MTHFR 677 C>T and 1298 A>C polymorphisms and the age of onset of colorectal cancer in hereditary nonpolyposis colorectal cancer

Hereditary non-polyposis colorectal cancer (HNPCC) or Lynch syndrome is characterized by inactivating germline mutations in DNA mismatch repair genes resulting in an increased risk of developing an epithelial malignancy. There is considerable variability in disease expression observed in this syndro...

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Veröffentlicht in:	European journal of human genetics : EJHG 2009-05, Vol.17 (5), p.629-635
Hauptverfasser:	Reeves, Stuart G, Meldrum, Cliff, Groombridge, Claire, Spigelman, Allan D, Suchy, Janina, Kurzawski, Grzegorz, Lubinski, Jan, McElduff, Patrick, Scott, Rodney J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Age Age of Onset Alleles Bioinformatics Biological and medical sciences Biomarkers Biomedical and Life Sciences Biomedicine Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - epidemiology Colorectal Neoplasms - genetics Colorectal Neoplasms - pathology Colorectal Neoplasms, Hereditary Nonpolyposis - genetics Colorectal Neoplasms, Hereditary Nonpolyposis - pathology Cytogenetics Deoxyribonucleic acid Diagnosis Dihydrofolate reductase DNA DNA methylation DNA repair Environmental factors Enzymes Female Fundamental and applied biological sciences. Psychology Gastroenterology. Liver. Pancreas. Abdomen Gene Expression Gene Frequency General aspects. Genetic counseling Genes Genetics Genetics of eukaryotes. Biological and molecular evolution Genotype Genotyping Health risk assessment Heterozygotes Homocysteine Human Genetics Humans Kaplan-Meier Estimate Male Malignancy Medical genetics Medical research Medical sciences Metabolism Methylenetetrahydrofolate reductase Methylenetetrahydrofolate Reductase (NADPH2) - genetics Mismatch repair Molecular and cellular biology Mutation Pathology Polymorphism Polymorphism, Single Nucleotide Polyposis Research centers Single-nucleotide polymorphism Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Survival Survival analysis Tetrahydrofolic acid Tumors Vitamin B
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