Compensatory mutations restore fitness during the evolution of dihydrofolate reductase
Whether a trade-off exists between robustness and evolvability is an important issue for protein evolution. Although traditional viewpoints have assumed that existing functions must be compromised by the evolution of novel activities, recent research has suggested that existing phenotypes can be rob...
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Veröffentlicht in: | Molecular biology and evolution 2010-12, Vol.27 (12), p.2682-2690 |
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