>344</epage><pages>333-344</pages><issn>1097-2765</issn><eissn>1097-4164</eissn><abstract>Aging is the outcome of a balance between damage and repair. 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| source | MEDLINE; Cell Press Free Archives; Access via ScienceDirect (Elsevier); EZB-FREE-00999 freely available EZB journals; Free Full-Text Journals in Chemistry |
| subjects | Aging - physiology Animals Cellular Senescence - physiology Humans Models, Biological Neoplasms - physiopathology Neurodegenerative Diseases - physiopathology Oxidative Stress - physiology Signal Transduction Stress, Physiological - physiology |
| title | The Aging Stress Response |
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