Cloning and Functional Expression of a Human Pancreatic Islet Glucose-Transporter cDNA

Previous studies have suggested that pancreatic islet glucose transport is mediated by a high-Km, low-affinity facilitated transporter similar to that expressed in liver. To determine the relationship between islet and liver glucose transporters, liver-type glucose-transporter cDNA clones were isola...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1989-11, Vol.86 (22), p.8688-8692
Hauptverfasser:	Permutt, M. Alan, Koranyi, Laszlo, Keller, Konrad, Lacy, Paul E., Scharp, David W., Mueckler, Mike
Format:	Artikel
Sprache:	eng
Schlagworte:	ALDEHYDES ANIMALS BASIC BIOLOGICAL SCIENCES BETA DECAY RADIOISOTOPES BETA-MINUS DECAY RADIOISOTOPES Biochemistry Biological and medical sciences Blotting, Northern BODY CARBOHYDRATES CDNA libraries Cell Line CLONING Cloning, Molecular Complementary DNA DAYS LIVING RADIOISOTOPES Diabetes mellitus DIGESTIVE SYSTEM DNA DNA - genetics DNA HYBRIDIZATION DNA-CLONING ELECTROPHORESIS ENDOCRINE GLANDS Facilitative glucose transport proteins Female Fundamental and applied biological sciences. Psychology Gene Expression Gene Library GENE REGULATION Genes Genes. Genome GLANDS GLUCOSE HEXOSES Humans HYBRIDIZATION HYDROGEN COMPOUNDS Islets of Langerhans Islets of Langerhans - metabolism ISOTOPES LIGHT NUCLEI LIVER MAMMALS MAN MEMBRANE PROTEINS MEMBRANE TRANSPORT MESSENGER-RNA Molecular and cellular biology Molecular genetics Monosaccharide Transport Proteins - genetics MONOSACCHARIDES NUCLEI NUCLEIC ACIDS ODD-ODD NUCLEI Oocytes Oocytes - metabolism ORGANIC COMPOUNDS ORGANS PANCREAS PHOSPHORUS 32 PHOSPHORUS ISOTOPES PRIMATES PROTEINS RADIOISOTOPES RECOMBINANT DNA Restriction Mapping RNA RNA - genetics RNA - isolation & purification SACCHARIDES TRANSCRIPTION TRITIUM COMPOUNDS VERTEBRATES 550201 > Biochemistry-- Tracer Techniques Xenopus
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