Linoleic acid supplementation results in increased arachidonic acid and eicosanoid production in CF airway cells and in cftr-/- transgenic mice

Cystic fibrosis (CF) patients display a fatty acid imbalance characterized by low linoleic acid levels and variable changes in arachidonic acid. This led to the recommendation that CF patients consume a high-fat diet containing >6% linoleic acid. We hypothesized that increased conversion of linol...

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Veröffentlicht in:	American journal of physiology. Lung cellular and molecular physiology 2010-11, Vol.299 (5), p.L599-L606
Hauptverfasser:	Zaman, Munir M, Martin, Camilia R, Andersson, Charlotte, Bhutta, Abdul Q, Cluette-Brown, Joanne E, Laposata, Michael, Freedman, Steven D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arachidonic Acid - biosynthesis Biomarkers - metabolism Bronchoalveolar Lavage Fluid - chemistry Bronchoalveolar Lavage Fluid - cytology Cell Line Cystic Fibrosis - diet therapy Cystic Fibrosis - immunology Cystic Fibrosis - microbiology Cystic Fibrosis - physiopathology Dietary Supplements Disease Models, Animal Eicosanoids - biosynthesis Eicosanoids - secretion Fatty Acids - metabolism Humans Inflammation - physiopathology Interleukin-8 - immunology Interleukin-8 - secretion Linoleic Acid - administration & dosage Linoleic Acid - therapeutic use MAP Kinase Signaling System - physiology Mice Mice, Inbred CFTR Mice, Knockout Mice, Transgenic Pseudomonas Pseudomonas aeruginosa - immunology Respiratory Mucosa - cytology
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