Aziridine-2,3-Dicarboxylate-Based Cysteine Cathepsin Inhibitors Induce Cell Death in Leishmania major Associated with Accumulation of Debris in Autophagy-Related Lysosome-Like Vacuoles

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Veröffentlicht in:	Antimicrobial Agents and Chemotherapy 2010-12, Vol.54 (12), p.5028-5041
Hauptverfasser:	SCHURIGT, Uta, SCHAD, Caroline, GLOWA, Christin, BAUM, Ulrike, THOMALE, Katja, SCHNITZER, Johannes K, SCHULTHEIS, Martina, SCHASCHKE, Norbert, SCHIRMEISTER, Tanja, MOLL, Heidrun
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibiotics. Antiinfectious agents. Antiparasitic agents Autophagy Aziridines Aziridines - pharmacology Biological and medical sciences Cysteine Proteinase Inhibitors Cysteine Proteinase Inhibitors - pharmacology Leishmania major Leishmania major - drug effects Leishmania major - ultrastructure Lysosomes Lysosomes - metabolism Mechanisms of Action: Physiological Effects Medical sciences Mice Mice, Inbred BALB C Microscopy, Electron, Transmission Pharmacology. Drug treatments Vacuoles Vacuoles - drug effects Vacuoles - ultrastructure
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