High-Efficiency Transduction of Fibroblasts and Mesenchymal Stem Cells by Tyrosine-Mutant AAV2 Vectors for Their Potential Use in Cellular Therapy

Adeno-associated virus 2 (AAV2) vectors transduce fibroblasts and mesenchymal stem cells (MSCs) inefficiently, which limits their potential widespread applicability in combinatorial gene and cell therapy. We have reported that AAV2 vectors fail to traffic efficiently to the nucleus in murine fibrobl...

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Veröffentlicht in:	Human gene therapy 2010-11, Vol.21 (11), p.1527-1543
Hauptverfasser:	MENGXIN LI, JAYANDHARAN, Giridhara R, BAOZHENG LI, CHEN LING, WENQIN MA, SRIVASTAVA, Arun, LI ZHONG
Format:	Artikel
Sprache:	eng
Schlagworte:	Adeno-associated virus Adenoviruses Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Applied cell therapy and gene therapy Biological and medical sciences Biotechnology Cellular signal transduction Dependovirus - genetics Dependovirus - metabolism Fibroblasts Fibroblasts - metabolism Fundamental and applied biological sciences. Psychology Gene therapy Genetic aspects Genetic Therapy - methods Genetic Vectors Health aspects Health. Pharmaceutical industry Humans Industrial applications and implications. Economical aspects Medical sciences Mesenchymal Stromal Cells - metabolism Mice Mice, Inbred C57BL Mice, Knockout Mutagenesis, Site-Directed Mutation Physiological aspects Stem cells Tacrolimus Binding Proteins - metabolism Transduction, Genetic Transfusions. Complications. Transfusion reactions. Cell and gene therapy Transgenes Tyrosine - genetics
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